diff --git a/manifests/0000_50_olm_07-collect-profiles.cronjob.yaml b/manifests/0000_50_olm_07-collect-profiles.cronjob.yaml
index eb878c4786..c6c2fae7eb 100644
--- a/manifests/0000_50_olm_07-collect-profiles.cronjob.yaml
+++ b/manifests/0000_50_olm_07-collect-profiles.cronjob.yaml
@@ -5,6 +5,7 @@ metadata:
     include.release.openshift.io/ibm-cloud-managed: "true"
     include.release.openshift.io/hypershift: "true"
     include.release.openshift.io/self-managed-high-availability: "true"
+    release.openshift.io/delete: "true"
     capability.openshift.io/name: "OperatorLifecycleManager"
   name: collect-profiles
   namespace: openshift-operator-lifecycle-manager
diff --git a/microshift-manifests/0000_50_olm_07-collect-profiles.cronjob.yaml b/microshift-manifests/0000_50_olm_07-collect-profiles.cronjob.yaml
deleted file mode 100644
index eb878c4786..0000000000
--- a/microshift-manifests/0000_50_olm_07-collect-profiles.cronjob.yaml
+++ /dev/null
@@ -1,64 +0,0 @@
-apiVersion: batch/v1
-kind: CronJob
-metadata:
-  annotations:
-    include.release.openshift.io/ibm-cloud-managed: "true"
-    include.release.openshift.io/hypershift: "true"
-    include.release.openshift.io/self-managed-high-availability: "true"
-    capability.openshift.io/name: "OperatorLifecycleManager"
-  name: collect-profiles
-  namespace: openshift-operator-lifecycle-manager
-spec:
-  schedule: "*/15 * * * *"
-  concurrencyPolicy: "Replace"
-  jobTemplate:
-    spec:
-      template:
-        metadata:
-          annotations:
-            target.workload.openshift.io/management: '{"effect": "PreferredDuringScheduling"}'
-            openshift.io/required-scc: restricted-v2
-        spec:
-          securityContext:
-            runAsNonRoot: true
-            seccompProfile:
-              type: RuntimeDefault
-          serviceAccountName: collect-profiles
-          priorityClassName: openshift-user-critical
-          containers:
-            - name: collect-profiles
-              securityContext:
-                allowPrivilegeEscalation: false
-                capabilities:
-                  drop: ["ALL"]
-              image: quay.io/operator-framework/olm@sha256:de396b540b82219812061d0d753440d5655250c621c753ed1dc67d6154741607
-              imagePullPolicy: IfNotPresent
-              command:
-                - bin/collect-profiles
-              args:
-                - -n
-                - openshift-operator-lifecycle-manager
-                - --config-mount-path
-                - /etc/config
-                - --cert-mount-path
-                - /var/run/secrets/serving-cert
-                - olm-operator-heap-:https://olm-operator-metrics:8443/debug/pprof/heap
-                - catalog-operator-heap-:https://catalog-operator-metrics:8443/debug/pprof/heap
-              volumeMounts:
-                - mountPath: /etc/config
-                  name: config-volume
-                - mountPath: /var/run/secrets/serving-cert
-                  name: secret-volume
-              resources:
-                requests:
-                  cpu: 10m
-                  memory: 80Mi
-              terminationMessagePolicy: FallbackToLogsOnError
-          volumes:
-            - name: config-volume
-              configMap:
-                name: collect-profiles-config
-            - name: secret-volume
-              secret:
-                secretName: pprof-cert
-          restartPolicy: Never
diff --git a/scripts/generate_crds_manifests.sh b/scripts/generate_crds_manifests.sh
index 15f0b340d5..c2e31951bf 100755
--- a/scripts/generate_crds_manifests.sh
+++ b/scripts/generate_crds_manifests.sh
@@ -371,6 +371,7 @@ metadata:
     include.release.openshift.io/ibm-cloud-managed: "true"
     include.release.openshift.io/hypershift: "true"
     include.release.openshift.io/self-managed-high-availability: "true"
+    release.openshift.io/delete: "true"
   name: collect-profiles
   namespace: openshift-operator-lifecycle-manager
 spec:
@@ -555,3 +556,8 @@ ${SED} -i '/- --writeStatusName/,+3d' ${ROOT_DIR}/microshift-manifests/0000_50_o
 
 # Replace the namespace openshift, as it doesn't exist on microshift, in the rbac file
 ${SED} -i 's/  namespace: openshift/  namespace: openshift-operator-lifecycle-manager/g' ${ROOT_DIR}/microshift-manifests/0000_50_olm_15-csv-viewer.rbac.yaml
+
+# Deleting manifests from CVO takes multiple releases. an annotation was added in 4.16 development to remove the collect-profiles job
+# from the CVO payload. For microshift, since there is no CVO payload and no in process upgrade, let's delete this now. In 4.17 development,
+# the CVO manifest should be deleted and this step should be removed.
+rm "${ROOT_DIR}/microshift-manifests/0000_50_olm_07-collect-profiles.cronjob.yaml"