diff --git a/.github/workflows/test.yml b/.github/workflows/test.yml
index f451d62ed6..9f4f7cf177 100644
--- a/.github/workflows/test.yml
+++ b/.github/workflows/test.yml
@@ -16,13 +16,14 @@ jobs:
       py37: 3.7
       py38: 3.8
       py39: 3.9
+      py310: "3.10"
       pypy3: pypy3
       RUN_MATRIX_COMBINATION: ${{ matrix.python-version }}-${{ matrix.package }}-${{ matrix.os }}
     runs-on: ${{ matrix.os }}
     strategy:
       fail-fast: false  # ensures the entire test matrix is run, even if one permutation fails
       matrix:
-        python-version: [ py36, py37, py38, py39, pypy3 ]
+        python-version: [ py36, py37, py38, py39, py310, pypy3 ]
         package: ["instrumentation", "distro", "exporter", "sdkextension", "propagator"]
         os: [ ubuntu-20.04 ]
     steps:
diff --git a/CHANGELOG.md b/CHANGELOG.md
index 8302383ec3..feb5441eff 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -8,6 +8,8 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 ## [Unreleased](https://github.com/open-telemetry/opentelemetry-python/compare/v1.6.2-0.25b2...HEAD)
 - `opentelemetry-instrumentation-aws-lambda` Add instrumentation for AWS Lambda Service - pkg metadata files (Part 1/2)
   ([#739](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/739))
+- Add support for Python 3.10
+  ([#742](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/742))
 
