diff --git a/crates/cli/commands/src/node.rs b/crates/cli/commands/src/node.rs
index cba857a3a84..a04744e7c25 100644
--- a/crates/cli/commands/src/node.rs
+++ b/crates/cli/commands/src/node.rs
@@ -10,7 +10,8 @@ use reth_node_builder::NodeBuilder;
 use reth_node_core::{
     args::{
         DatabaseArgs, DatadirArgs, DebugArgs, DevArgs, EngineArgs, EraArgs, MetricArgs,
-        NetworkArgs, PayloadBuilderArgs, PruningArgs, RpcServerArgs, StaticFilesArgs, TxPoolArgs,
+        NetworkArgs, PayloadBuilderArgs, PruningArgs, RocksDbArgs, RpcServerArgs, StaticFilesArgs,
+        TxPoolArgs,
     },
     node_config::NodeConfig,
     version,
@@ -102,6 +103,10 @@ pub struct NodeCommand<C: ChainSpecParser, Ext: clap::Args + fmt::Debug = NoArgs
     #[command(flatten)]
     pub pruning: PruningArgs,
 
+    /// All `RocksDB` table routing arguments
+    #[command(flatten)]
+    pub rocksdb: RocksDbArgs,
+
     /// Engine cli arguments
     #[command(flatten, next_help_heading = "Engine")]
     pub engine: EngineArgs,
@@ -166,6 +171,7 @@ where
             db,
             dev,
             pruning,
+            rocksdb,
             engine,
             era,
             static_files,
@@ -187,6 +193,7 @@ where
             db,
             dev,
             pruning,
+            rocksdb,
             engine,
             era,
             static_files,
diff --git a/crates/node/builder/src/launch/common.rs b/crates/node/builder/src/launch/common.rs
index e351fe96f65..d1205efd35d 100644
--- a/crates/node/builder/src/launch/common.rs
+++ b/crates/node/builder/src/launch/common.rs
@@ -66,9 +66,9 @@ use reth_node_metrics::{
 };
 use reth_provider::{
     providers::{NodeTypesForProvider, ProviderNodeTypes, RocksDBProvider, StaticFileProvider},
-    BlockHashReader, BlockNumReader, DatabaseProviderFactory, ProviderError, ProviderFactory,
-    ProviderResult, RocksDBProviderFactory, StageCheckpointReader, StaticFileProviderBuilder,
-    StaticFileProviderFactory,
+    BlockHashReader, BlockNumReader, DatabaseProviderFactory, MetadataProvider, ProviderError,
+    ProviderFactory, ProviderResult, RocksDBProviderFactory, StageCheckpointReader,
+    StaticFileProviderBuilder, StaticFileProviderFactory,
 };
 use reth_prune::{PruneModes, PrunerBuilder};
 use reth_rpc_builder::config::RethRpcServerConfig;
@@ -676,19 +676,27 @@ where
 
     /// Convenience function to [`Self::init_genesis`]
     pub fn with_genesis(self) -> Result<Self, InitStorageError> {
-        init_genesis_with_settings(
-            self.provider_factory(),
-            self.node_config().static_files.to_settings(),
-        )?;
+        self.init_genesis()?;
         Ok(self)
     }
 
-    /// Write the genesis block and state if it has not already been written
+    /// Write the genesis block and state if it has not already been written.
+    ///
+    /// After initialization, validates that any CLI `RocksDB` overrides match the persisted
+    /// storage settings. These settings are genesis-initialization-only and cannot be changed.
     pub fn init_genesis(&self) -> Result<B256, InitStorageError> {
-        init_genesis_with_settings(
-            self.provider_factory(),
-            self.node_config().static_files.to_settings(),
-        )
+        let base_settings = self.node_config().static_files.to_settings();
+        let (settings, _) = self.node_config().rocksdb.apply_to_settings(base_settings);
+        let hash = init_genesis_with_settings(self.provider_factory(), settings)?;
+
+        // Validate CLI overrides match persisted settings
+        if let Some(persisted) = self.provider_factory().storage_settings()?
+            && let Err(e) = self.node_config().rocksdb.validate_against_persisted(&persisted)
+        {
+            return Err(InitStorageError::RocksDbSettingsMismatch(e.to_string()));
+        }
+
+        Ok(hash)
     }
 
