diff --git a/ci-operator/config/openshift/release/openshift-release-main__nightly-4.22.yaml b/ci-operator/config/openshift/release/openshift-release-main__nightly-4.22.yaml
index b35415e1bc986..1689d0e4d221a 100644
--- a/ci-operator/config/openshift/release/openshift-release-main__nightly-4.22.yaml
+++ b/ci-operator/config/openshift/release/openshift-release-main__nightly-4.22.yaml
@@ -1976,19 +1976,6 @@ tests:
         MASTER_VCPU=8
       TEST_SUITE: openshift/conformance/parallel
     workflow: agent-e2e-generic-conformance
-- as: e2e-agent-compact-iso-no-registry-techpreview
-  capabilities:
-  - intranet
-  cron: 0 */12 * * *
-  steps:
-    cluster_profile: equinix-ocp-metal
-    env:
-      DEVSCRIPTS_CONFIG: |
-        AGENT_E2E_TEST_SCENARIO=COMPACT_IPV4
-        AGENT_E2E_TEST_BOOT_MODE=ISO_NO_REGISTRY
-        AGENT_CLEANUP_ISO_BUILDER_CACHE_LOCAL_DEV=true
-        FEATURE_SET=TechPreviewNoUpgrade
-    workflow: agent-e2e-generic-conformance-iso-no-registry
 - as: e2e-agent-single-node-ipv6-conformance
   capabilities:
   - intranet
diff --git a/ci-operator/config/openshift/release/openshift-release-main__nightly-5.0.yaml b/ci-operator/config/openshift/release/openshift-release-main__nightly-5.0.yaml
index 4555317fffaab..54847247d7e6e 100644
--- a/ci-operator/config/openshift/release/openshift-release-main__nightly-5.0.yaml
+++ b/ci-operator/config/openshift/release/openshift-release-main__nightly-5.0.yaml
@@ -2159,6 +2159,19 @@ tests:
         AGENT_CLEANUP_ISO_BUILDER_CACHE_LOCAL_DEV=true
         FEATURE_SET=TechPreviewNoUpgrade
     workflow: agent-e2e-generic-conformance-iso-no-registry
+- as: e2e-agent-ha5-dualstack-iso-no-registry-techpreview
+  capabilities:
+  - intranet
+  cron: 0 */8 * * *
+  steps:
+    cluster_profile: equinix-ocp-metal
+    env:
+      DEVSCRIPTS_CONFIG: |
+        AGENT_E2E_TEST_SCENARIO=5CONTROL_IPV4V6
+        AGENT_E2E_TEST_BOOT_MODE=ISO_NO_REGISTRY
+        AGENT_CLEANUP_ISO_BUILDER_CACHE_LOCAL_DEV=true
+        FEATURE_SET=TechPreviewNoUpgrade
+    workflow: agent-e2e-generic-conformance-iso-no-registry
 - as: e2e-agent-single-node-ipv6-conformance
   capabilities:
   - intranet
diff --git a/ci-operator/jobs/openshift/release/openshift-release-main-periodics.yaml b/ci-operator/jobs/openshift/release/openshift-release-main-periodics.yaml
index 340320964541b..10c35ced6eabc 100644
--- a/ci-operator/jobs/openshift/release/openshift-release-main-periodics.yaml
+++ b/ci-operator/jobs/openshift/release/openshift-release-main-periodics.yaml
@@ -209742,91 +209742,6 @@ periodics:
     - name: result-aggregator
       secret:
         secretName: result-aggregator
-- agent: kubernetes
-  cluster: build10
-  cron: 0 */12 * * *
-  decorate: true
-  decoration_config:
-    skip_cloning: true
-  extra_refs:
-  - base_ref: main
-    org: openshift
-    repo: release
-  labels:
-    capability/intranet: intranet
-    ci-operator.openshift.io/cloud: equinix-ocp-metal
-    ci-operator.openshift.io/cloud-cluster-profile: equinix-ocp-metal
-    ci-operator.openshift.io/variant: nightly-4.22
-    ci.openshift.io/generator: prowgen
-    ci.openshift.io/no-builds: "true"
-    job-release: "4.22"
-    pj-rehearse.openshift.io/can-be-rehearsed: "true"
-  name: periodic-ci-openshift-release-main-nightly-4.22-e2e-agent-compact-iso-no-registry-techpreview
-  spec:
-    containers:
-    - args:
-      - --gcs-upload-secret=/secrets/gcs/service-account.json
-      - --image-import-pull-secret=/etc/pull-secret/.dockerconfigjson
-      - --lease-server-credentials-file=/etc/boskos/credentials
-      - --report-credentials-file=/etc/report/credentials
-      - --secret-dir=/secrets/ci-pull-credentials
-      - --target=e2e-agent-compact-iso-no-registry-techpreview
-      - --variant=nightly-4.22
-      command:
-      - ci-operator
-      env:
-      - name: HTTP_SERVER_IP
-        valueFrom:
-          fieldRef:
-            fieldPath: status.podIP
-      image: quay-proxy.ci.openshift.org/openshift/ci:ci_ci-operator_latest
-      imagePullPolicy: Always
-      name: ""
-      ports:
-      - containerPort: 8080
-        name: http
-      resources:
-        requests:
-          cpu: 10m
-      volumeMounts:
-      - mountPath: /etc/boskos
-        name: boskos
