diff --git a/CHANGELOG.md b/CHANGELOG.md
index 8433c6ea5..69e0b21ea 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -14,6 +14,7 @@ Fixes:
 
 Features:
 
+- [#1757](https://github.com/rails-api/active_model_serializers/pull/1757) Make serializer lookup chain configurable. (@NullVoxPopuli)
 - [#1968](https://github.com/rails-api/active_model_serializers/pull/1968) (@NullVoxPopuli)
   - Add controller namespace to default controller lookup
   - Provide a `namespace` render option
diff --git a/docs/general/configuration_options.md b/docs/general/configuration_options.md
index b83399a20..83f8890d7 100644
--- a/docs/general/configuration_options.md
+++ b/docs/general/configuration_options.md
@@ -60,6 +60,56 @@ application, setting `config.key_transform` to `:unaltered` will provide a perfo
 What relationships to serialize by default.  Default: `'*'`, which includes one level of related
 objects. See [includes](adapters.md#included) for more info.
 
+
+##### serializer_lookup_chain
+
+Configures how serializers are searched for. By default, the lookup chain is
+
+```ruby
+ActiveModelSerializers::LookupChain::DEFAULT
+```
+
+which is shorthand for
+
+```ruby
+[
+  ActiveModelSerializers::LookupChain::BY_PARENT_SERIALIZER,
+  ActiveModelSerializers::LookupChain::BY_NAMESPACE,
+  ActiveModelSerializers::LookupChain::BY_RESOURCE_NAMESPACE,
+  ActiveModelSerializers::LookupChain::BY_RESOURCE
+]
+```
+
+Each of the array entries represent a proc. A serializer lookup proc will be yielded 3 arguments. `resource_class`, `serializer_class`, and `namespace`.
+
+Note that:
+ - `resource_class` is the class of the resource being rendered
+ - by default `serializer_class` is `ActiveModel::Serializer`
+   - for association lookup it's the "parent" serializer
+ - `namespace` correspond to either the controller namespace or the [optionally] specified [namespace render option](./rendering.md#namespace)
+
+An example config could be:
+
+```ruby
+ActiveModelSerializers.config.serializer_lookup_chain = [
+  lambda do |resource_class, serializer_class, namespace|
+    "API::#{namespace}::#{resource_class}"
+  end
+]
+```
+
+If you simply want to add to the existing lookup_chain. Use `unshift`.
+
+```ruby
+ActiveModelSerializers.config.serializer_lookup_chain.unshift(
+  lambda do |resource_class, serializer_class, namespace|
+    # ...
+  end
+)
+```
+
+See [lookup_chain.rb](https://github.com/rails-api/active_model_serializers/blob/master/lib/active_model_serializers/lookup_chain.rb) for further explanations and examples.
+
 ## JSON API
 
 ##### jsonapi_resource_type
diff --git a/lib/active_model/serializer.rb b/lib/active_model/serializer.rb
index 81beffd7c..0d94bfb50 100644
--- a/lib/active_model/serializer.rb
+++ b/lib/active_model/serializer.rb
@@ -60,17 +60,10 @@ class << self
 
     # @api private
     def self.serializer_lookup_chain_for(klass, namespace = nil)
-      chain = []
-
-      resource_class_name = klass.name.demodulize
-      resource_namespace = klass.name.deconstantize
-      serializer_class_name = "#{resource_class_name}Serializer"
-
-      chain.push("#{namespace}::#{serializer_class_name}") if namespace
-      chain.push("#{name}::#{serializer_class_name}") if self != ActiveModel::Serializer
-      chain.push("#{resource_namespace}::#{serializer_class_name}")
-
-      chain
+      lookups = ActiveModelSerializers.config.serializer_lookup_chain
+      Array[*lookups].flat_map do |lookup|
+        lookup.call(klass, self, namespace)
+      end.compact
     end
 
