diff --git a/crates/oxc_transformer/src/plugins/replace_global_defines.rs b/crates/oxc_transformer/src/plugins/replace_global_defines.rs
index 6f3293f8acd4f..bb41d4cb2420c 100644
--- a/crates/oxc_transformer/src/plugins/replace_global_defines.rs
+++ b/crates/oxc_transformer/src/plugins/replace_global_defines.rs
@@ -1,7 +1,7 @@
 use std::{cmp::Ordering, sync::Arc};
 
 use lazy_static::lazy_static;
-use oxc_allocator::Allocator;
+use oxc_allocator::{Address, Allocator, GetAddress};
 use oxc_ast::ast::*;
 use oxc_diagnostics::OxcDiagnostic;
 use oxc_parser::Parser;
@@ -220,12 +220,31 @@ pub struct ReplaceGlobalDefinesReturn {
 pub struct ReplaceGlobalDefines<'a> {
     allocator: &'a Allocator,
     config: ReplaceGlobalDefinesConfig,
+    /// Since `Traverse` did not provide a way to skipping visiting sub tree of the AstNode,
+    /// Use `Option<Address>` to lock the current node when it is `Some`.
+    /// during visiting sub tree, the `Lock` will always be `Some`, and we can early return, this
+    /// could acheieve same effect as skipping visiting sub tree.
+    /// When `exit` the node, reset the `Lock` to `None` to make sure not affect other
+    /// transformation.
+    ast_node_lock: Option<Address>,
 }
 
 impl<'a> Traverse<'a> for ReplaceGlobalDefines<'a> {
     fn enter_expression(&mut self, expr: &mut Expression<'a>, ctx: &mut TraverseCtx<'a>) {
-        self.replace_identifier_defines(expr, ctx);
-        self.replace_dot_defines(expr, ctx);
+        if self.ast_node_lock.is_some() {
+            return;
+        }
+        let is_replaced =
+            self.replace_identifier_defines(expr, ctx) || self.replace_dot_defines(expr, ctx);
+        if is_replaced {
+            self.ast_node_lock = Some(expr.address());
+        }
+    }
+
+    fn exit_expression(&mut self, node: &mut Expression<'a>, _ctx: &mut TraverseCtx<'a>) {
+        if self.ast_node_lock == Some(node.address()) {
+            self.ast_node_lock = None;
+        }
     }
 
     fn enter_assignment_expression(
@@ -233,13 +252,30 @@ impl<'a> Traverse<'a> for ReplaceGlobalDefines<'a> {
         node: &mut AssignmentExpression<'a>,
         ctx: &mut TraverseCtx<'a>,
     ) {
-        self.replace_define_with_assignment_expr(node, ctx);
+        if self.ast_node_lock.is_some() {
+            return;
+        }
+        if self.replace_define_with_assignment_expr(node, ctx) {
+            // `AssignmentExpression` is stored in a `Box`, so we can use `from_ptr` to get
+            // the stable address
+            self.ast_node_lock = Some(Address::from_ptr(node));
+        }
+    }
+
+    fn exit_assignment_expression(
+        &mut self,
+        node: &mut AssignmentExpression<'a>,
+        _: &mut TraverseCtx<'a>,
+    ) {
+        if self.ast_node_lock == Some(Address::from_ptr(node)) {
+            self.ast_node_lock = None;
+        }
     }
 }
 
 impl<'a> ReplaceGlobalDefines<'a> {
     pub fn new(allocator: &'a Allocator, config: ReplaceGlobalDefinesConfig) -> Self {
-        Self { allocator, config }
+        Self { allocator, config, ast_node_lock: None }
     }
 
     pub fn build(
@@ -260,11 +296,16 @@ impl<'a> ReplaceGlobalDefines<'a> {
         Parser::new(self.allocator, source_text, SourceType::default()).parse_expression().unwrap()
     }
 
