diff --git a/Dockerfile b/Dockerfile
index e41d3671b0a..6e6c86c6eec 100644
--- a/Dockerfile
+++ b/Dockerfile
@@ -33,8 +33,17 @@ ENV FEATURES=$FEATURES
 RUN cargo chef cook --profile $BUILD_PROFILE --features "$FEATURES" --recipe-path recipe.json
 
 # Build application
+# Platform-specific RUSTFLAGS: amd64 uses x86-64-v3 (Haswell+) with pclmulqdq for rocksdb
+#
+# TARGETPLATFORM is set by BuildKit: https://docs.docker.com/reference/dockerfile#automatic-platform-args-in-the-global-scope
+ARG TARGETPLATFORM
 COPY --exclude=dist . .
-RUN cargo build --profile $BUILD_PROFILE --features "$FEATURES" --locked --bin reth
+RUN if [ -n "$RUSTFLAGS" ]; then \
+        export RUSTFLAGS="$RUSTFLAGS"; \
+    elif [ "$TARGETPLATFORM" = "linux/amd64" ]; then \
+        export RUSTFLAGS="-C target-cpu=x86-64-v3 -C target-feature=+pclmulqdq"; \
+    fi && \
+    cargo build --profile $BUILD_PROFILE --features "$FEATURES" --locked --bin reth
 
 # ARG is not resolved in COPY so we have to hack around it by copying the
 # binary to a temporary location