 ### Fixed
 
diff --git a/_template/setup.cfg b/_template/setup.cfg
index 5367f6bbbd..62d74d1d9b 100644
--- a/_template/setup.cfg
+++ b/_template/setup.cfg
@@ -38,6 +38,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/exporter/opentelemetry-exporter-datadog/setup.cfg b/exporter/opentelemetry-exporter-datadog/setup.cfg
index 34d7dfc259..046729afa5 100644
--- a/exporter/opentelemetry-exporter-datadog/setup.cfg
+++ b/exporter/opentelemetry-exporter-datadog/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/exporter/opentelemetry-exporter-richconsole/setup.cfg b/exporter/opentelemetry-exporter-richconsole/setup.cfg
index 0e3c855542..0b9f9ea428 100644
--- a/exporter/opentelemetry-exporter-richconsole/setup.cfg
+++ b/exporter/opentelemetry-exporter-richconsole/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-aiohttp-client/setup.cfg b/instrumentation/opentelemetry-instrumentation-aiohttp-client/setup.cfg
index cd96fdc756..d8e6da5296 100644
--- a/instrumentation/opentelemetry-instrumentation-aiohttp-client/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-aiohttp-client/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6.3
diff --git a/instrumentation/opentelemetry-instrumentation-aiopg/setup.cfg b/instrumentation/opentelemetry-instrumentation-aiopg/setup.cfg
index 81f6620492..1149cd6af3 100644
--- a/instrumentation/opentelemetry-instrumentation-aiopg/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-aiopg/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-asgi/setup.cfg b/instrumentation/opentelemetry-instrumentation-asgi/setup.cfg
index 06468dafb5..163d096942 100644
--- a/instrumentation/opentelemetry-instrumentation-asgi/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-asgi/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-asyncpg/setup.cfg b/instrumentation/opentelemetry-instrumentation-asyncpg/setup.cfg
index 93a2936f90..cb0b9d9487 100644
--- a/instrumentation/opentelemetry-instrumentation-asyncpg/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-asyncpg/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-boto/setup.cfg b/instrumentation/opentelemetry-instrumentation-boto/setup.cfg
index 075dd7af26..8315b17f25 100644
--- a/instrumentation/opentelemetry-instrumentation-boto/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-boto/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-botocore/setup.cfg b/instrumentation/opentelemetry-instrumentation-botocore/setup.cfg
index b6dcd5378a..de9716df90 100644
--- a/instrumentation/opentelemetry-instrumentation-botocore/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-botocore/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-celery/setup.cfg b/instrumentation/opentelemetry-instrumentation-celery/setup.cfg
index ee3117d04a..70180977af 100644
--- a/instrumentation/opentelemetry-instrumentation-celery/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-celery/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-dbapi/setup.cfg b/instrumentation/opentelemetry-instrumentation-dbapi/setup.cfg
index 3cc9d801b0..0908cd43cb 100644
--- a/instrumentation/opentelemetry-instrumentation-dbapi/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-dbapi/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-django/setup.cfg b/instrumentation/opentelemetry-instrumentation-django/setup.cfg
index 493e798536..712948a46f 100644
--- a/instrumentation/opentelemetry-instrumentation-django/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-django/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-elasticsearch/setup.cfg b/instrumentation/opentelemetry-instrumentation-elasticsearch/setup.cfg
index 66f0bd36c9..7239edee30 100644
--- a/instrumentation/opentelemetry-instrumentation-elasticsearch/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-elasticsearch/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-falcon/setup.cfg b/instrumentation/opentelemetry-instrumentation-falcon/setup.cfg
index e39c8d3dc2..7e7ca0cf2b 100644
--- a/instrumentation/opentelemetry-instrumentation-falcon/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-falcon/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-fastapi/setup.cfg b/instrumentation/opentelemetry-instrumentation-fastapi/setup.cfg
index a06617dcda..6ce76ef762 100644
--- a/instrumentation/opentelemetry-instrumentation-fastapi/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-fastapi/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-flask/setup.cfg b/instrumentation/opentelemetry-instrumentation-flask/setup.cfg
index 31b9324812..7a96f03aad 100644
--- a/instrumentation/opentelemetry-instrumentation-flask/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-flask/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-grpc/setup.cfg b/instrumentation/opentelemetry-instrumentation-grpc/setup.cfg
index a075efa324..170fcd17de 100644
--- a/instrumentation/opentelemetry-instrumentation-grpc/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-grpc/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-httpx/setup.cfg b/instrumentation/opentelemetry-instrumentation-httpx/setup.cfg
index bab85edff5..563bf98f23 100644
--- a/instrumentation/opentelemetry-instrumentation-httpx/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-httpx/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-jinja2/setup.cfg b/instrumentation/opentelemetry-instrumentation-jinja2/setup.cfg
index 5d95076732..72e2bb775d 100644
--- a/instrumentation/opentelemetry-instrumentation-jinja2/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-jinja2/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 package_dir=
diff --git a/instrumentation/opentelemetry-instrumentation-logging/setup.cfg b/instrumentation/opentelemetry-instrumentation-logging/setup.cfg
index 6fc3b3d070..1c47a5598d 100644
--- a/instrumentation/opentelemetry-instrumentation-logging/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-logging/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 package_dir=
diff --git a/instrumentation/opentelemetry-instrumentation-mysql/setup.cfg b/instrumentation/opentelemetry-instrumentation-mysql/setup.cfg
index 8f4e0107fe..6fae89d1c6 100644
