diff --git a/.changeset/easy-suits-mate.md b/.changeset/easy-suits-mate.md
new file mode 100644
index 00000000000..f4e8f19d4c1
--- /dev/null
+++ b/.changeset/easy-suits-mate.md
@@ -0,0 +1,5 @@
+---
+'@primer/react': patch
+---
+
+Replaces 'aria-live' usage and removes internal LiveRegion component
diff --git a/packages/react/src/DataTable/Pagination.tsx b/packages/react/src/DataTable/Pagination.tsx
index c58bf6375ec..950838a5638 100644
--- a/packages/react/src/DataTable/Pagination.tsx
+++ b/packages/react/src/DataTable/Pagination.tsx
@@ -2,7 +2,7 @@ import {ChevronLeftIcon, ChevronRightIcon} from '@primer/octicons-react'
 import type React from 'react'
 import {useCallback, useMemo, useState} from 'react'
 import {Button} from '../internal/components/ButtonReset'
-import {LiveRegion, LiveRegionOutlet, Message} from '../internal/components/LiveRegion'
+import {AriaStatus} from '../live-region'
 import {VisuallyHidden} from '../VisuallyHidden'
 import {warning} from '../utils/warning'
 import type {ResponsiveValue} from '../hooks/useResponsiveValue'
@@ -99,72 +99,69 @@ export function Pagination({
   }, [pageCount, pageIndex, showPages])
 
   return (
-    <LiveRegion>
-      <LiveRegionOutlet />
-      <nav aria-label={label} className={clsx('TablePagination', classes.TablePagination)} id={id}>
-        <Range pageStart={pageStart} pageEnd={pageEnd} totalCount={totalCount} />
-        <ol
-          className={clsx('TablePaginationSteps', classes.TablePaginationSteps)}
-          data-hidden-viewport-ranges={getViewportRangesToHidePages().join(' ')}
-        >
-          <Step>
-            <Button
-              className={clsx('TablePaginationAction', classes.TablePaginationAction)}
-              type="button"
-              data-has-page={hasPreviousPage ? true : undefined}
-              aria-disabled={!hasPreviousPage ? true : undefined}
-              onClick={() => {
-                if (!hasPreviousPage) {
-                  return
-                }
-                selectPreviousPage()
-              }}
-            >
-              {hasPreviousPage ? <ChevronLeftIcon /> : null}
-              <span>Previous</span>
-              <VisuallyHidden>&nbsp;page</VisuallyHidden>
-            </Button>
-          </Step>
-          {model.map((page, i) => {
-            if (page.type === 'BREAK') {
-              return <TruncationStep key={`truncation-${i}`} />
-            } else if (page.type === 'NUM') {
-              return (
-                <Step key={i}>
-                  <Page
-                    active={!!page.selected}
-                    onClick={() => {
-                      selectPage(page.num - 1)
-                    }}
-                  >
-                    {page.num}
-                    {page.precedesBreak ? <VisuallyHidden>…</VisuallyHidden> : null}
-                  </Page>
-                </Step>
-              )
-            }
-          })}
-          <Step>
-            <Button
-              className={clsx('TablePaginationAction', classes.TablePaginationAction)}
-              type="button"
-              data-has-page={hasNextPage ? true : undefined}
-              aria-disabled={!hasNextPage ? true : undefined}
-              onClick={() => {
-                if (!hasNextPage) {
-                  return
-                }
-                selectNextPage()
-              }}
-            >
-              <span>Next</span>
-              <VisuallyHidden>&nbsp;page</VisuallyHidden>
-              {hasNextPage ? <ChevronRightIcon /> : null}
-            </Button>
-          </Step>
-        </ol>
-      </nav>
-    </LiveRegion>
+    <nav aria-label={label} className={clsx('TablePagination', classes.TablePagination)} id={id}>
+      <Range pageStart={pageStart} pageEnd={pageEnd} totalCount={totalCount} />
+      <ol
+        className={clsx('TablePaginationSteps', classes.TablePaginationSteps)}
+        data-hidden-viewport-ranges={getViewportRangesToHidePages().join(' ')}
+      >
+        <Step>
+          <Button
+            className={clsx('TablePaginationAction', classes.TablePaginationAction)}
+            type="button"
+            data-has-page={hasPreviousPage ? true : undefined}
+            aria-disabled={!hasPreviousPage ? true : undefined}
+            onClick={() => {
+              if (!hasPreviousPage) {
+                return
+              }
+              selectPreviousPage()
+            }}
+          >
+            {hasPreviousPage ? <ChevronLeftIcon /> : null}
+            <span>Previous</span>
+            <VisuallyHidden>&nbsp;page</VisuallyHidden>
+          </Button>
+        </Step>
+        {model.map((page, i) => {
+          if (page.type === 'BREAK') {
+            return <TruncationStep key={`truncation-${i}`} />
+          } else if (page.type === 'NUM') {
+            return (
+              <Step key={i}>
+                <Page
+                  active={!!page.selected}
+                  onClick={() => {
+                    selectPage(page.num - 1)
+                  }}
+                >
+                  {page.num}
+                  {page.precedesBreak ? <VisuallyHidden>…</VisuallyHidden> : null}
+                </Page>
+              </Step>
+            )
+          }
+        })}
+        <Step>
+          <Button
+            className={clsx('TablePaginationAction', classes.TablePaginationAction)}
+            type="button"
+            data-has-page={hasNextPage ? true : undefined}
+            aria-disabled={!hasNextPage ? true : undefined}
+            onClick={() => {
+              if (!hasNextPage) {
+                return
+              }
+              selectNextPage()
+            }}
+          >
+            <span>Next</span>
+            <VisuallyHidden>&nbsp;page</VisuallyHidden>
+            {hasNextPage ? <ChevronRightIcon /> : null}
+          </Button>
+        </Step>
+      </ol>
+    </nav>
   )
 }
 
