diff --git a/.changeset/silly-plants-draw.md b/.changeset/silly-plants-draw.md
new file mode 100644
index 00000000000..5231b92bad0
--- /dev/null
+++ b/.changeset/silly-plants-draw.md
@@ -0,0 +1,5 @@
+---
+"@primer/react": patch
+---
+
+Recalculate autocomplete suggestions if the input data changes while the menu is open
diff --git a/src/drafts/MarkdownEditor/_MarkdownInput.tsx b/src/drafts/MarkdownEditor/_MarkdownInput.tsx
index 71897ea389f..6b78f2e5892 100644
--- a/src/drafts/MarkdownEditor/_MarkdownInput.tsx
+++ b/src/drafts/MarkdownEditor/_MarkdownInput.tsx
@@ -30,6 +30,8 @@ interface MarkdownInputProps extends Omit<TextareaProps, 'onChange'> {
   visible: boolean
 }
 
+const emptyArray: [] = [] // constant reference to avoid re-running effects
+
 export const MarkdownInput = forwardRef<HTMLTextAreaElement, MarkdownInputProps>(
   (
     {
@@ -55,15 +57,16 @@ export const MarkdownInput = forwardRef<HTMLTextAreaElement, MarkdownInputProps>
     forwardedRef,
   ) => {
     const [suggestions, setSuggestions] = useState<Suggestions | null>(null)
+    const [event, setEvent] = useState<ShowSuggestionsEvent | null>(null)
 
     const {trigger: emojiTrigger, calculateSuggestions: calculateEmojiSuggestions} = useEmojiSuggestions(
-      emojiSuggestions ?? [],
+      emojiSuggestions ?? emptyArray,
     )
     const {trigger: mentionsTrigger, calculateSuggestions: calculateMentionSuggestions} = useMentionSuggestions(
-      mentionSuggestions ?? [],
+      mentionSuggestions ?? emptyArray,
     )
     const {trigger: referencesTrigger, calculateSuggestions: calculateReferenceSuggestions} = useReferenceSuggestions(
-      referenceSuggestions ?? [],
+      referenceSuggestions ?? emptyArray,
     )
 
     const triggers = useMemo(
@@ -71,17 +74,45 @@ export const MarkdownInput = forwardRef<HTMLTextAreaElement, MarkdownInputProps>
       [mentionsTrigger, referencesTrigger, emojiTrigger],
     )
 
-    const onShowSuggestions = async (event: ShowSuggestionsEvent) => {
-      setSuggestions('loading')
-      if (event.trigger.triggerChar === emojiTrigger.triggerChar) {
-        setSuggestions(await calculateEmojiSuggestions(event.query))
-      } else if (event.trigger.triggerChar === mentionsTrigger.triggerChar) {
-        setSuggestions(await calculateMentionSuggestions(event.query))
-      } else if (event.trigger.triggerChar === referencesTrigger.triggerChar) {
-        setSuggestions(await calculateReferenceSuggestions(event.query))
-      }
+    const lastEventRef = useRef<ShowSuggestionsEvent | null>(null)
+
+    const onHideSuggestions = () => {
+      setEvent(null)
+      setSuggestions(null) // the effect would do this anyway, but this allows React to batch the update
     }
 
+    // running the calculation in an effect (rather than in the onShowSuggestions handler) allows us
+    // to automatically recalculate if the suggestions change while the menu is open
+    useEffect(() => {
+      if (!event) {
+        setSuggestions(null)
+        return
+      }
+
+      // (prettier vs. eslint conflict)
+      // eslint-disable-next-line @typescript-eslint/no-extra-semi
+      ;(async function () {
+        lastEventRef.current = event
+        setSuggestions('loading')
+        if (event.trigger.triggerChar === emojiTrigger.triggerChar) {
+          setSuggestions(await calculateEmojiSuggestions(event.query))
+        } else if (event.trigger.triggerChar === mentionsTrigger.triggerChar) {
+          setSuggestions(await calculateMentionSuggestions(event.query))
+        } else if (event.trigger.triggerChar === referencesTrigger.triggerChar) {
+          setSuggestions(await calculateReferenceSuggestions(event.query))
+        }
+      })()
+    }, [
+      event,
+      calculateEmojiSuggestions,
+      calculateMentionSuggestions,
+      calculateReferenceSuggestions,
+      // The triggers never actually change because they are statically defined
+      emojiTrigger,
+      mentionsTrigger,
+      referencesTrigger,
+    ])
+
     const ref = useRef<HTMLTextAreaElement>(null)
     useRefObjectAsForwardedRef(forwardedRef, ref)
 
