diff --git a/xtokens/src/lib.rs b/xtokens/src/lib.rs
index be39c8c85..6165264f4 100644
--- a/xtokens/src/lib.rs
+++ b/xtokens/src/lib.rs
@@ -22,7 +22,13 @@
 #![allow(clippy::unused_unit)]
 #![allow(clippy::large_enum_variant)]
 
-use frame_support::{log, pallet_prelude::*, require_transactional, traits::Get, transactional, Parameter};
+use frame_support::{
+	log,
+	pallet_prelude::*,
+	require_transactional,
+	traits::{Contains, Get},
+	transactional, Parameter,
+};
 use frame_system::{ensure_signed, pallet_prelude::*};
 use sp_runtime::{
 	traits::{AtLeast32BitUnsigned, Convert, MaybeSerializeDeserialize, Member, Zero},
@@ -88,6 +94,9 @@ pub mod module {
 		/// XCM executor.
 		type XcmExecutor: ExecuteXcm<Self::Call>;
 
+		/// MultiLocation filter
+		type MultiLocationsFilter: Contains<MultiLocation>;
+
 		/// Means of measuring the weight consumed by an XCM message locally.
 		type Weigher: WeightBounds<Self::Call>;
 
@@ -158,6 +167,8 @@ pub mod module {
 		AssetIndexNonExistent,
 		/// Fee is not enough.
 		FeeNotEnough,
+		/// Not supported MultiLocation
+		NotSupportedMultiLocation,
 	}
 
 	#[pallet::hooks]
@@ -372,6 +383,10 @@ pub mod module {
 				T::CurrencyIdConvert::convert(currency_id).ok_or(Error::<T>::NotCrossChainTransferableCurrency)?;
 
 			ensure!(!amount.is_zero(), Error::<T>::ZeroAmount);
+			ensure!(
+				T::MultiLocationsFilter::contains(&dest),
+				Error::<T>::NotSupportedMultiLocation
+			);
 
 			let asset: MultiAsset = (location, amount.into()).into();
 			Self::do_transfer_multiassets(who, vec![asset.clone()].into(), asset, dest, dest_weight)
@@ -390,6 +405,10 @@ pub mod module {
 
 			ensure!(!amount.is_zero(), Error::<T>::ZeroAmount);
 			ensure!(!fee.is_zero(), Error::<T>::ZeroFee);
+			ensure!(
+				T::MultiLocationsFilter::contains(&dest),
+				Error::<T>::NotSupportedMultiLocation
+			);
 
 			let asset = (location.clone(), amount.into()).into();
 			let fee_asset: MultiAsset = (location, fee.into()).into();
@@ -439,6 +458,10 @@ pub mod module {
 				currencies.len() <= T::MaxAssetsForTransfer::get(),
 				Error::<T>::TooManyAssetsBeingSent
 			);
+			ensure!(
+				T::MultiLocationsFilter::contains(&dest),
+				Error::<T>::NotSupportedMultiLocation
+			);
 
 			let mut assets = MultiAssets::new();
 
@@ -451,6 +474,7 @@ pub mod module {
 				let location: MultiLocation = T::CurrencyIdConvert::convert(currency_id.clone())
 					.ok_or(Error::<T>::NotCrossChainTransferableCurrency)?;
 				ensure!(!amount.is_zero(), Error::<T>::ZeroAmount);
+
 				// Push contains saturated addition, so we should be able to use it safely
 				assets.push((location, (*amount).into()).into())
 			}
@@ -476,6 +500,10 @@ pub mod module {
 				assets.len() <= T::MaxAssetsForTransfer::get(),
 				Error::<T>::TooManyAssetsBeingSent
 			);
+			ensure!(
+				T::MultiLocationsFilter::contains(&dest),
+				Error::<T>::NotSupportedMultiLocation
+			);
 			let origin_location = T::AccountIdToMultiLocation::convert(who.clone());
 