@@ -179,7 +176,11 @@ function Range({pageStart, pageEnd, totalCount}: RangeProps) {
   const end = pageEnd
   return (
     <>
-      <Message value={`Showing ${start} through ${end} of ${totalCount}`} />
+      <VisuallyHidden>
+        <AriaStatus>
+          Showing {start} through {end} of {totalCount}
+        </AriaStatus>
+      </VisuallyHidden>
       <p className={clsx('TablePaginationRange', classes.TablePaginationRange)}>
         {start}
         <VisuallyHidden>&nbsp;through&nbsp;</VisuallyHidden>
diff --git a/packages/react/src/Skeleton/Skeleton.examples.stories.tsx b/packages/react/src/Skeleton/Skeleton.examples.stories.tsx
index 641c863b6b1..acc83622da8 100644
--- a/packages/react/src/Skeleton/Skeleton.examples.stories.tsx
+++ b/packages/react/src/Skeleton/Skeleton.examples.stories.tsx
@@ -7,6 +7,7 @@ import {SkeletonAvatar} from '../SkeletonAvatar'
 import {VisuallyHidden} from '../VisuallyHidden'
 import {KebabHorizontalIcon} from '@primer/octicons-react'
 import classes from './Skeleton.examples.stories.module.css'
+import {AriaStatus} from '../experimental'
 
 export default {
   title: 'Components/Skeleton/Examples',
@@ -42,7 +43,9 @@ export const CommentsLoading = () => {
       {/** read by screen readers in place of the comments in a skeleton loading state */}
       {loading ? <VisuallyHidden>Comments are loading</VisuallyHidden> : null}
       {/** when loading is completed, it should be announced by the screen-reader */}
-      <VisuallyHidden aria-live="polite">{loadingFinished ? 'Comments are loaded' : null}</VisuallyHidden>
+      <VisuallyHidden>
+        <AriaStatus>{loadingFinished ? 'Comments are loaded' : null}</AriaStatus>
+      </VisuallyHidden>
       <div className={classes.CommentsSpacing}>
         <Button onClick={toggleLoadingState}>{loading ? 'Stop loading' : 'Start loading'}</Button>
         {Array.from({length: COMMENT_LIST_LENGTH}, (_, index) => (
@@ -101,7 +104,9 @@ export const CommentsLoadingWithSuspense = () => {
       {/** read by screen readers in place of the comments in a skeleton loading state */}
       {loadingStatus === 'pending' ? <VisuallyHidden>Comments are loading</VisuallyHidden> : null}
       {/** when loading is completed, it should be announced by the screen-reader */}
-      <VisuallyHidden aria-live="polite">{loadingStatus === 'fulfilled' ? 'Comments are loaded' : null}</VisuallyHidden>
+      <VisuallyHidden>
+        <AriaStatus>{loadingStatus === 'fulfilled' ? 'Comments are loaded' : null}</AriaStatus>
+      </VisuallyHidden>
 