-    fn replace_identifier_defines(&self, expr: &mut Expression<'a>, ctx: &mut TraverseCtx<'a>) {
+    fn replace_identifier_defines(
+        &self,
+        expr: &mut Expression<'a>,
+        ctx: &mut TraverseCtx<'a>,
+    ) -> bool {
         match expr {
             Expression::Identifier(ident) => {
                 if let Some(new_expr) = self.replace_identifier_define_impl(ident, ctx) {
                     *expr = new_expr;
+                    return true;
                 }
             }
             Expression::ThisExpression(_)
@@ -275,12 +316,14 @@ impl<'a> ReplaceGlobalDefines<'a> {
                     if key.as_str() == "this" {
                         let value = self.parse_value(value);
                         *expr = value;
-                        break;
+
+                        return true;
                     }
                 }
             }
             _ => {}
         }
+        false
     }
 
     fn replace_identifier_define_impl(
@@ -305,7 +348,7 @@ impl<'a> ReplaceGlobalDefines<'a> {
         &mut self,
         node: &mut AssignmentExpression<'a>,
         ctx: &mut TraverseCtx<'a>,
-    ) {
+    ) -> bool {
         let new_left = node
             .left
             .as_simple_assignment_target_mut()
@@ -324,10 +367,16 @@ impl<'a> ReplaceGlobalDefines<'a> {
             .and_then(assignment_target_from_expr);
         if let Some(new_left) = new_left {
             node.left = new_left;
+            return true;
         }
+        false
     }
 
-    fn replace_dot_defines(&mut self, expr: &mut Expression<'a>, ctx: &mut TraverseCtx<'a>) {
+    fn replace_dot_defines(
+        &mut self,
+        expr: &mut Expression<'a>,
+        ctx: &mut TraverseCtx<'a>,
+    ) -> bool {
         match expr {
             Expression::ChainExpression(chain) => {
                 let Some(new_expr) =
@@ -341,18 +390,21 @@ impl<'a> ReplaceGlobalDefines<'a> {
                         MemberExpression::PrivateFieldExpression(_) => None,
                     })
                 else {
-                    return;
+                    return false;
                 };
                 *expr = new_expr;
+                return true;
             }
             Expression::StaticMemberExpression(member) => {
                 if let Some(new_expr) = self.replace_dot_static_member_expr(ctx, member) {
                     *expr = new_expr;
+                    return true;
                 }
             }
             Expression::ComputedMemberExpression(member) => {
                 if let Some(new_expr) = self.replace_dot_computed_member_expr(ctx, member) {
                     *expr = new_expr;
+                    return true;
                 }
             }
             Expression::MetaProperty(meta_property) => {
@@ -361,11 +413,13 @@ impl<'a> ReplaceGlobalDefines<'a> {
                     {
                         let value = self.parse_value(replacement);
                         *expr = value;
+                        return true;
                     }
                 }
             }
             _ => {}
         }
+        false
     }
 
     fn replace_dot_computed_member_expr(
diff --git a/crates/oxc_transformer/tests/integrations/plugins/replace_global_defines.rs b/crates/oxc_transformer/tests/integrations/plugins/replace_global_defines.rs
index f7ddd2c783088..1dd021a0bb897 100644
--- a/crates/oxc_transformer/tests/integrations/plugins/replace_global_defines.rs
+++ b/crates/oxc_transformer/tests/integrations/plugins/replace_global_defines.rs
@@ -59,7 +59,6 @@ fn dot() {
     test("process['env'].NODE_ENV", "production", config.clone());
 }
 
-#[ignore]
 #[test]
 fn dot_with_overlap() {
     let config = ReplaceGlobalDefinesConfig::new(&[
@@ -68,7 +67,12 @@ fn dot_with_overlap() {
     ])
     .unwrap();
     test("import.meta.env", "__foo__", config.clone());
-    test("import.meta.env.NODE_ENV", "import.meta.env.NODE_ENV", config.clone());
+    test("import.meta.env.FOO", "import.meta.env.FOO", config.clone());
+    test("import.meta.env.NODE_ENV", "__foo__.NODE_ENV", config.clone());
+
+    test("import.meta.env = 0", "__foo__ = 0", config.clone());
+    test("import.meta.env.NODE_ENV = 0", "__foo__.NODE_ENV = 0", config.clone());
+    test("import.meta.env.FOO = 0", "import.meta.env.FOO = 0", config.clone());
 }
 
 #[test]