diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 455e4e0..30be63b 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -130,24 +130,36 @@ jobs:
           - name: default
             tox: default
             dependencies: default
+            qt: false
           - name: PyQt5
             tox: pyqt5
-            dependencies: qt5
+            dependencies: qt
+            qt: true
+            qt-major: 5
+          - name: PyQt6
+            tox: pyqt6
+            dependencies: qt
+            qt: true
+            qt-major: 6
           - name: PySide2
             tox: pyside2
-            dependencies: qt5
+            dependencies: qt
+            qt: true
+            qt-major: 5
+          - name: PySide6
+            tox: pyside6
+            dependencies: qt
+            qt: true
+            qt-major: 6
           - name: asyncio
             tox: asyncio
             dependencies: asyncio
+            qt: false
         exclude:
           - python:
               major: 2
             reactor:
-              tox: pyqt5
-          - python:
-              major: 2
-            reactor:
-              tox: pyside2
+              qt: true
           - python:
               action: "3.11"
             reactor:
@@ -159,11 +171,15 @@ jobs:
           - python:
               implementation: pypy
             reactor:
-              tox: pyqt5
+              qt: true
           - python:
-              implementation: pypy
+              action: "3.5"
             reactor:
-              tox: pyside2
+              qt-major: 6
+          - python:
+              action: "3.6"
+            reactor:
+              qt-major: 6
     steps:
       - uses: actions/checkout@v2
       - name: Enable Problem Matchers
@@ -200,10 +216,10 @@ jobs:
           echo
           pip freeze --all
       - name: Install Linux Qt5 dependencies
-        if: matrix.os.python_platform == 'linux' && matrix.reactor.dependencies == 'qt5'
+        if: matrix.os.python_platform == 'linux' && matrix.reactor.dependencies == 'qt'
         run: |
           apt-get update --yes
-          apt-get install --yes libgl1
+          apt-get install --yes libgl1-mesa-dev libdbus-1-3 libxkbcommon-x11-0 libxcb-cursor0 libxcb-icccm4 libxcb-image0 libxcb-keysyms1 libxcb-randr0 libxcb-render-util0 libxcb-xinerama0 libxcb-xfixes0
       - name: Install
         run: |
           pip install tox
diff --git a/setup.py b/setup.py
index a4aef9c..4b0d6c5 100755
--- a/setup.py
+++ b/setup.py
@@ -18,10 +18,17 @@
     extras_require={
         "dev": ["pre-commit", "black"],
         "pyside2": [
-            # >= 0.6.3 for PySide2 extra version constraints
-            "qt5reactor[pyside2]>=0.6.3",
+            "qt5reactor[pyside2] @ git+https://github.com/twisted/qt5reactor@master",
+        ],
+        "pyside6": [
+            "qt5reactor[pyside6] @ git+https://github.com/twisted/qt5reactor@master",
+        ],
+        "pyqt5": [
+            "qt5reactor[pyqt5] @ git+https://github.com/twisted/qt5reactor@master",
+        ],
+        "pyqt6": [
+            "qt5reactor[pyqt6] @ git+https://github.com/twisted/qt5reactor@master",
         ],
-        "pyqt5": ["qt5reactor[pyqt5]>=0.6.2"],
     },
     classifiers=[
         "Development Status :: 5 - Production/Stable",
diff --git a/tox.ini b/tox.ini
index addfca7..97e44e0 100644
--- a/tox.ini
+++ b/tox.ini
@@ -3,7 +3,9 @@ envlist=
     py{27,py27,35,36,37,38,39,310,311,py37,py38,py39}-defaultreactor
     py{35,36,37,38,39,310,311,py37,py38,py39}-asyncioreactor
     py{35,36,37,38,39,310,311}-pyqt5reactor
+    py{35,36,37,38,39,310,311}-pyqt6reactor
     py{35,36,37,38,39,310,311}-pyside2reactor
+    py{35,36,37,38,39,310,311}-pyside6reactor
     linting
 
 [testenv]
@@ -12,16 +14,20 @@ deps=
     pytest
     twisted
     py37,py38,py39,pypy37,pypy38: hypothesis
-    pyqt5reactor,pyside2reactor: pytest-qt
-    pyqt5reactor,pyside2reactor: pytest-xvfb
-    pyqt5reactor,pyside2reactor: pywin32; sys_platform == 'win32'
+    pyqt5reactor,pyqt6reactor,pyside2reactor,pyside6reactor: pytest-qt
+    pyqt5reactor,pyqt6reactor,pyside2reactor,pyside6reactor: pytest-xvfb
+    pyqt5reactor,pyqt6reactor,pyside2reactor,pyside6reactor: pywin32; sys_platform == 'win32'
 extras=
     pyqt5reactor: pyqt5
+    pyqt6reactor: pyqt6
     pyside2reactor: pyside2
+    pyside6reactor: pyside6
 setenv=
     defaultreactor: REACTOR = default
     pyqt5reactor: REACTOR = qt5reactor
+    pyqt6reactor: REACTOR = qt5reactor
     pyside2reactor: REACTOR = qt5reactor
+    pyside6reactor: REACTOR = qt5reactor
     asyncioreactor: REACTOR = asyncio
 commands=
     pytest --reactor={env:REACTOR}