     /// Creates a new `WithMeteredProvider` container and attaches it to the
diff --git a/crates/node/core/src/args/mod.rs b/crates/node/core/src/args/mod.rs
index 9351128570d..b8746478cc2 100644
--- a/crates/node/core/src/args/mod.rs
+++ b/crates/node/core/src/args/mod.rs
@@ -80,5 +80,9 @@ pub use era::{DefaultEraHost, EraArgs, EraSourceArgs};
 mod static_files;
 pub use static_files::{StaticFilesArgs, MINIMAL_BLOCKS_PER_FILE};
 
+/// `RocksDbArgs` for configuring RocksDB table routing.
+mod rocksdb;
+pub use rocksdb::{RocksDbArgs, RocksDbSettingsMismatchError};
+
 mod error;
 pub mod types;
diff --git a/crates/node/core/src/args/rocksdb.rs b/crates/node/core/src/args/rocksdb.rs
new file mode 100644
index 00000000000..672e243876f
--- /dev/null
+++ b/crates/node/core/src/args/rocksdb.rs
@@ -0,0 +1,337 @@
+//! clap [Args](clap::Args) for `RocksDB` table routing configuration
+
+use clap::{ArgAction, Args};
+use reth_storage_api::StorageSettings;
+use std::fmt;
+
+/// Parameters for `RocksDB` table routing configuration.
+///
+/// These flags control which database tables are stored in `RocksDB` instead of MDBX.
+/// All flags are genesis-initialization-only: changing them after genesis requires a re-sync.
+#[derive(Debug, Args, PartialEq, Eq, Default, Clone, Copy)]
+#[command(next_help_heading = "RocksDB")]
+pub struct RocksDbArgs {
+    /// Route tx hash -> number table to `RocksDB` instead of MDBX.
+    #[arg(long = "rocksdb.tx-hash", action = ArgAction::Set)]
+    pub tx_hash: Option<bool>,
+
+    /// Route storages history tables to `RocksDB` instead of MDBX.
+    #[arg(long = "rocksdb.storages-history", action = ArgAction::Set)]
+    pub storages_history: Option<bool>,
+
+    /// Route account history tables to `RocksDB` instead of MDBX.
+    #[arg(long = "rocksdb.account-history", action = ArgAction::Set)]
+    pub account_history: Option<bool>,
+}
+
+impl RocksDbArgs {
+    /// Applies CLI overrides to the given defaults, returning the resulting settings.
+    ///
+    /// If any flag is set to `true`, all `RocksDB` tables are enabled by default, then explicit
+    /// `false` overrides are applied. This grouped behavior ensures users get the full `RocksDB`
+    /// benefit without needing to specify all flags.
+    ///
+    /// Returns `(settings, grouped_enabled)` where `grouped_enabled` is true if the grouped
+    /// behavior was triggered (any flag was true, enabling all tables).
+    pub fn apply_to_settings(&self, mut settings: StorageSettings) -> (StorageSettings, bool) {
+        let any_true = self.tx_hash == Some(true) ||
+            self.storages_history == Some(true) ||
+            self.account_history == Some(true);
+
+        if any_true {
+            settings.transaction_hash_numbers_in_rocksdb = true;
+            settings.storages_history_in_rocksdb = true;
+            settings.account_history_in_rocksdb = true;
+        }
+
+        if let Some(value) = self.tx_hash {
+            settings.transaction_hash_numbers_in_rocksdb = value;
+        }
+        if let Some(value) = self.storages_history {
+            settings.storages_history_in_rocksdb = value;
+        }
+        if let Some(value) = self.account_history {
+            settings.account_history_in_rocksdb = value;
+        }
+
+        (settings, any_true)
+    }
+
+    /// Returns true if any `RocksDB` table routing flag was explicitly set.
+    pub const fn has_overrides(&self) -> bool {
+        self.tx_hash.is_some() || self.storages_history.is_some() || self.account_history.is_some()
+    }
+
+    /// Validates that CLI overrides match the persisted storage settings.
+    ///