-        readOnly: true
-      - mountPath: /secrets/ci-pull-credentials
-        name: ci-pull-credentials
-        readOnly: true
-      - mountPath: /secrets/gcs
-        name: gcs-credentials
-        readOnly: true
-      - mountPath: /secrets/manifest-tool
-        name: manifest-tool-local-pusher
-        readOnly: true
-      - mountPath: /etc/pull-secret
-        name: pull-secret
-        readOnly: true
-      - mountPath: /etc/report
-        name: result-aggregator
-        readOnly: true
-    serviceAccountName: ci-operator
-    volumes:
-    - name: boskos
-      secret:
-        items:
-        - key: credentials
-          path: credentials
-        secretName: boskos-credentials
-    - name: ci-pull-credentials
-      secret:
-        secretName: ci-pull-credentials
-    - name: manifest-tool-local-pusher
-      secret:
-        secretName: manifest-tool-local-pusher
-    - name: pull-secret
-      secret:
-        secretName: registry-pull-credentials
-    - name: result-aggregator
-      secret:
-        secretName: result-aggregator
 - agent: kubernetes
   cluster: build10
   cron: 0 */12 * * *
@@ -268446,7 +268361,7 @@ periodics:
       secret:
         secretName: result-aggregator
 - agent: kubernetes
-  cluster: build10
+  cluster: build06
   cron: 0 */8 * * *
   decorate: true
   decoration_config:
@@ -268701,7 +268616,92 @@ periodics:
       secret:
         secretName: result-aggregator
 - agent: kubernetes
-  cluster: build10
+  cluster: build06
+  cron: 0 */8 * * *
+  decorate: true
+  decoration_config:
+    skip_cloning: true
+  extra_refs:
+  - base_ref: main
+    org: openshift
+    repo: release
+  labels:
+    capability/intranet: intranet
+    ci-operator.openshift.io/cloud: equinix-ocp-metal
+    ci-operator.openshift.io/cloud-cluster-profile: equinix-ocp-metal
+    ci-operator.openshift.io/variant: nightly-5.0
+    ci.openshift.io/generator: prowgen
+    ci.openshift.io/no-builds: "true"
+    job-release: "5.0"
+    pj-rehearse.openshift.io/can-be-rehearsed: "true"
+  name: periodic-ci-openshift-release-main-nightly-5.0-e2e-agent-ha5-dualstack-iso-no-registry-techpreview
+  spec:
+    containers:
+    - args:
+      - --gcs-upload-secret=/secrets/gcs/service-account.json
+      - --image-import-pull-secret=/etc/pull-secret/.dockerconfigjson
+      - --lease-server-credentials-file=/etc/boskos/credentials
+      - --report-credentials-file=/etc/report/credentials
+      - --secret-dir=/secrets/ci-pull-credentials
+      - --target=e2e-agent-ha5-dualstack-iso-no-registry-techpreview
+      - --variant=nightly-5.0
+      command:
+      - ci-operator
+      env:
+      - name: HTTP_SERVER_IP
+        valueFrom:
+          fieldRef:
+            fieldPath: status.podIP
+      image: quay-proxy.ci.openshift.org/openshift/ci:ci_ci-operator_latest
+      imagePullPolicy: Always
+      name: ""
+      ports:
+      - containerPort: 8080
+        name: http
+      resources:
+        requests:
+          cpu: 10m
+      volumeMounts:
+      - mountPath: /etc/boskos
+        name: boskos
+        readOnly: true
+      - mountPath: /secrets/ci-pull-credentials
+        name: ci-pull-credentials
+        readOnly: true
+      - mountPath: /secrets/gcs
+        name: gcs-credentials
+        readOnly: true
+      - mountPath: /secrets/manifest-tool
+        name: manifest-tool-local-pusher
+        readOnly: true
+      - mountPath: /etc/pull-secret
+        name: pull-secret
+        readOnly: true
+      - mountPath: /etc/report
+        name: result-aggregator
+        readOnly: true
+    serviceAccountName: ci-operator
+    volumes:
+    - name: boskos
+      secret:
+        items:
+        - key: credentials
+          path: credentials
+        secretName: boskos-credentials
+    - name: ci-pull-credentials
+      secret:
+        secretName: ci-pull-credentials
+    - name: manifest-tool-local-pusher
+      secret:
+        secretName: manifest-tool-local-pusher
+    - name: pull-secret
+      secret:
+        secretName: registry-pull-credentials
+    - name: result-aggregator
+      secret:
+        secretName: result-aggregator
+- agent: kubernetes
+  cluster: build06
   cron: 11 3 * * *
   decorate: true
   decoration_config: