diff --git a/looper/utils.py b/looper/utils.py
index aaee2333..1ba6af9e 100644
--- a/looper/utils.py
+++ b/looper/utils.py
@@ -605,7 +605,7 @@ def is_registry_path(input_string: str) -> bool:
     :return bool: True if input is a registry path
     """
     try:
-        if input_string.endswith(".yaml"):
+        if input_string.endswith(".yaml") or input_string.endswith(".csv"):
             return False
     except AttributeError:
         raise RegistryPathException(
diff --git a/tests/conftest.py b/tests/conftest.py
index ac8f71a2..0293bd80 100644
--- a/tests/conftest.py
+++ b/tests/conftest.py
@@ -230,6 +230,24 @@ def prep_temp_pep_basic(example_pep_piface_path):
     return path_to_looper_config
 
 
+@pytest.fixture
+def prep_temp_pep_csv(example_pep_piface_path):
+
+    # Get Path to local copy of hello_looper
+    hello_looper_dir_path = os.path.join(
+        example_pep_piface_path, "hello_looper-dev_derive"
+    )
+
+    # Make local temp copy of hello_looper
+    d = tempfile.mkdtemp()
+    shutil.copytree(hello_looper_dir_path, d, dirs_exist_ok=True)
+
+    advanced_dir = os.path.join(d, "csv")
+    path_to_looper_config = os.path.join(advanced_dir, ".looper.yaml")
+
+    return path_to_looper_config
+
+
 @pytest.fixture
 def prep_temp_config_with_pep(example_pep_piface_path):
     # temp dir
diff --git a/tests/smoketests/test_run.py b/tests/smoketests/test_run.py
index ee1d54cc..18c10f98 100644
--- a/tests/smoketests/test_run.py
+++ b/tests/smoketests/test_run.py
@@ -23,6 +23,16 @@ def test_cli(prep_temp_pep):
         raise pytest.fail("DID RAISE {0}".format(Exception))
 
 
+def test_running_csv_pep(prep_temp_pep_csv):
+    tp = prep_temp_pep_csv
+
+    x = ["run", "--looper-config", tp, "--dry-run"]
+    try:
+        main(test_args=x)
+    except Exception:
+        raise pytest.fail("DID RAISE {0}".format(Exception))
+
+
 def is_connected():
     """Determines if local machine can connect to the internet."""
     import socket
@@ -597,3 +607,14 @@ def test_init_project_using_dict(self, prep_temp_config_with_pep):
         )
 
         assert len(init_project.pipeline_interfaces) == 3
+
+    def test_init_project_using_csv(self, prep_temp_pep_csv):
+        """Verify looper runs using pephub in a basic case and return code is 0"""
+        tp = prep_temp_pep_csv
+        with mod_yaml_data(tp) as config_data:
+            pep_config_csv = config_data["pep_config"]
+
+        pep_config_csv = os.path.join(os.path.dirname(tp), pep_config_csv)
+        init_project = Project(cfg=pep_config_csv)
+
+        assert len(init_project.samples) == 2