+    /// This should be called at startup after loading the persisted settings but before
+    /// the pipeline starts. If any CLI override differs from the persisted value,
+    /// returns an error since these are genesis-initialization-only settings.
+    ///
+    /// Returns `Ok(())` if:
+    /// - No CLI overrides are set (all `None`)
+    /// - All CLI overrides match the persisted values
+    ///
+    /// Returns `Err` if any CLI override differs from the persisted value.
+    pub const fn validate_against_persisted(
+        &self,
+        persisted: &StorageSettings,
+    ) -> Result<(), RocksDbSettingsMismatchError> {
+        if let Some(cli_value) = self.tx_hash &&
+            cli_value != persisted.transaction_hash_numbers_in_rocksdb
+        {
+            return Err(RocksDbSettingsMismatchError {
+                flag_name: "--rocksdb.tx-hash",
+                expected: persisted.transaction_hash_numbers_in_rocksdb,
+                got: cli_value,
+            });
+        }
+
+        if let Some(cli_value) = self.storages_history &&
+            cli_value != persisted.storages_history_in_rocksdb
+        {
+            return Err(RocksDbSettingsMismatchError {
+                flag_name: "--rocksdb.storages-history",
+                expected: persisted.storages_history_in_rocksdb,
+                got: cli_value,
+            });
+        }
+
+        if let Some(cli_value) = self.account_history &&
+            cli_value != persisted.account_history_in_rocksdb
+        {
+            return Err(RocksDbSettingsMismatchError {
+                flag_name: "--rocksdb.account-history",
+                expected: persisted.account_history_in_rocksdb,
+                got: cli_value,
+            });
+        }
+
+        Ok(())
+    }
+}
+
+/// Error returned when a CLI `RocksDB` flag differs from the persisted storage settings.
+///
+/// These settings are genesis-initialization-only and cannot be changed after the node
+/// has been initialized.
+#[derive(Debug, Clone, PartialEq, Eq)]
+pub struct RocksDbSettingsMismatchError {
+    /// The CLI flag name that mismatched.
+    pub flag_name: &'static str,
+    /// The expected value (from persisted settings).
+    pub expected: bool,
+    /// The value provided via CLI.
+    pub got: bool,
+}
+
+impl fmt::Display for RocksDbSettingsMismatchError {
+    fn fmt(&self, f: &mut fmt::Formatter<'_>) -> fmt::Result {
+        write!(
+            f,
+            "`{}` differs from initialized layout (expected {}, got {}). \
+             This setting is genesis-only; re-sync required (remove datadir or use a new datadir).",
+            self.flag_name, self.expected, self.got
+        )
+    }
+}
+
+impl std::error::Error for RocksDbSettingsMismatchError {}
+
+#[cfg(test)]
+mod tests {
+    use super::*;
+    use clap::Parser;
+
+    #[derive(Parser)]
+    struct CommandParser<T: Args> {
+        #[command(flatten)]
+        args: T,
+    }
+
+    #[test]
+    fn test_default_rocksdb_args() {
+        let args = CommandParser::<RocksDbArgs>::parse_from(["reth"]).args;
+        assert_eq!(args, RocksDbArgs::default());
+    }
+
+    #[test]
+    fn test_parse_all_flags() {
+        let args = CommandParser::<RocksDbArgs>::parse_from([
+            "reth",
+            "--rocksdb.tx-hash=true",
+            "--rocksdb.storages-history=false",
+            "--rocksdb.account-history=true",
+        ])
+        .args;
+        assert_eq!(args.tx_hash, Some(true));
+        assert_eq!(args.storages_history, Some(false));
+        assert_eq!(args.account_history, Some(true));
+    }
+
+    #[test]
