diff --git a/instrumentation/opentelemetry-instrumentation-httpx/pyproject.toml b/instrumentation/opentelemetry-instrumentation-httpx/pyproject.toml
index f13fa816bc..1a4da4a520 100644
--- a/instrumentation/opentelemetry-instrumentation-httpx/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-httpx/pyproject.toml
@@ -34,11 +34,6 @@ dependencies = [
 instruments = [
   "httpx >= 0.18.0",
 ]
-test = [
-  "opentelemetry-instrumentation-httpx[instruments]",
-  "opentelemetry-sdk ~= 1.12",
-  "opentelemetry-test-utils == 0.45b0.dev",
-]
 
 [project.entry-points.opentelemetry_instrumentor]
 httpx = "opentelemetry.instrumentation.httpx:HTTPXClientInstrumentor"
diff --git a/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-0.txt
new file mode 100644
index 0000000000..2d3a8399d8
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-0.txt
@@ -0,0 +1,28 @@
+anyio==3.7.1
+asgiref==3.7.2
+attrs==23.2.0
+certifi==2024.2.2
+Deprecated==1.2.14
+exceptiongroup==1.2.0
+h11==0.12.0
+httpcore==0.13.7
+httpx==0.18.2
+idna==3.6
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+respx==0.17.1
+rfc3986==1.5.0
+sniffio==1.3.1
+tomli==2.0.1
+typing_extensions==4.10.0
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e util/opentelemetry-util-http
+-e instrumentation/opentelemetry-instrumentation-httpx
diff --git a/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-1.txt
new file mode 100644
index 0000000000..4a36398fc1
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-1.txt
@@ -0,0 +1,27 @@
+anyio==4.3.0
+asgiref==3.7.2
+attrs==23.2.0
+certifi==2024.2.2
+Deprecated==1.2.14
+exceptiongroup==1.2.0
+h11==0.14.0
+httpcore==1.0.4
+httpx==0.27.0
+idna==3.6
+importlib-metadata==6.11.0
+iniconfig==2.0.0
+packaging==23.2
+pluggy==1.4.0
+py==1.11.0
+py-cpuinfo==9.0.0
+pytest==7.1.3
+pytest-benchmark==4.0.0
+respx==0.20.2
+sniffio==1.3.1
+tomli==2.0.1
+typing_extensions==4.10.0
+wrapt==1.16.0
+zipp==3.17.0
+-e opentelemetry-instrumentation
+-e util/opentelemetry-util-http
+-e instrumentation/opentelemetry-instrumentation-httpx
diff --git a/tox.ini b/tox.ini
index bf2a9dc64c..4e5832fbf8 100644
--- a/tox.ini
+++ b/tox.ini
@@ -221,8 +221,8 @@ envlist =
     pypy3-test-instrumentation-tortoiseorm
 
     ; opentelemetry-instrumentation-httpx
-    py3{8,9,10,11}-test-instrumentation-httpx-{18,21}
-    pypy3-test-instrumentation-httpx-{18,21}
+    py3{8,9,10,11}-test-instrumentation-httpx-{0,1}
+    pypy3-test-instrumentation-httpx-{0,1}
 
     ; opentelemetry-util-http
     py3{8,9,10,11}-test-util-http
@@ -300,10 +300,6 @@ deps =
   pymemcache-300: pymemcache >3.0.0,<3.4.2
   pymemcache-342: pymemcache ==3.4.2
   pymemcache-400: pymemcache ==4.0.0
-  httpx-18: httpx>=0.18.0,<0.19.0
-  httpx-18: respx~=0.17.0
-  httpx-21: httpx>=0.19.0
-  httpx-21: respx~=0.20.1
   urllib3v-1: urllib3 >=1.0.0,<2.0.0
   urllib3v-2: urllib3 >=2.0.0,<3.0.0
 
@@ -345,7 +341,7 @@ commands_pre =
 
   grpc: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-grpc[test]
 
-  httpx-{18,21},requests,urllib,urllib3v-{1,2}: pip install {toxinidir}/util/opentelemetry-util-http
+  requests,urllib,urllib3v-{1,2}: pip install {toxinidir}/util/opentelemetry-util-http
 
   wsgi: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-wsgi/test-requirements.txt
 
@@ -422,7 +418,7 @@ commands_pre =
 
   logging: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-logging[test]
 
-  aio-pika-{8,9}: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-aio-pika[test]
+  aio-pika-{0,1,2}: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-2.txt
 
   aiohttp-client: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-aiohttp-client/test-requirements.txt
 
@@ -442,7 +438,12 @@ commands_pre =
 
   asyncio: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-asyncio/test-requirements.txt
 