--- a/instrumentation/opentelemetry-instrumentation-mysql/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-mysql/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-pika/setup.cfg b/instrumentation/opentelemetry-instrumentation-pika/setup.cfg
index df7b145c0b..976fb84a6c 100644
--- a/instrumentation/opentelemetry-instrumentation-pika/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-pika/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-psycopg2/setup.cfg b/instrumentation/opentelemetry-instrumentation-psycopg2/setup.cfg
index 1369622bd5..5acb766888 100644
--- a/instrumentation/opentelemetry-instrumentation-psycopg2/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-psycopg2/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-pymemcache/setup.cfg b/instrumentation/opentelemetry-instrumentation-pymemcache/setup.cfg
index d280b25600..922d67a4a7 100644
--- a/instrumentation/opentelemetry-instrumentation-pymemcache/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-pymemcache/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-pymongo/setup.cfg b/instrumentation/opentelemetry-instrumentation-pymongo/setup.cfg
index e6ab0f5284..f8b8b39529 100644
--- a/instrumentation/opentelemetry-instrumentation-pymongo/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-pymongo/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-pymysql/setup.cfg b/instrumentation/opentelemetry-instrumentation-pymysql/setup.cfg
index 2ef9c1bdea..60c4f4aa39 100644
--- a/instrumentation/opentelemetry-instrumentation-pymysql/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-pymysql/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-pyramid/setup.cfg b/instrumentation/opentelemetry-instrumentation-pyramid/setup.cfg
index cf057a54ef..e4c84cb090 100644
--- a/instrumentation/opentelemetry-instrumentation-pyramid/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-pyramid/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-redis/setup.cfg b/instrumentation/opentelemetry-instrumentation-redis/setup.cfg
index 96685ac08b..72058eba64 100644
--- a/instrumentation/opentelemetry-instrumentation-redis/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-redis/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-requests/setup.cfg b/instrumentation/opentelemetry-instrumentation-requests/setup.cfg
index a502903d04..856d950d37 100644
--- a/instrumentation/opentelemetry-instrumentation-requests/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-requests/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-sklearn/setup.cfg b/instrumentation/opentelemetry-instrumentation-sklearn/setup.cfg
index fae53774c6..2cabb209c7 100644
--- a/instrumentation/opentelemetry-instrumentation-sklearn/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-sklearn/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-sqlalchemy/setup.cfg b/instrumentation/opentelemetry-instrumentation-sqlalchemy/setup.cfg
index bdd19e2a11..f5392c4871 100644
--- a/instrumentation/opentelemetry-instrumentation-sqlalchemy/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-sqlalchemy/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-sqlite3/setup.cfg b/instrumentation/opentelemetry-instrumentation-sqlite3/setup.cfg
index 3f58398b6f..a8dc52f552 100644
--- a/instrumentation/opentelemetry-instrumentation-sqlite3/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-sqlite3/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-starlette/setup.cfg b/instrumentation/opentelemetry-instrumentation-starlette/setup.cfg
index 6d6c7805ca..3be212a5c1 100644
--- a/instrumentation/opentelemetry-instrumentation-starlette/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-starlette/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-tornado/setup.cfg b/instrumentation/opentelemetry-instrumentation-tornado/setup.cfg
index 8c31a251bc..db3f4f94f3 100644
--- a/instrumentation/opentelemetry-instrumentation-tornado/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-tornado/setup.cfg
@@ -31,6 +31,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-urllib/setup.cfg b/instrumentation/opentelemetry-instrumentation-urllib/setup.cfg
index fce546944e..454c297a52 100644
--- a/instrumentation/opentelemetry-instrumentation-urllib/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-urllib/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-urllib3/setup.cfg b/instrumentation/opentelemetry-instrumentation-urllib3/setup.cfg
index 0606ccebdd..af7e2ab089 100644
--- a/instrumentation/opentelemetry-instrumentation-urllib3/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-urllib3/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/instrumentation/opentelemetry-instrumentation-wsgi/setup.cfg b/instrumentation/opentelemetry-instrumentation-wsgi/setup.cfg
index 4cd89fd206..b1ce85f30a 100644
--- a/instrumentation/opentelemetry-instrumentation-wsgi/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-wsgi/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/opentelemetry-instrumentation/setup.cfg b/opentelemetry-instrumentation/setup.cfg
index 042f0edb19..4c61cf0a60 100644
--- a/opentelemetry-instrumentation/setup.cfg
+++ b/opentelemetry-instrumentation/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/propagator/opentelemetry-propagator-aws-xray/setup.cfg b/propagator/opentelemetry-propagator-aws-xray/setup.cfg
index 00612aa3a6..171abb55f4 100644
--- a/propagator/opentelemetry-propagator-aws-xray/setup.cfg
+++ b/propagator/opentelemetry-propagator-aws-xray/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/propagator/opentelemetry-propagator-ot-trace/setup.cfg b/propagator/opentelemetry-propagator-ot-trace/setup.cfg
index de164d1875..c5ebbfdeac 100644
--- a/propagator/opentelemetry-propagator-ot-trace/setup.cfg
+++ b/propagator/opentelemetry-propagator-ot-trace/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/sdk-extension/opentelemetry-sdk-extension-aws/setup.cfg b/sdk-extension/opentelemetry-sdk-extension-aws/setup.cfg
index 7e81f63aed..ef1fa1f85b 100644
--- a/sdk-extension/opentelemetry-sdk-extension-aws/setup.cfg
+++ b/sdk-extension/opentelemetry-sdk-extension-aws/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6
diff --git a/tox.ini b/tox.ini
index 20dacc834c..aa169d1f7c 100644
--- a/tox.ini
+++ b/tox.ini
@@ -6,167 +6,171 @@ envlist =
     ; for specifying supported Python versions per package.
 