+    fn test_apply_to_settings_grouped_enable() {
+        let args =
+            RocksDbArgs { tx_hash: Some(true), storages_history: None, account_history: None };
+        let (result, grouped) = args.apply_to_settings(StorageSettings::legacy());
+
+        assert!(grouped, "should trigger grouped behavior when any flag is true");
+        assert!(result.transaction_hash_numbers_in_rocksdb);
+        assert!(result.storages_history_in_rocksdb, "grouped: all tables enabled");
+        assert!(result.account_history_in_rocksdb, "grouped: all tables enabled");
+    }
+
+    #[test]
+    fn test_apply_to_settings_explicit_disable() {
+        let args = RocksDbArgs {
+            tx_hash: Some(true),
+            storages_history: Some(false),
+            account_history: None,
+        };
+        let (result, grouped) = args.apply_to_settings(StorageSettings::legacy());
+
+        assert!(grouped);
+        assert!(result.transaction_hash_numbers_in_rocksdb);
+        assert!(!result.storages_history_in_rocksdb, "explicit false overrides grouped enable");
+        assert!(result.account_history_in_rocksdb);
+    }
+
+    #[test]
+    fn test_apply_to_settings_no_grouped_when_all_none() {
+        let args = RocksDbArgs::default();
+        let (result, grouped) = args.apply_to_settings(StorageSettings::legacy());
+
+        assert!(!grouped, "no grouped behavior when no flags set");
+        assert!(!result.transaction_hash_numbers_in_rocksdb);
+        assert!(!result.storages_history_in_rocksdb);
+        assert!(!result.account_history_in_rocksdb);
+    }
+
+    #[test]
+    fn test_apply_to_settings_all_explicit_false() {
+        let args = RocksDbArgs {
+            tx_hash: Some(false),
+            storages_history: Some(false),
+            account_history: Some(false),
+        };
+        let (result, grouped) = args.apply_to_settings(StorageSettings::legacy());
+
+        assert!(!grouped, "no grouped when all explicit false");
+        assert!(!result.transaction_hash_numbers_in_rocksdb);
+        assert!(!result.storages_history_in_rocksdb);
+        assert!(!result.account_history_in_rocksdb);
+    }
+
+    #[test]
+    fn test_apply_to_settings_preserves_non_rocksdb_fields() {
+        let base = StorageSettings::legacy().with_receipts_in_static_files(true);
+        let args =
+            RocksDbArgs { tx_hash: Some(true), storages_history: None, account_history: None };
+        let (result, _) = args.apply_to_settings(base);
+
+        assert!(result.receipts_in_static_files, "non-rocksdb settings preserved");
+    }
+
+    #[test]
+    fn test_validate_no_overrides_passes() {
+        let args = RocksDbArgs::default();
+        let persisted = StorageSettings::legacy().with_transaction_hash_numbers_in_rocksdb(true);
+        assert!(args.validate_against_persisted(&persisted).is_ok());
+    }
+
+    #[test]
+    fn test_validate_matching_overrides_passes() {
+        let args = RocksDbArgs {
+            tx_hash: Some(true),
+            storages_history: Some(false),
+            account_history: Some(false),
+        };
+        let persisted = StorageSettings::legacy().with_transaction_hash_numbers_in_rocksdb(true);
+        assert!(args.validate_against_persisted(&persisted).is_ok());
+    }
+
+    #[test]
+    fn test_validate_mismatched_tx_hash_fails() {
+        let args = RocksDbArgs { tx_hash: Some(true), ..Default::default() };
+        let persisted = StorageSettings::legacy();
+
+        let err = args.validate_against_persisted(&persisted).unwrap_err();
+        assert_eq!(err.flag_name, "--rocksdb.tx-hash");
+        assert!(!err.expected);