       {/* aria-busy is passed so the screenreader doesn't announce the skeleton state */}
       <div className={classes.CommentsSpacing} aria-busy={loadingStatus === 'pending'}>
diff --git a/packages/react/src/TreeView/TreeView.test.tsx b/packages/react/src/TreeView/TreeView.test.tsx
index 240d67b078c..f0d2d77f8ad 100644
--- a/packages/react/src/TreeView/TreeView.test.tsx
+++ b/packages/react/src/TreeView/TreeView.test.tsx
@@ -5,6 +5,7 @@ import React from 'react'
 import type {SubTreeState} from './TreeView'
 import {TreeView} from './TreeView'
 import {GearIcon} from '@primer/octicons-react'
+import {getLiveRegion} from '../live-region/__tests__/test-helpers'
 
 // TODO: Move this function into a shared location
 function renderWithTheme(
@@ -1391,7 +1392,14 @@ describe('State', () => {
 })
 
 describe('Asynchronous loading', () => {
-  it('updates aria live region when loading is done', () => {
+  afterEach(() => {
+    const liveRegion = document.querySelector('live-region')
+    if (liveRegion) {
+      document.body.removeChild(liveRegion)
+    }
+  })
+
+  it('updates aria live region when loading is done', async () => {
     function TestTree() {
       const [state, setState] = React.useState<SubTreeState>('initial')
 
@@ -1423,29 +1431,33 @@ describe('Asynchronous loading', () => {
         </div>
       )
     }
+    const user = userEvent.setup()
     const {getByRole} = renderWithTheme(<TestTree />)
 
     const doneButton = getByRole('button', {name: 'Load'})
-    const liveRegion = getByRole('status')
+    const liveRegion = getLiveRegion()
 
     // Live region should be empty
-    expect(liveRegion).toHaveTextContent('')
+    expect(liveRegion.getMessage('polite')).toBe('')
 
     // Click load button to mimic async loading
-    fireEvent.click(doneButton)
+    await act(async () => {
+      await user.click(doneButton)
+    })
 
-    expect(liveRegion).toHaveTextContent('Parent content loading')
+    expect(liveRegion.getMessage('polite')).toBe('Parent content loading')
 
     // Click done button to mimic the completion of async loading
-    fireEvent.click(doneButton)
+    await act(async () => {
+      await user.click(doneButton)
+    })
 
     act(() => {
       vi.runAllTimers()
     })
 
     // Live region should be updated
-    expect(liveRegion).not.toHaveTextContent('Child 2 is empty')
-    expect(liveRegion).toHaveTextContent('Parent content loaded')
+    expect(liveRegion.getMessage('polite')).toBe('Parent content loaded')
   })
 
   it('moves focus from loading item to first child', async () => {
@@ -1810,7 +1822,8 @@ describe('CSS Module Migration', () => {
       </TreeView>
     )
 
-    // Testing on the second child element because the first child element is visually hidden
-    expect(render(<TreeViewTestComponent />).container.children[1]).toHaveClass('test-class-name')
+    // Find the TreeView ul element (which should have the className)
+    const treeElement = render(<TreeViewTestComponent />).getByRole('tree')
+    expect(treeElement).toHaveClass('test-class-name')
   })
 })
diff --git a/packages/react/src/TreeView/TreeView.tsx b/packages/react/src/TreeView/TreeView.tsx
index 86100c9cbce..c10d740513a 100644
--- a/packages/react/src/TreeView/TreeView.tsx
+++ b/packages/react/src/TreeView/TreeView.tsx
@@ -29,6 +29,7 @@ import {useIsMacOS} from '../hooks'
 import {Tooltip} from '../TooltipV2'
 import {isSlot} from '../utils/is-slot'
 import type {FCWithSlotMarker} from '../utils/types'
+import {AriaStatus} from '../live-region'
 