     # Used to cache serializer name => serializer class
diff --git a/lib/active_model/serializer/concerns/configuration.rb b/lib/active_model/serializer/concerns/configuration.rb
index c5e73e5b9..d6d3c6106 100644
--- a/lib/active_model/serializer/concerns/configuration.rb
+++ b/lib/active_model/serializer/concerns/configuration.rb
@@ -32,6 +32,26 @@ def config.array_serializer
         config.jsonapi_include_toplevel_object = false
         config.include_data_default = true
 
+        # For configuring how serializers are found.
+        # This should be an array of procs.
+        #
+        # The priority of the output is that the first item
+        # in the evaluated result array will take precedence
+        # over other possible serializer paths.
+        #
+        # i.e.: First match wins.
+        #
+        # @example output
+        # => [
+        #   "CustomNamespace::ResourceSerializer",
+        #   "ParentSerializer::ResourceSerializer",
+        #   "ResourceNamespace::ResourceSerializer" ,
+        #   "ResourceSerializer"]
+        #
+        # If CustomNamespace::ResourceSerializer exists, it will be used
+        # for serialization
+        config.serializer_lookup_chain = ActiveModelSerializers::LookupChain::DEFAULT.dup
+
         config.schema_path = 'test/support/schemas'
       end
     end
diff --git a/lib/active_model_serializers.rb b/lib/active_model_serializers.rb
index 76a32c497..b55dae35a 100644
--- a/lib/active_model_serializers.rb
+++ b/lib/active_model_serializers.rb
@@ -14,6 +14,7 @@ module ActiveModelSerializers
   autoload :Adapter
   autoload :JsonPointer
   autoload :Deprecate
+  autoload :LookupChain
 
