diff --git a/.changeset/clever-parents-bathe.md b/.changeset/clever-parents-bathe.md
deleted file mode 100644
index 083645355df..00000000000
--- a/.changeset/clever-parents-bathe.md
+++ /dev/null
@@ -1,7 +0,0 @@
----
-'@primer/react': patch
----
-
-Update @react-aria/ssr dependency to ^3.5.0 to address server-side rendering mismatch when using React StrictMode
-
-<!-- Changed components: FormControl -->
diff --git a/.changeset/eleven-humans-sneeze.md b/.changeset/eleven-humans-sneeze.md
new file mode 100644
index 00000000000..e881e43ce14
--- /dev/null
+++ b/.changeset/eleven-humans-sneeze.md
@@ -0,0 +1,5 @@
+---
+"@primer/react": patch
+---
+
+PageLayout.Content no longer renders as `main` by default. Instead, developers may add a `main` landmark within `Pagelayout.Content` themselves.
diff --git a/package-lock.json b/package-lock.json
index bf5b7875e61..a6dd6bdcedc 100644
--- a/package-lock.json
+++ b/package-lock.json
@@ -17,7 +17,7 @@
         "@primer/behaviors": "^1.3.4",
         "@primer/octicons-react": "^19.3.0",
         "@primer/primitives": "^7.11.11",
-        "@react-aria/ssr": "^3.5.0",
+        "@react-aria/ssr": "^3.1.0",
         "@styled-system/css": "^5.1.5",
         "@styled-system/props": "^5.1.5",
         "@styled-system/theme-get": "^5.1.2",
diff --git a/package.json b/package.json
index 913dc6a6ff9..d5105e32b8b 100644
--- a/package.json
+++ b/package.json
@@ -102,7 +102,7 @@
     "@primer/behaviors": "^1.3.4",
     "@primer/octicons-react": "^19.3.0",
     "@primer/primitives": "^7.11.11",
-    "@react-aria/ssr": "^3.5.0",
+    "@react-aria/ssr": "^3.1.0",
     "@styled-system/css": "^5.1.5",
     "@styled-system/props": "^5.1.5",
     "@styled-system/theme-get": "^5.1.2",
diff --git a/src/PageLayout/PageLayout.test.tsx b/src/PageLayout/PageLayout.test.tsx
index 03abd241912..46a6da2beb3 100644
--- a/src/PageLayout/PageLayout.test.tsx
+++ b/src/PageLayout/PageLayout.test.tsx
@@ -123,7 +123,9 @@ describe('PageLayout', () => {
       <ThemeProvider>
         <PageLayout>
           <PageLayout.Header aria-label="Header">Header</PageLayout.Header>
-          <PageLayout.Content aria-label="Content">Content</PageLayout.Content>
+          <PageLayout.Content>
+            <main aria-label="Content">Content</main>
+          </PageLayout.Content>
           <PageLayout.Pane>Pane</PageLayout.Pane>
           <PageLayout.Footer aria-label="Footer">Footer</PageLayout.Footer>
         </PageLayout>
@@ -154,7 +156,7 @@ describe('PageLayout', () => {
     )
 
     expect(screen.getByRole('banner')).toHaveAccessibleName('header')
-    expect(screen.getByRole('main')).toHaveAccessibleName('content')
+    expect(screen.getByLabelText('content')).toBeInTheDocument()
     expect(screen.getByRole('contentinfo')).toHaveAccessibleName('footer')
   })
 
diff --git a/src/PageLayout/PageLayout.tsx b/src/PageLayout/PageLayout.tsx
index 71371fc4233..54af5598b73 100644
--- a/src/PageLayout/PageLayout.tsx
+++ b/src/PageLayout/PageLayout.tsx
@@ -421,7 +421,6 @@ const Content: React.FC<React.PropsWithChildren<PageLayoutContentProps>> = ({
 
   return (
     <Box
-      as="main"
       aria-label={label}
       aria-labelledby={labelledBy}
       sx={merge<BetterSystemStyleObject>(
diff --git a/src/PageLayout/__snapshots__/PageLayout.test.tsx.snap b/src/PageLayout/__snapshots__/PageLayout.test.tsx.snap
index 97b5bfbea64..30144461b0c 100644
--- a/src/PageLayout/__snapshots__/PageLayout.test.tsx.snap
+++ b/src/PageLayout/__snapshots__/PageLayout.test.tsx.snap
@@ -199,7 +199,7 @@ exports[`PageLayout renders condensed layout 1`] = `
       <div
         class="c5"
       >
-        <main
+        <div
           class="c6"
         >
           <div
@@ -213,7 +213,7 @@ exports[`PageLayout renders condensed layout 1`] = `
           <div
             class=""
           />
-        </main>
+        </div>
         <div
           class="c8"
         >
@@ -493,7 +493,7 @@ exports[`PageLayout renders default layout 1`] = `
       <div
         class="c5"
       >
-        <main
+        <div
           class="c6"
         >
           <div
@@ -507,7 +507,7 @@ exports[`PageLayout renders default layout 1`] = `
           <div
             class=""
           />
-        </main>
+        </div>
         <div
           class="c8"
         >
@@ -787,7 +787,7 @@ exports[`PageLayout renders pane in different position when narrow 1`] = `
       <div
         class="c5"
       >
-        <main
+        <div
           class="c6"
         >
           <div
@@ -801,7 +801,7 @@ exports[`PageLayout renders pane in different position when narrow 1`] = `
           <div
             class=""
           />
-        </main>
+        </div>
         <div
           class="c8"
         >
@@ -1081,7 +1081,7 @@ exports[`PageLayout renders with dividers 1`] = `
       <div
         class="c5"
       >
-        <main
+        <div
           class="c6"
         >
           <div
@@ -1095,7 +1095,7 @@ exports[`PageLayout renders with dividers 1`] = `
           <div
             class=""
           />
-        </main>
+        </div>
         <div
           class="c8"
         >
diff --git a/src/SplitPageLayout/__snapshots__/SplitPageLayout.test.tsx.snap b/src/SplitPageLayout/__snapshots__/SplitPageLayout.test.tsx.snap
index c35d5dc97cd..1486e3792bb 100644
--- a/src/SplitPageLayout/__snapshots__/SplitPageLayout.test.tsx.snap
+++ b/src/SplitPageLayout/__snapshots__/SplitPageLayout.test.tsx.snap
@@ -234,7 +234,7 @@ exports[`SplitPageLayout renders default layout 1`] = `
       <div
         class="c5"
       >
-        <main
+        <div
           class="c6"
         >
           <div
@@ -248,7 +248,7 @@ exports[`SplitPageLayout renders default layout 1`] = `
           <div
             class=""
           />
-        </main>
+        </div>
         <div
           class="c8"
         >