diff --git a/nx.json b/nx.json
index f53473cfc7..11f689eae3 100644
--- a/nx.json
+++ b/nx.json
@@ -40,7 +40,7 @@
             "outputs": ["{projectRoot}/lib/css"]
         },
         "dev": {
-            "dependsOn": ["^dev"]
+            "dependsOn": ["^compile"]
         },
         "compile:cjs": {
             "dependsOn": ["^compile:cjs"],
@@ -54,11 +54,14 @@
             "dependsOn": ["^dist:bundle"],
             "outputs": ["{projectRoot}/dist"]
         },
+        "test": {
+            "dependsOn": ["^compile"]
+        },
         "test:karma": {
-            "dependsOn": ["^test:karma"]
+            "dependsOn": []
         },
         "test:karma:debug": {
-            "dependsOn": ["^test:karma:debug"]
+            "dependsOn": []
         },
         "bundle": {
             "dependsOn": ["^bundle"],
diff --git a/package.json b/package.json
index 5ed662e0c6..2a8ea530fd 100644
--- a/package.json
+++ b/package.json
@@ -35,7 +35,7 @@
         "verify": "npm-run-all -s compile dist:libs dist:apps -p test lint format-check"
     },
     "dependencies": {
-        "@types/chai": "~4.3.4",
+        "@types/chai": "~4.3.5",
         "@types/enzyme": "~3.10.12",
         "@types/enzyme-adapter-react-16": "~1.0.6",
         "@types/mocha": "~10.0.1",
diff --git a/packages/core/src/components/overlay/overlay.tsx b/packages/core/src/components/overlay/overlay.tsx
index d1c9c5670f..d6dc3bc20f 100644
--- a/packages/core/src/components/overlay/overlay.tsx
+++ b/packages/core/src/components/overlay/overlay.tsx
@@ -105,6 +105,15 @@ export interface OverlayableProps extends OverlayLifecycleProps {
      */
     portalContainer?: HTMLElement;
 
+    /**
+     * A list of DOM events which should be stopped from propagating through the Portal.
+     * This prop is ignored if `usePortal` is `false`.
+     *
+     * @see https://legacy.reactjs.org/docs/portals.html#event-bubbling-through-portals
+     * @see https://github.com/palantir/blueprint/issues/6124
+     */
+    portalStopPropagationEvents?: Array<keyof HTMLElementEventMap>;
+
     /**
      * A callback that is invoked when user interaction causes the overlay to close, such as
      * clicking on the overlay or pressing the `esc` key (if enabled).
@@ -301,7 +310,11 @@ export class Overlay extends AbstractPureComponent<OverlayProps, OverlayState> {
         );
         if (usePortal) {
             return (
-                <Portal className={this.props.portalClassName} container={this.props.portalContainer}>
+                <Portal
+                    className={this.props.portalClassName}
+                    container={this.props.portalContainer}
+                    stopPropagationEvents={this.props.portalStopPropagationEvents}
+                >
                     {transitionGroup}
                 </Portal>
             );
diff --git a/packages/core/src/components/portal/portal.tsx b/packages/core/src/components/portal/portal.tsx
index 74776f8cf8..fe29b265af 100644
--- a/packages/core/src/components/portal/portal.tsx
+++ b/packages/core/src/components/portal/portal.tsx
@@ -38,6 +38,14 @@ export interface PortalProps extends Props {
      * @default document.body
      */
     container?: HTMLElement;
+
+    /**
+     * A list of DOM events which should be stopped from propagating through this portal element.
+     *
+     * @see https://legacy.reactjs.org/docs/portals.html#event-bubbling-through-portals
+     * @see https://github.com/palantir/blueprint/issues/6124
+     */
+    stopPropagationEvents?: Array<keyof HTMLElementEventMap>;
 }
 
 export interface PortalLegacyContext {
@@ -78,6 +86,7 @@ export function Portal(props: PortalProps, legacyContext: PortalLegacyContext =
         container.classList.add(Classes.PORTAL);
         maybeAddClass(container.classList, props.className); // directly added to this portal element
         maybeAddClass(container.classList, context.portalClassName); // added via PortalProvider context
+        addStopPropagationListeners(container, props.stopPropagationEvents);
 
