diff --git a/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/_server.py b/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/_server.py
index 1d744656de..675ac8e383 100644
--- a/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/_server.py
+++ b/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/_server.py
@@ -29,6 +29,7 @@
 
 from opentelemetry import trace
 from opentelemetry.context import attach, detach
+from opentelemetry.instrumentation.utils import is_instrumentation_enabled
 from opentelemetry.propagate import extract
 from opentelemetry.semconv._incubating.attributes.net_attributes import (
     NET_PEER_IP,
@@ -279,7 +280,9 @@ def _start_span(
         )
 
     def intercept_service(self, continuation, handler_call_details):
-        if self._filter is not None and not self._filter(handler_call_details):
+        if (
+            self._filter is not None and not self._filter(handler_call_details)
+        ) or not is_instrumentation_enabled():
             return continuation(handler_call_details)
 
         def telemetry_wrapper(behavior, request_streaming, response_streaming):