diff --git a/Lib/test/test_iter.py b/Lib/test/test_iter.py
index a7658b5f476947..0410632e3f753e 100644
--- a/Lib/test/test_iter.py
+++ b/Lib/test/test_iter.py
@@ -2,6 +2,7 @@
 
 import sys
 import unittest
+import gc
 from test.support import run_unittest, cpython_only
 from test.support.os_helper import TESTFN, unlink
 from test.support import check_free_after_iterating, ALWAYS_EQ, NEVER_EQ
@@ -1036,6 +1037,25 @@ def test_error_iter(self):
             self.assertRaises(TypeError, iter, typ())
         self.assertRaises(ZeroDivisionError, iter, BadIterableClass())
 
+    def test_access_result_tuple_while_iterating(self):
+        TAG = object()
+
+        def monitor():
+            lst = [x for x in gc.get_referrers(TAG) if isinstance(x, tuple)]
+            # This would be the result tuple if is accessible mid-iteration
+            t = lst[0]
+            print(t)
+            return t
+
+        def my_iter():
+            yield TAG
+            t = monitor()
+            breakpoint()
+            for x in range(10):
+                yield x
+
+        self.assertRaises(IndexError, tuple, my_iter())
+
 
 def test_main():
     run_unittest(TestCase)
diff --git a/Misc/NEWS.d/next/Core and Builtins/2021-02-12-00-56-06.bpo-15108.KKSAxV.rst b/Misc/NEWS.d/next/Core and Builtins/2021-02-12-00-56-06.bpo-15108.KKSAxV.rst
new file mode 100644
index 00000000000000..d01828a059c41a
--- /dev/null
+++ b/Misc/NEWS.d/next/Core and Builtins/2021-02-12-00-56-06.bpo-15108.KKSAxV.rst	
@@ -0,0 +1,3 @@
+Fixed an issue that could cause a crash when accessing an incomplete tuple
+when collecting an iterable into a :class:`tuple` using :c:func:`PySequence_Tuple`.
+Patch by Pablo Galindo.
diff --git a/Objects/abstract.c b/Objects/abstract.c
index 74a73ee469866d..3354b5558b8755 100644
--- a/Objects/abstract.c
+++ b/Objects/abstract.c
@@ -1993,6 +1993,9 @@ PySequence_Tuple(PyObject *v)
     if (result == NULL)
         goto Fail;
 
+    // bpo-15108: Code can access the result tuple while being
+    // incomplete when calling PyIter_Next().
+    PyObject_GC_UnTrack(result);
     /* Fill the tuple. */
     for (j = 0; ; ++j) {
         PyObject *item = PyIter_Next(it);
@@ -2022,10 +2025,17 @@ PySequence_Tuple(PyObject *v)
                 Py_DECREF(item);
                 goto Fail;
             }
+            // Resizing could track the tuple again
+            PyObject_GC_UnTrack(result);
         }
         PyTuple_SET_ITEM(result, j, item);
     }
 
+    // No more calls can go back into Python, so is safe
+    // to re-track the tuple.
+
+    PyObject_GC_Track(result);
+
     /* Cut tuple back if guess was too large. */
     if (j < n &&
         _PyTuple_Resize(&result, j) != 0)