diff --git a/CHANGELOG.md b/CHANGELOG.md
index 4733988e8be..83c96a7fc40 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -22,6 +22,7 @@
 - PR #5072 Adding cython binding to `get_element`
 - PR #4881 Support row_number in rolling_window
 - PR #5068 Add Java bindings for arctan2
+- PR #5132 Support out-of-band buffers in Python pickling
 
 ## Improvements
 
diff --git a/python/cudf/cudf/core/buffer.py b/python/cudf/cudf/core/buffer.py
index dc7a502cb8b..5b06148430e 100644
--- a/python/cudf/cudf/core/buffer.py
+++ b/python/cudf/cudf/core/buffer.py
@@ -58,8 +58,11 @@ def __init__(self, data=None, size=None, owner=None):
                 raise TypeError("data must be Buffer, array-like or integer")
             self._init_from_array_like(np.asarray(data), owner)
 
-    def __reduce__(self):
-        return self.__class__, (self.to_host_array(),)
+    def __reduce_ex__(self, protocol):
+        data = self.to_host_array()
+        if protocol >= 5:
+            data = pickle.PickleBuffer(data)
+        return self.__class__, (data,)
 
     def __len__(self):
         return self.size