         // TODO: remove legacy context support in Blueprint v6.0
         const { blueprintPortalClassName } = legacyContext;
@@ -100,6 +109,7 @@ export function Portal(props: PortalProps, legacyContext: PortalLegacyContext =
         setHasMounted(true);
 
         return () => {
+            removeStopPropagationListeners(newPortalElement, props.stopPropagationEvents);
             newPortalElement.remove();
             setHasMounted(false);
             setPortalElement(undefined);
@@ -122,6 +132,15 @@ export function Portal(props: PortalProps, legacyContext: PortalLegacyContext =
         }
     }, [props.className]);
 
+    // update stopPropagation listeners when props change
+    const prevStopPropagationEvents = usePrevious(props.stopPropagationEvents);
+    React.useEffect(() => {
+        if (portalElement != null) {
+            removeStopPropagationListeners(portalElement, prevStopPropagationEvents);
+            addStopPropagationListeners(portalElement, props.stopPropagationEvents);
+        }
+    }, [props.stopPropagationEvents]);
+
     // Only render `children` once this component has mounted in a browser environment, so they are
     // immediately attached to the DOM tree and can do DOM things like measuring or `autoFocus`.
     // See long comment on componentDidMount in https://reactjs.org/docs/portals.html#event-bubbling-through-portals
@@ -149,3 +168,15 @@ function maybeAddClass(classList: DOMTokenList, className?: string) {
         classList.add(...className.split(" "));
     }
 }
+
+function addStopPropagationListeners(portalElement: HTMLElement, eventNames?: Array<keyof HTMLElementEventMap>) {
+    eventNames?.forEach(event => portalElement.addEventListener(event, handleStopProgation));
+}
+
+function removeStopPropagationListeners(portalElement: HTMLElement, events?: Array<keyof HTMLElementEventMap>) {
+    events?.forEach(event => portalElement.removeEventListener(event, handleStopProgation));
+}
+
+function handleStopProgation(e: Event) {
+    e.stopPropagation();
+}
diff --git a/yarn.lock b/yarn.lock
index c81ec90923..e34d1eeced 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -1454,10 +1454,10 @@
   resolved "https://registry.yarnpkg.com/@types/btoa-lite/-/btoa-lite-1.0.0.tgz#e190a5a548e0b348adb0df9ac7fa5f1151c7cca4"
   integrity sha512-wJsiX1tosQ+J5+bY5LrSahHxr2wT+uME5UDwdN1kg4frt40euqA+wzECkmq4t5QbveHiJepfdThgQrPw6KiSlg==
 
-"@types/chai@~4.3.4":
-  version "4.3.4"
-  resolved "https://registry.yarnpkg.com/@types/chai/-/chai-4.3.4.tgz#e913e8175db8307d78b4e8fa690408ba6b65dee4"
-  integrity sha512-KnRanxnpfpjUTqTCXslZSEdLfXExwgNxYPdiO2WGUj8+HDjFi8R3k5RVKPeSCzLjCcshCAtVO2QBbVuAV4kTnw==
+"@types/chai@~4.3.5":
+  version "4.3.5"
+  resolved "https://registry.yarnpkg.com/@types/chai/-/chai-4.3.5.tgz#ae69bcbb1bebb68c4ac0b11e9d8ed04526b3562b"
+  integrity sha512-mEo1sAde+UCE6b2hxn332f1g1E8WfYRu6p5SvTKr2ZKC1f7gFJXk4h5PyGP9Dt6gCaG8y8XhwnXWC6Iy2cmBng==
 
 "@types/cheerio@*":
   version "0.22.23"