diff --git a/Realm/Realm/Native/NativeCommon.cs b/Realm/Realm/Native/NativeCommon.cs
index f389d9e1b2..3b482393c8 100644
--- a/Realm/Realm/Native/NativeCommon.cs
+++ b/Realm/Realm/Native/NativeCommon.cs
@@ -51,6 +51,14 @@ internal static void Initialize()
                         if (libraryName == InteropConfig.DLL_NAME)
                         {
                             libraryName = "@rpath/realm-wrappers.framework/realm-wrappers";
+
+                            var runtimeVersion = Environment.Version;
+                            if (runtimeVersion.Major >= 10)
+                            {
+                                // .NET 10 breaking change: Application directory is no longer used when searching for DLLs
+                                // We need to explicitly add it to the search path
+                                searchPath |= DllImportSearchPath.ApplicationDirectory;
+                            }
                         }
 
                         return NativeLibrary.Load(libraryName, assembly, searchPath);