-  httpx-{18,21}: pip install {toxinidir}/instrumentation/opentelemetry-instrumentation-httpx[test]
+  ; The numbers at the end of the environment names
+  ; below mean these dependencies are being used:
+  ; 0: httpx>=0.18.0,<0.19.0 respx~=0.17.0
+  ; 1: httpx>=0.19.0 respx~=0.20.1
+  httpx-0: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-0.txt
+  httpx-1: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-1.txt
 
   sdkextension-aws: pip install {toxinidir}/sdk-extension/opentelemetry-sdk-extension-aws[test]
 
@@ -472,13 +473,13 @@ commands =
   test-instrumentation-cassandra: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-cassandra/tests {posargs}
   test-instrumentation-celery: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-celery/tests {posargs}
   test-instrumentation-dbapi: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-dbapi/tests {posargs}
-  test-instrumentation-django-{1,2,3,4}: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-django/tests {posargs}
-  test-instrumentation-elasticsearch-{2,5,6}: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-elasticsearch/tests {posargs}
-  test-instrumentation-falcon-{1,2,3}: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-falcon/tests {posargs}
+  test-instrumentation-django: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-django/tests {posargs}
+  test-instrumentation-elasticsearch: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-elasticsearch/tests {posargs}
+  test-instrumentation-falcon: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-falcon/tests {posargs}
   test-instrumentation-fastapi: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-fastapi/tests {posargs}
-  test-instrumentation-flask-{213,220,300}: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-flask/tests {posargs}
+  test-instrumentation-flask: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-flask/tests {posargs}
   test-instrumentation-urllib: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-urllib/tests {posargs}
-  test-instrumentation-urllib3v-{1,2}: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-urllib3/tests {posargs}
+  test-instrumentation-urllib3v: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-urllib3/tests {posargs}
   test-instrumentation-grpc: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-grpc/tests {posargs}
   test-instrumentation-jinja2: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-jinja2/tests {posargs}
   test-instrumentation-kafka-python: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-kafka-python/tests {posargs}
@@ -486,11 +487,11 @@ commands =
   test-instrumentation-logging: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-logging/tests {posargs}
   test-instrumentation-mysql: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-mysql/tests {posargs}
   test-instrumentation-mysqlclient: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-mysqlclient/tests {posargs}
-  test-instrumentation-sio-pika-{0,1}: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-pika/tests {posargs}
-  test-instrumentation-aio-pika-{8,9}: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-aio-pika/tests {posargs}
+  test-instrumentation-sio-pika: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-pika/tests {posargs}
+  test-instrumentation-aio-pika: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-aio-pika/tests {posargs}
   test-instrumentation-psycopg: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-psycopg/tests {posargs}
   test-instrumentation-psycopg2: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-psycopg2/tests {posargs}
-  test-instrumentation-pymemcache-{135,200,300,342,400}: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-pymemcache/tests {posargs}
+  test-instrumentation-pymemcache: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-pymemcache/tests {posargs}
   test-instrumentation-pymongo: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-pymongo/tests {posargs}
   test-instrumentation-pymysql: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-pymysql/tests {posargs}
   test-instrumentation-pyramid: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-pyramid/tests {posargs}
@@ -498,14 +499,14 @@ commands =
   test-instrumentation-remoulade: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-remoulade/tests {posargs}
   test-instrumentation-requests: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-requests/tests {posargs}
   test-instrumentation-sklearn: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-sklearn/tests {posargs}
-  test-instrumentation-sqlalchemy-{11,14}: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-sqlalchemy/tests {posargs}
+  test-instrumentation-sqlalchemy: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-sqlalchemy/tests {posargs}
   test-instrumentation-sqlite3: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-sqlite3/tests {posargs}
   test-instrumentation-starlette: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-starlette/tests {posargs}
   test-instrumentation-system-metrics: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-system-metrics/tests {posargs}
   test-instrumentation-tornado: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-tornado/tests {posargs}
   test-instrumentation-tortoiseorm: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-tortoiseorm/tests {posargs}
   test-instrumentation-wsgi: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-wsgi/tests {posargs}
-  test-instrumentation-httpx-{18,21}: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-httpx/tests {posargs}
+  test-instrumentation-httpx: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-httpx/tests {posargs}
   test-instrumentation-asyncio: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-asyncio/tests {posargs}
   test-util-http: pytest {toxinidir}/util/opentelemetry-util-http/tests {posargs}
   test-sdkextension-aws: pytest {toxinidir}/sdk-extension/opentelemetry-sdk-extension-aws/tests {posargs}
@@ -601,7 +602,7 @@ commands_pre =
   pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-tornado/test-requirements.txt
   python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-tortoiseorm[test]
   python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-mysql[test]
-  python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-httpx[test]
+  pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-1.txt
   python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-aws-lambda[test]
   python -m pip install -e {toxinidir}/instrumentation/opentelemetry-instrumentation-system-metrics[test]
   pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-asyncio/test-requirements.txt