     ; opentelemetry-sdk-extension-aws
-    py3{6,7,8,9}-test-sdkextension-aws
+    py3{6,7,8,9,10}-test-sdkextension-aws
     pypy3-test-sdkextension-aws
 
     ; opentelemetry-distro
-    py3{6,7,8,9}-test-distro
+    py3{6,7,8,9,10}-test-distro
     pypy3-test-distro
 
     ; opentelemetry-instrumentation
-    py3{6,7,8,9}-test-opentelemetry-instrumentation
+    py3{6,7,8,9,10}-test-opentelemetry-instrumentation
     pypy3-test-opentelemetry-instrumentation
 
     ; opentelemetry-instrumentation-aiohttp-client
-    py3{6,7,8,9}-test-instrumentation-aiohttp-client
+    py3{6,7,8,9,10}-test-instrumentation-aiohttp-client
     pypy3-test-instrumentation-aiohttp-client
 
     ; opentelemetry-instrumentation-aiopg
-    py3{6,7,8,9}-test-instrumentation-aiopg
+    py3{6,7,8,9,10}-test-instrumentation-aiopg
     ; instrumentation-aiopg intentionally excluded from pypy3
 
     ; opentelemetry-instrumentation-botocore
-    py3{6,7,8,9}-test-instrumentation-botocore
+    py3{6,7,8,9,10}-test-instrumentation-botocore
     pypy3-test-instrumentation-botocore
 
     ; opentelemetry-instrumentation-django
-    py3{6,7,8,9}-test-instrumentation-django
+    py3{6,7,8,9,10}-test-instrumentation-django
     pypy3-test-instrumentation-django
 
     ; opentelemetry-instrumentation-dbapi
-    py3{6,7,8,9}-test-instrumentation-dbapi
+    py3{6,7,8,9,10}-test-instrumentation-dbapi
     pypy3-test-instrumentation-dbapi
 
     ; opentelemetry-instrumentation-boto
-    py3{6,7,8,9}-test-instrumentation-boto
+    py3{6,7,8,9,10}-test-instrumentation-boto
     pypy3-test-instrumentation-boto
 
     ; opentelemetry-instrumentation-elasticsearch
-    py3{6,7,8,9}-test-instrumentation-elasticsearch{2,5,6}
-    pypy3-test-instrumentation-elasticsearch{2,5,6}
+    py3{6,7,8,9,10}-test-instrumentation-elasticsearch{2,6}
+    pypy3-test-instrumentation-elasticsearch{2,6}
+
+    ; opentelemetry-instrumentation-elasticsearch5
+    py3{6,7,8,9}-test-instrumentation-elasticsearch5
+    pypy3-test-instrumentation-elasticsearch5
 
     ; opentelemetry-instrumentation-falcon
-    py3{6,7,8,9}-test-instrumentation-falcon{2,3}
+    py3{6,7,8,9,10}-test-instrumentation-falcon{2,3}
     pypy3-test-instrumentation-falcon{2,3}
 
     ; opentelemetry-instrumentation-fastapi
     ; fastapi only supports 3.6 and above.
-    py3{6,7,8,9}-test-instrumentation-fastapi
+    py3{6,7,8,9,10}-test-instrumentation-fastapi
     pypy3-test-instrumentation-fastapi
 