 // ----------------------------------------------------------------------------
 // Context
@@ -144,8 +145,8 @@ const Root: React.FC<TreeViewProps> = ({
       }}
     >
       <>
-        <VisuallyHidden role="status" aria-live="polite" aria-atomic="true">
-          {ariaLiveMessage}
+        <VisuallyHidden>
+          <AriaStatus announceOnShow>{ariaLiveMessage}</AriaStatus>
         </VisuallyHidden>
         <ul
           ref={containerRef}
diff --git a/packages/react/src/experimental/SelectPanel2/SelectPanel.tsx b/packages/react/src/experimental/SelectPanel2/SelectPanel.tsx
index d3b2e7a988d..3e61548d52b 100644
--- a/packages/react/src/experimental/SelectPanel2/SelectPanel.tsx
+++ b/packages/react/src/experimental/SelectPanel2/SelectPanel.tsx
@@ -595,9 +595,11 @@ const SelectPanelMessage: React.FC<SelectPanelMessageProps> = ({
   title,
   children,
 }) => {
+  const MessageWrapper = variant === 'empty' ? 'div' : AriaStatus
+
   if (size === 'full') {
     return (
-      <div aria-live={variant === 'empty' ? undefined : 'polite'} className={classes.MessageFull}>
+      <MessageWrapper className={classes.MessageFull}>
         {variant !== 'empty' ? (
           <Octicon
             icon={AlertIcon}
@@ -610,18 +612,14 @@ const SelectPanelMessage: React.FC<SelectPanelMessageProps> = ({
         ) : null}
         <span className={classes.MessageTitle}>{title}</span>
         <span className={classes.MessageContent}>{children}</span>
-      </div>
+      </MessageWrapper>
     )
   } else {
     return (
-      <div
-        aria-live={variant === 'empty' ? undefined : 'polite'}
-        className={classes.MessageInline}
-        data-variant={variant}
-      >
+      <MessageWrapper className={classes.MessageInline} data-variant={variant}>
         <AlertIcon size={16} />
         <div>{children}</div>
-      </div>
+      </MessageWrapper>
     )
   }
 }
diff --git a/packages/react/src/internal/components/LiveRegion.tsx b/packages/react/src/internal/components/LiveRegion.tsx
deleted file mode 100644
index 0bf93a6a8fb..00000000000
--- a/packages/react/src/internal/components/LiveRegion.tsx
+++ /dev/null
@@ -1,71 +0,0 @@
-import React from 'react'
-import {VisuallyHidden} from '../../VisuallyHidden'
-
-type LiveRegionContext = {
-  announce: (message: string) => void
-  message: string
-}
-
-const LiveRegionContext = React.createContext<LiveRegionContext | null>(null)
-
-function useLiveRegion() {
-  const context = React.useContext(LiveRegionContext)
-  if (!context) {
-    throw new Error('useLiveRegion() must be used within a <LiveRegion>')
-  }
-  return context
-}
-
-function LiveRegion({children}: React.PropsWithChildren) {
-  const [message, setMessage] = React.useState('')
-  const value = React.useMemo(() => {
-    return {
-      announce: setMessage,
-      message,
-    }
-  }, [message])
-
-  return <LiveRegionContext.Provider value={value}>{children}</LiveRegionContext.Provider>
-}
-
-function LiveRegionOutlet() {
-  const liveRegion = useLiveRegion()
-  return (
-    <VisuallyHidden role="status" aria-live="polite" aria-atomic={true}>
-      {liveRegion.message}
-    </VisuallyHidden>
-  )
-}
-
-function Message({value}: {value: string}) {
-  const liveRegion = useLiveRegion()
-  const savedLiveRegion = React.useRef(liveRegion)
-  const committedRef = React.useRef(false)
-
-  React.useEffect(() => {
-    savedLiveRegion.current = liveRegion
-  }, [liveRegion])
-
-  React.useEffect(() => {
-    if (committedRef.current !== true) {
-      return
-    }
-    const timeoutId = setTimeout(() => {
-      savedLiveRegion.current.announce(value)
-    }, 750)
-    return () => {
-      clearTimeout(timeoutId)
-    }
-  }, [value])
-
-  React.useEffect(() => {
-    committedRef.current = true
-    return () => {
-      committedRef.current = false
-    }
-  }, [])
-
-  return null
-}
-
-export {LiveRegion, LiveRegionOutlet, Message, useLiveRegion}