   class << self; attr_accessor :logger; end
   self.logger = ActiveSupport::TaggedLogging.new(ActiveSupport::Logger.new(STDOUT))
diff --git a/lib/active_model_serializers/lookup_chain.rb b/lib/active_model_serializers/lookup_chain.rb
new file mode 100644
index 000000000..25db8e138
--- /dev/null
+++ b/lib/active_model_serializers/lookup_chain.rb
@@ -0,0 +1,80 @@
+module ActiveModelSerializers
+  module LookupChain
+    # Standard appending of Serializer to the resource name.
+    #
+    # Example:
+    #   Author => AuthorSerializer
+    BY_RESOURCE = lambda do |resource_class, _serializer_class, _namespace|
+      serializer_from(resource_class)
+    end
+
+    # Uses the namespace of the resource to find the serializer
+    #
+    # Example:
+    #  British::Author => British::AuthorSerializer
+    BY_RESOURCE_NAMESPACE = lambda do |resource_class, _serializer_class, _namespace|
+      resource_namespace = namespace_for(resource_class)
+      serializer_name = serializer_from(resource_class)
+
+      "#{resource_namespace}::#{serializer_name}"
+    end
+
+    # Uses the controller namespace of the resource to find the serializer
+    #
+    # Example:
+    #  Api::V3::AuthorsController => Api::V3::AuthorSerializer
+    BY_NAMESPACE = lambda do |resource_class, _serializer_class, namespace|
+      resource_name = resource_class_name(resource_class)
+      namespace ? "#{namespace}::#{resource_name}Serializer" : nil
+    end
+
+    # Allows for serializers to be defined in parent serializers
+    # - useful if a relationship only needs a different set of attributes
+    #   than if it were rendered independently.
+    #
+    # Example:
+    #   class BlogSerializer < ActiveModel::Serializer
+    #     class AuthorSerialier < ActiveModel::Serializer
+    #     ...
+    #     end
+    #
+    #     belongs_to :author
+    #     ...
+    #   end
+    #
+    #  The belongs_to relationship would be rendered with
+    #    BlogSerializer::AuthorSerialier
+    BY_PARENT_SERIALIZER = lambda do |resource_class, serializer_class, _namespace|
+      return if serializer_class == ActiveModel::Serializer
+
+      serializer_name = serializer_from(resource_class)
+      "#{serializer_class}::#{serializer_name}"
+    end
+
+    DEFAULT = [
+      BY_PARENT_SERIALIZER,
+      BY_NAMESPACE,
+      BY_RESOURCE_NAMESPACE,
+      BY_RESOURCE
+    ].freeze
+
+    module_function
+
+    def namespace_for(klass)
+      klass.name.deconstantize
+    end
+
+    def resource_class_name(klass)
+      klass.name.demodulize
+    end
+
+    def serializer_from_resource_name(name)
+      "#{name}Serializer"
+    end
+
+    def serializer_from(klass)
+      name = resource_class_name(klass)
+      serializer_from_resource_name(name)
+    end
+  end
+end
diff --git a/test/action_controller/lookup_proc_test.rb b/test/action_controller/lookup_proc_test.rb
new file mode 100644
index 000000000..4d2ad0b10
--- /dev/null
+++ b/test/action_controller/lookup_proc_test.rb
@@ -0,0 +1,49 @@
+require 'test_helper'
+
+module ActionController
+  module Serialization
+    class LookupProcTest < ActionController::TestCase
+      module Api
+        module V3
+          class PostCustomSerializer < ActiveModel::Serializer
+            attributes :title, :body
+
+            belongs_to :author
+          end
+
+          class AuthorCustomSerializer < ActiveModel::Serializer
+            attributes :name
+          end
+
+          class LookupProcTestController < ActionController::Base
+            def implicit_namespaced_serializer
+              author = Author.new(name: 'Bob')
+              post = Post.new(title: 'New Post', body: 'Body', author: author)
+
+              render json: post
+            end
+          end
+        end
+      end
+
+      tests Api::V3::LookupProcTestController
+
+      test 'implicitly uses namespaced serializer' do
+        controller_namespace = lambda do |resource_class, _parent_serializer_class, namespace|
+          "#{namespace}::#{resource_class}CustomSerializer" if namespace
+        end
+
+        with_prepended_lookup(controller_namespace) do
+          get :implicit_namespaced_serializer
+
+          assert_serializer Api::V3::PostCustomSerializer
+
+          expected = { 'title' => 'New Post', 'body' => 'Body', 'author' => { 'name' => 'Bob' } }
+          actual = JSON.parse(@response.body)
+
+          assert_equal expected, actual
+        end
+      end
+    end
+  end
+end
diff --git a/test/action_controller/namespace_lookup_test.rb b/test/action_controller/namespace_lookup_test.rb
index ed5bb7eed..3203fd0b1 100644
--- a/test/action_controller/namespace_lookup_test.rb
+++ b/test/action_controller/namespace_lookup_test.rb
@@ -15,6 +15,16 @@ class BookSerializer < ActiveModel::Serializer
           end
         end
 
+        module VHeader
+          class BookSerializer < ActiveModel::Serializer
+            attributes :title, :body
+
+            def body
+              'header'
+            end
+          end
+        end
+
         module V3
           class BookSerializer < ActiveModel::Serializer
             attributes :title, :body
@@ -92,6 +102,14 @@ def namespace_set_in_before_filter
               book = Book.new(title: 'New Post', body: 'Body')
               render json: book
             end
+
+            def namespace_set_by_request_headers
+              book = Book.new(title: 'New Post', body: 'Body')
+              version_from_header = request.headers['X-API_VERSION']
+              namespace = "ActionController::Serialization::NamespaceLookupTest::#{version_from_header}"
+
+              render json: book, namespace: namespace
+            end
           end
         end
       end
@@ -102,6 +120,13 @@ def namespace_set_in_before_filter
         @test_namespace = self.class.parent
       end
 