     ; opentelemetry-instrumentation-flask
-    py3{6,7,8,9}-test-instrumentation-flask
+    py3{6,7,8,9,10}-test-instrumentation-flask
     pypy3-test-instrumentation-flask
 
     ; opentelemetry-instrumentation-urllib
-    py3{6,7,8,9}-test-instrumentation-urllib
+    py3{6,7,8,9,10}-test-instrumentation-urllib
     pypy3-test-instrumentation-urllib
 
     ; opentelemetry-instrumentation-urllib3
-    py3{6,7,8,9}-test-instrumentation-urllib3
+    py3{6,7,8,9,10}-test-instrumentation-urllib3
     pypy3-test-instrumentation-urllib3
 
     ; opentelemetry-instrumentation-requests
-    py3{6,7,8,9}-test-instrumentation-requests
+    py3{6,7,8,9,10}-test-instrumentation-requests
     pypy3-test-instrumentation-requests
 
     ; opentelemetry-instrumentation-starlette.
     ; starlette only supports 3.6 and above.
-    py3{6,7,8,9}-test-instrumentation-starlette
+    py3{6,7,8,9,10}-test-instrumentation-starlette
     pypy3-test-instrumentation-starlette
 
     ; opentelemetry-instrumentation-jinja2
-    py3{6,7,8,9}-test-instrumentation-jinja2
+    py3{6,7,8,9,10}-test-instrumentation-jinja2
     pypy3-test-instrumentation-jinja2
 
     ; opentelemetry-instrumentation-logging
-    py3{6,7,8,9}-test-instrumentation-logging
+    py3{6,7,8,9,10}-test-instrumentation-logging
     pypy3-test-instrumentation-logging
 
     ; opentelemetry-exporter-datadog
-    py3{6,7,8,9}-test-exporter-datadog
+    py3{6,7,8,9,10}-test-exporter-datadog
 
     ; opentelemetry-instrumentation-mysql
-    py3{6,7,8,9}-test-instrumentation-mysql
+    py3{6,7,8,9,10}-test-instrumentation-mysql
     pypy3-test-instrumentation-mysql
 
     ; opentelemetry-instrumentation-psycopg2
-    py3{6,7,8,9}-test-instrumentation-psycopg2
+    py3{6,7,8,9,10}-test-instrumentation-psycopg2
     ; ext-psycopg2 intentionally excluded from pypy3
 
     ; opentelemetry-instrumentation-pymemcache
-    py3{6,7,8,9}-test-instrumentation-pymemcache
+    py3{6,7,8,9,10}-test-instrumentation-pymemcache
     pypy3-test-instrumentation-pymemcache
 
     ; opentelemetry-instrumentation-pymongo
-    py3{6,7,8,9}-test-instrumentation-pymongo
+    py3{6,7,8,9,10}-test-instrumentation-pymongo
     pypy3-test-instrumentation-pymongo
 
     ; opentelemetry-instrumentation-pymysql
-    py3{6,7,8,9}-test-instrumentation-pymysql
+    py3{6,7,8,9,10}-test-instrumentation-pymysql
     pypy3-test-instrumentation-pymysql
 
     ; opentelemetry-instrumentation-pyramid
-    py3{6,7,8,9}-test-instrumentation-pyramid
+    py3{6,7,8,9,10}-test-instrumentation-pyramid
     pypy3-test-instrumentation-pyramid
 
     ; opentelemetry-instrumentation-asgi
-    py3{6,7,8,9}-test-instrumentation-asgi
+    py3{6,7,8,9,10}-test-instrumentation-asgi
     pypy3-test-instrumentation-asgi
 
     ; opentelemetry-instrumentation-asyncpg
-    py3{6,7,8,9}-test-instrumentation-asyncpg
+    py3{6,7,8,9,10}-test-instrumentation-asyncpg
     ; ext-asyncpg intentionally excluded from pypy3
 