+        assert!(err.got);
+        assert!(err.to_string().contains("--rocksdb.tx-hash"));
+        assert!(err.to_string().contains("genesis-only"));
+    }
+
+    #[test]
+    fn test_validate_mismatched_storages_history_fails() {
+        let args = RocksDbArgs { storages_history: Some(false), ..Default::default() };
+        let persisted = StorageSettings::legacy().with_storages_history_in_rocksdb(true);
+
+        let err = args.validate_against_persisted(&persisted).unwrap_err();
+        assert_eq!(err.flag_name, "--rocksdb.storages-history");
+        assert!(err.expected);
+        assert!(!err.got);
+    }
+
+    #[test]
+    fn test_validate_mismatched_account_history_fails() {
+        let args = RocksDbArgs { account_history: Some(true), ..Default::default() };
+        let persisted = StorageSettings::legacy();
+
+        let err = args.validate_against_persisted(&persisted).unwrap_err();
+        assert_eq!(err.flag_name, "--rocksdb.account-history");
+        assert!(!err.expected);
+        assert!(err.got);
+    }
+
+    #[test]
+    fn test_error_message_format() {
+        let err = RocksDbSettingsMismatchError {
+            flag_name: "--rocksdb.tx-hash",
+            expected: false,
+            got: true,
+        };
+        let msg = err.to_string();
+        assert!(msg.contains("--rocksdb.tx-hash"));
+        assert!(msg.contains("expected false"));
+        assert!(msg.contains("got true"));
+        assert!(msg.contains("genesis-only"));
+        assert!(msg.contains("re-sync required"));
+    }
+
+    #[test]
+    fn test_validate_matching_false_overrides_passes() {
+        // Test that explicitly setting false matches persisted false
+        let args = RocksDbArgs {
+            tx_hash: Some(false),
+            storages_history: Some(false),
+            account_history: Some(false),
+        };
+        let persisted = StorageSettings::legacy(); // All rocksdb flags are false
+        assert!(args.validate_against_persisted(&persisted).is_ok());
+    }
+
+    #[test]
+    fn test_validate_multiple_mismatches_returns_first() {
+        // When multiple fields mismatch, the first one (tx_hash) is reported
+        let args = RocksDbArgs {
+            tx_hash: Some(true),
+            storages_history: Some(true),
+            account_history: Some(true),
+        };
+        let persisted = StorageSettings::legacy(); // All false
+
+        let err = args.validate_against_persisted(&persisted).unwrap_err();
+        // Should report the first mismatch (tx_hash is checked first)
+        assert_eq!(err.flag_name, "--rocksdb.tx-hash");
+    }
+
+    #[test]
+    fn test_validate_partial_override_with_match() {
+        // Only one CLI override set, and it matches
+        let args = RocksDbArgs { storages_history: Some(true), ..Default::default() };
+        let persisted = StorageSettings::legacy().with_storages_history_in_rocksdb(true);
+        assert!(args.validate_against_persisted(&persisted).is_ok());
+    }
+}
diff --git a/crates/node/core/src/node_config.rs b/crates/node/core/src/node_config.rs
index 1d5b1700cbe..dda5e1aac04 100644
--- a/crates/node/core/src/node_config.rs
+++ b/crates/node/core/src/node_config.rs
@@ -3,7 +3,7 @@
 use crate::{
     args::{
         DatabaseArgs, DatadirArgs, DebugArgs, DevArgs, EngineArgs, NetworkArgs, PayloadBuilderArgs,
-        PruningArgs, RpcServerArgs, StaticFilesArgs, TxPoolArgs,
+        PruningArgs, RocksDbArgs, RpcServerArgs, StaticFilesArgs, TxPoolArgs,
     },
     dirs::{ChainPath, DataDirPath},
     utils::get_single_header,
@@ -150,6 +150,9 @@ pub struct NodeConfig<ChainSpec> {
 