+      test 'uses request headers to determine the namespace' do
+        request.env['X-API_VERSION'] = 'Api::VHeader'
+        get :namespace_set_by_request_headers
+
+        assert_serializer Api::VHeader::BookSerializer
+      end
+
       test 'implicitly uses namespaced serializer' do
         get :implicit_namespaced_serializer
 
diff --git a/test/benchmark/bm_lookup_chain.rb b/test/benchmark/bm_lookup_chain.rb
new file mode 100644
index 000000000..3b32727f5
--- /dev/null
+++ b/test/benchmark/bm_lookup_chain.rb
@@ -0,0 +1,83 @@
+require_relative './benchmarking_support'
+require_relative './app'
+
+time = 10
+disable_gc = true
+ActiveModelSerializers.config.key_transform = :unaltered
+
+module AmsBench
+  module Api
+    module V1
+      class PrimaryResourceSerializer < ActiveModel::Serializer
+        attributes :title, :body
+
+        has_many :has_many_relationships
+      end
+
+      class HasManyRelationshipSerializer < ActiveModel::Serializer
+        attribute :body
+      end
+    end
+  end
+  class PrimaryResourceSerializer < ActiveModel::Serializer
+    attributes :title, :body
+
+    has_many :has_many_relationships
+
+    class HasManyRelationshipSerializer < ActiveModel::Serializer
+      attribute :body
+    end
+  end
+end
+
+resource = PrimaryResource.new(
+  id: 1,
+  title: 'title',
+  body: 'body',
+  has_many_relationships: [
+    HasManyRelationship.new(id: 1, body: 'body1'),
+    HasManyRelationship.new(id: 2, body: 'body1')
+  ]
+)
+
+serialization = lambda do
+  ActiveModelSerializers::SerializableResource.new(resource, serializer: AmsBench::PrimaryResourceSerializer).as_json
+  ActiveModelSerializers::SerializableResource.new(resource, namespace: AmsBench::Api::V1).as_json
+  ActiveModelSerializers::SerializableResource.new(resource).as_json
+end
+
+def clear_cache
+  AmsBench::PrimaryResourceSerializer.serializers_cache.clear
+  AmsBench::Api::V1::PrimaryResourceSerializer.serializers_cache.clear
+  ActiveModel::Serializer.serializers_cache.clear
+end
+
+configurable = lambda do
+  clear_cache
+  Benchmark.ams('Configurable Lookup Chain', time: time, disable_gc: disable_gc, &serialization)
+end
+
+old = lambda do
+  clear_cache
+  module ActiveModel
+    class Serializer
+      def self.serializer_lookup_chain_for(klass, namespace = nil)
+        chain = []
+
+        resource_class_name = klass.name.demodulize
+        resource_namespace = klass.name.deconstantize
+        serializer_class_name = "#{resource_class_name}Serializer"
+
+        chain.push("#{namespace}::#{serializer_class_name}") if namespace
+        chain.push("#{name}::#{serializer_class_name}") if self != ActiveModel::Serializer
+        chain.push("#{resource_namespace}::#{serializer_class_name}")
+        chain
+      end
+    end
+  end
+
+  Benchmark.ams('Old Lookup Chain (v0.10)', time: time, disable_gc: disable_gc, &serialization)
+end
+
+configurable.call
+old.call
diff --git a/test/support/serialization_testing.rb b/test/support/serialization_testing.rb
index d91ef2b36..524a32976 100644
--- a/test/support/serialization_testing.rb
+++ b/test/support/serialization_testing.rb
@@ -17,6 +17,14 @@ def with_namespace_separator(separator)
     ActiveModelSerializers.config.jsonapi_namespace_separator = original_separator
   end
 
+  def with_prepended_lookup(lookup_proc)
+    original_lookup = ActiveModelSerializers.config.serializer_lookup_cahin
+    ActiveModelSerializers.config.serializer_lookup_chain.unshift lookup_proc
+    yield
+  ensure
+    ActiveModelSerializers.config.serializer_lookup_cahin = original_lookup
+  end
+
   # Aliased as :with_configured_adapter to clarify that
   # this method tests the configured adapter.
   # When not testing configuration, it may be preferable