 			let mut non_fee_reserve: Option<MultiLocation> = None;
diff --git a/xtokens/src/mock/para.rs b/xtokens/src/mock/para.rs
index 689fa3940..609dd7b8c 100644
--- a/xtokens/src/mock/para.rs
+++ b/xtokens/src/mock/para.rs
@@ -2,7 +2,7 @@ use super::{Amount, Balance, CurrencyId, CurrencyIdConvert, ParachainXcmRouter};
 use crate as orml_xtokens;
 
 use frame_support::{
-	construct_runtime, parameter_types,
+	construct_runtime, match_type, parameter_types,
 	traits::{Everything, Get, Nothing},
 	weights::{constants::WEIGHT_PER_SECOND, Weight},
 };
@@ -272,6 +272,17 @@ parameter_types! {
 	pub const MaxAssetsForTransfer: usize = 3;
 }
 
+match_type! {
+	pub type ParentOrParachains: impl Contains<MultiLocation> = {
+		MultiLocation { parents: 0, interior: X1(Junction::AccountId32 { .. }) } |
+		MultiLocation { parents: 1, interior: X1(Junction::AccountId32 { .. }) } |
+		MultiLocation { parents: 1, interior: X2(Parachain(1), Junction::AccountId32 { .. }) } |
+		MultiLocation { parents: 1, interior: X2(Parachain(2), Junction::AccountId32 { .. }) } |
+		MultiLocation { parents: 1, interior: X2(Parachain(3), Junction::AccountId32 { .. }) } |
+		MultiLocation { parents: 1, interior: X2(Parachain(100), Junction::AccountId32 { .. }) }
+	};
+}
+
 parameter_type_with_key! {
 	pub ParachainMinFee: |location: MultiLocation| -> u128 {
 		#[allow(clippy::match_ref_pats)] // false positive
@@ -289,6 +300,7 @@ impl orml_xtokens::Config for Runtime {
 	type CurrencyIdConvert = CurrencyIdConvert;
 	type AccountIdToMultiLocation = AccountIdToMultiLocation;
 	type SelfLocation = SelfLocation;
+	type MultiLocationsFilter = ParentOrParachains;
 	type MinXcmFee = ParachainMinFee;
 	type XcmExecutor = XcmExecutor<XcmConfig>;
 	type Weigher = FixedWeightBounds<UnitWeightCost, Call, MaxInstructions>;
diff --git a/xtokens/src/tests.rs b/xtokens/src/tests.rs
index bb4ce5f60..2b68d35e8 100644
--- a/xtokens/src/tests.rs
+++ b/xtokens/src/tests.rs
@@ -1335,3 +1335,54 @@ fn send_with_zero_amount() {
 
 	// TODO: should have more tests after https://github.com/paritytech/polkadot/issues/4996
 }
+
+#[test]
+fn unsupported_multilocation_should_be_filtered() {
+	TestNet::reset();
+
+	ParaB::execute_with(|| {
+		assert_ok!(ParaTokens::deposit(CurrencyId::B, &ALICE, 1_000));
+		assert_ok!(ParaTokens::deposit(CurrencyId::B1, &ALICE, 1_000));
+		assert_noop!(
+			ParaXTokens::transfer(
+				Some(ALICE).into(),
+				CurrencyId::B,
+				500,
+				Box::new(
+					(
+						Parent,
+						Parachain(4), // parachain 4 is not supported list.
+						Junction::AccountId32 {
+							network: NetworkId::Any,
+							id: BOB.into(),
+						},
+					)
+						.into()
+				),
+				40,
+			),
+			Error::<para::Runtime>::NotSupportedMultiLocation
+		);
+
+		assert_noop!(
+			ParaXTokens::transfer_multicurrencies(
+				Some(ALICE).into(),
+				vec![(CurrencyId::B1, 50), (CurrencyId::B, 450)],
+				0,
+				Box::new(
+					(
+						Parent,
+						Parachain(4),
+						Junction::AccountId32 {
+							network: NetworkId::Any,
+							id: BOB.into(),
+						},
+					)
+						.into()
+				),
+				40,
+			),
+			Error::<para::Runtime>::NotSupportedMultiLocation
+		);
+	});
+}