     ; opentelemetry-instrumentation-sqlite3
-    py3{6,7,8,9}-test-instrumentation-sqlite3
+    py3{6,7,8,9,10}-test-instrumentation-sqlite3
     pypy3-test-instrumentation-sqlite3
 
     ; opentelemetry-instrumentation-wsgi
-    py3{6,7,8,9}-test-instrumentation-wsgi
+    py3{6,7,8,9,10}-test-instrumentation-wsgi
     pypy3-test-instrumentation-wsgi
 
     ; opentelemetry-instrumentation-grpc
-    py3{6,7,8,9}-test-instrumentation-grpc
+    py3{6,7,8,9,10}-test-instrumentation-grpc
 
     ; opentelemetry-instrumentation-sqlalchemy
     py3{6,7}-test-instrumentation-sqlalchemy{11}
-    py3{6,7,8,9}-test-instrumentation-sqlalchemy{14}
+    py3{6,7,8,9,10}-test-instrumentation-sqlalchemy{14}
     pypy3-test-instrumentation-sqlalchemy{11,14}
 
     ; opentelemetry-instrumentation-redis
-    py3{6,7,8,9}-test-instrumentation-redis
+    py3{6,7,8,9,10}-test-instrumentation-redis
     pypy3-test-instrumentation-redis
 
     ; opentelemetry-instrumentation-celery
-    py3{6,7,8,9}-test-instrumentation-celery
+    py3{6,7,8,9,10}-test-instrumentation-celery
     pypy3-test-instrumentation-celery
 
     ; opentelemetry-instrumentation-sklearn
     py3{6,7,8}-test-instrumentation-sklearn
 
     ; opentelemetry-instrumentation-tornado
-    py3{6,7,8,9}-test-instrumentation-tornado
+    py3{6,7,8,9,10}-test-instrumentation-tornado
     pypy3-test-instrumentation-tornado
 
     ; opentelemetry-instrumentation-httpx
-    py3{6,7,8,9}-test-instrumentation-httpx
+    py3{6,7,8,9,10}-test-instrumentation-httpx
     pypy3-test-instrumentation-httpx
 
     ; opentelemetry-util-http
-    py3{6,7,8,9}-test-util-http
+    py3{6,7,8,9,10}-test-util-http
     pypy3-test-util-http
 
     ; opentelemetry-propagator-aws-xray
-    py3{6,7,8,9}-test-propagator-aws-xray
+    py3{6,7,8,9,10}-test-propagator-aws-xray
     pypy3-test-propagator-aws-xray
 
     ; opentelemetry-propagator-ot-trace
-    py3{6,7,8,9}-test-propagator-ot-trace
+    py3{6,7,8,9,10}-test-propagator-ot-trace
     pypy3-test-propagator-ot-trace
 
     ; opentelemetry-instrumentation-pika
-    py3{6,7,8,9}-test-instrumentation-pika
+    py3{6,7,8,9,10}-test-instrumentation-pika
     pypy3-test-instrumentation-pika
 
     lint
@@ -251,7 +255,7 @@ changedir =
 
 commands_pre =
 ; Install without -e to test the actual installation
-  py3{6,7,8,9}: python -m pip install -U pip setuptools wheel
+  py3{6,7,8,9,10}: python -m pip install -U pip setuptools wheel
 ; Install common packages for all the tests. These are not needed in all the
 ; cases but it saves a lot of boilerplate in this file.
   test: pip install "opentelemetry-api[test] @ {env:CORE_REPO}#egg=opentelemetry-api&subdirectory=opentelemetry-api"
diff --git a/util/opentelemetry-util-http/setup.cfg b/util/opentelemetry-util-http/setup.cfg
index 6e8c78f322..8abce2cb06 100644
--- a/util/opentelemetry-util-http/setup.cfg
+++ b/util/opentelemetry-util-http/setup.cfg
@@ -32,6 +32,7 @@ classifiers =
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [options]
 python_requires = >=3.6