@@ -99,8 +130,8 @@ export const MarkdownInput = forwardRef<HTMLTextAreaElement, MarkdownInputProps>
       <InlineAutocomplete
         triggers={triggers}
         suggestions={suggestions}
-        onShowSuggestions={e => onShowSuggestions(e)}
-        onHideSuggestions={() => setSuggestions(null)}
+        onShowSuggestions={setEvent}
+        onHideSuggestions={onHideSuggestions}
         sx={{flex: 'auto'}}
         tabInsertsSuggestions
       >
diff --git a/src/drafts/MarkdownEditor/suggestions/_useEmojiSuggestions.tsx b/src/drafts/MarkdownEditor/suggestions/_useEmojiSuggestions.tsx
index ec3108f1387..7c40dd82230 100644
--- a/src/drafts/MarkdownEditor/suggestions/_useEmojiSuggestions.tsx
+++ b/src/drafts/MarkdownEditor/suggestions/_useEmojiSuggestions.tsx
@@ -1,4 +1,4 @@
-import React from 'react'
+import React, {useMemo} from 'react'
 import {suggestionsCalculator, UseSuggestionsHook} from '.'
 import {ActionList} from '../../../ActionList'
 import {Suggestion, Trigger} from '../../InlineAutocomplete'
@@ -56,7 +56,13 @@ const scoreSuggestion = (query: string, emoji: Emoji): number => {
   return score
 }
 
-export const useEmojiSuggestions: UseSuggestionsHook<Emoji> = emojis => ({
-  calculateSuggestions: suggestionsCalculator(emojis, scoreSuggestion, emojiToSugggestion),
-  trigger,
-})
+export const useEmojiSuggestions: UseSuggestionsHook<Emoji> = emojis => {
+  const calculateSuggestions = useMemo(
+    () => suggestionsCalculator(emojis, scoreSuggestion, emojiToSugggestion),
+    [emojis],
+  )
+  return {
+    calculateSuggestions,
+    trigger,
+  }
+}
diff --git a/src/drafts/MarkdownEditor/suggestions/_useMentionSuggestions.tsx b/src/drafts/MarkdownEditor/suggestions/_useMentionSuggestions.tsx
index b3ecb41ea4a..386b4e4165e 100644
--- a/src/drafts/MarkdownEditor/suggestions/_useMentionSuggestions.tsx
+++ b/src/drafts/MarkdownEditor/suggestions/_useMentionSuggestions.tsx
@@ -1,5 +1,5 @@
 import {score} from 'fzy.js'
-import React from 'react'
+import React, {useMemo} from 'react'
 import {suggestionsCalculator, UseSuggestionsHook} from '.'
 import {ActionList} from '../../../ActionList'
 import {Suggestion, Trigger} from '../../InlineAutocomplete'
@@ -37,7 +37,13 @@ const scoreSuggestion = (query: string, mentionable: Mentionable): number => {
   return fzyScore
 }
 
-export const useMentionSuggestions: UseSuggestionsHook<Mentionable> = mentionables => ({
-  calculateSuggestions: suggestionsCalculator(mentionables, scoreSuggestion, mentionableToSuggestion),
-  trigger,
-})
+export const useMentionSuggestions: UseSuggestionsHook<Mentionable> = mentionables => {
+  const calculateSuggestions = useMemo(
+    () => suggestionsCalculator(mentionables, scoreSuggestion, mentionableToSuggestion),
+    [mentionables],
+  )
+  return {
+    calculateSuggestions,
+    trigger,
+  }
+}
diff --git a/src/drafts/MarkdownEditor/suggestions/_useReferenceSuggestions.tsx b/src/drafts/MarkdownEditor/suggestions/_useReferenceSuggestions.tsx
index 46f89269f52..efd97c4f582 100644
--- a/src/drafts/MarkdownEditor/suggestions/_useReferenceSuggestions.tsx
+++ b/src/drafts/MarkdownEditor/suggestions/_useReferenceSuggestions.tsx
@@ -1,4 +1,4 @@
-import React from 'react'
+import React, {useMemo} from 'react'
 import {suggestionsCalculator, UseSuggestionsHook} from '.'
 import {ActionList} from '../../../ActionList'
 import {Suggestion, Trigger} from '../../InlineAutocomplete'
@@ -51,10 +51,16 @@ const scoreSuggestion = (query: string, reference: Reference): number => {
   return fzyScore === Infinity ? -Infinity : fzyScore
 }
 
-export const useReferenceSuggestions: UseSuggestionsHook<Reference> = references => ({
-  calculateSuggestions: async (query: string) => {
-    if (/^\d+\s/.test(query)) return [] // don't return anything if the query is in the form #123 ..., assuming they already have the number they want
-    return suggestionsCalculator(references, scoreSuggestion, referenceToSuggestion)(query)
-  },
-  trigger,
-})
+export const useReferenceSuggestions: UseSuggestionsHook<Reference> = references => {
+  const calculateSuggestions = useMemo(() => {
+    const calculator = suggestionsCalculator(references, scoreSuggestion, referenceToSuggestion)
+    return async (query: string) => {
+      if (/^\d+\s/.test(query)) return [] // don't return anything if the query is in the form #123 ..., assuming they already have the number they want
+      return calculator(query)
+    }
+  }, [references])
+  return {
+    calculateSuggestions,
+    trigger,
+  }
+}