     /// All static files related arguments
     pub static_files: StaticFilesArgs,
+
+    /// All `RocksDB` table routing arguments
+    pub rocksdb: RocksDbArgs,
 }
 
 impl NodeConfig<ChainSpec> {
@@ -181,6 +184,7 @@ impl<ChainSpec> NodeConfig<ChainSpec> {
             engine: EngineArgs::default(),
             era: EraArgs::default(),
             static_files: StaticFilesArgs::default(),
+            rocksdb: RocksDbArgs::default(),
         }
     }
 
@@ -255,6 +259,7 @@ impl<ChainSpec> NodeConfig<ChainSpec> {
             engine,
             era,
             static_files,
+            rocksdb,
             ..
         } = self;
         NodeConfig {
@@ -274,6 +279,7 @@ impl<ChainSpec> NodeConfig<ChainSpec> {
             engine,
             era,
             static_files,
+            rocksdb,
         }
     }
 
@@ -544,6 +550,7 @@ impl<ChainSpec> NodeConfig<ChainSpec> {
             engine: self.engine,
             era: self.era,
             static_files: self.static_files,
+            rocksdb: self.rocksdb,
         }
     }
 
@@ -585,6 +592,7 @@ impl<ChainSpec> Clone for NodeConfig<ChainSpec> {
             engine: self.engine.clone(),
             era: self.era.clone(),
             static_files: self.static_files,
+            rocksdb: self.rocksdb,
         }
     }
 }
diff --git a/crates/storage/db-common/src/init.rs b/crates/storage/db-common/src/init.rs
index c82025970b7..740c2eab0ec 100644
--- a/crates/storage/db-common/src/init.rs
+++ b/crates/storage/db-common/src/init.rs
@@ -75,6 +75,9 @@ pub enum InitStorageError {
     /// State root doesn't match the expected one.
     #[error("state root mismatch: {_0}")]
     StateRootMismatch(GotExpected<B256>),
+    /// `RocksDB` CLI flag differs from persisted storage settings.
+    #[error("{_0}")]
+    RocksDbSettingsMismatch(String),
 }
 
 impl From<DatabaseError> for InitStorageError {
diff --git a/docs/vocs/docs/pages/cli/op-reth/node.mdx b/docs/vocs/docs/pages/cli/op-reth/node.mdx
index f245315040d..2a701811f0e 100644
--- a/docs/vocs/docs/pages/cli/op-reth/node.mdx
+++ b/docs/vocs/docs/pages/cli/op-reth/node.mdx
@@ -897,6 +897,28 @@ Pruning:
       --prune.bodies.before <BLOCK_NUMBER>
           Prune storage history before the specified block number. The specified block number is not pruned
 
+RocksDB:
+      --rocksdb.tx-hash <TX_HASH>
+          Route tx hash -> number table to `RocksDB` instead of MDBX.
+
+          Note: genesis-initialization-only, changing later requires re-sync.
+
+          [possible values: true, false]
+
+      --rocksdb.storages-history <STORAGES_HISTORY>
+          Route storages history tables to `RocksDB` instead of MDBX.
+
+          Note: genesis-initialization-only, changing later requires re-sync.
+
+          [possible values: true, false]
+
+      --rocksdb.account-history <ACCOUNT_HISTORY>
+          Route account history tables to `RocksDB` instead of MDBX.
+
+          Note: genesis-initialization-only, changing later requires re-sync.
+
+          [possible values: true, false]
+
 Engine:
       --engine.persistence-threshold <PERSISTENCE_THRESHOLD>
           Configure persistence threshold for the engine. This determines how many canonical blocks must be in-memory, ahead of the last persisted block, before flushing canonical blocks to disk again.
diff --git a/docs/vocs/docs/pages/cli/reth/node.mdx b/docs/vocs/docs/pages/cli/reth/node.mdx
index c052076fc89..7d7da147933 100644
--- a/docs/vocs/docs/pages/cli/reth/node.mdx
+++ b/docs/vocs/docs/pages/cli/reth/node.mdx
@@ -897,6 +897,28 @@ Pruning:
       --prune.bodies.before <BLOCK_NUMBER>
           Prune storage history before the specified block number. The specified block number is not pruned
 
+RocksDB:
+      --rocksdb.tx-hash <TX_HASH>
+          Route tx hash -> number table to `RocksDB` instead of MDBX.
+
+          Note: genesis-initialization-only, changing later requires re-sync.
+
+          [possible values: true, false]
+
+      --rocksdb.storages-history <STORAGES_HISTORY>
+          Route storages history tables to `RocksDB` instead of MDBX.
+
+          Note: genesis-initialization-only, changing later requires re-sync.
+
+          [possible values: true, false]
+
+      --rocksdb.account-history <ACCOUNT_HISTORY>
+          Route account history tables to `RocksDB` instead of MDBX.
+
+          Note: genesis-initialization-only, changing later requires re-sync.
+
+          [possible values: true, false]
+
 Engine:
       --engine.persistence-threshold <PERSISTENCE_THRESHOLD>
           Configure persistence threshold for the engine. This determines how many canonical blocks must be in-memory, ahead of the last persisted block, before flushing canonical blocks to disk again.