diff --git a/CHANGELOG.md b/CHANGELOG.md
index f597d64da9..50f290300c 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -7,6 +7,8 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 
 ## Unreleased
 
+- `opentelemetry-instrumentation-django` Handle exceptions from request/response hooks
+  ([#2153](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2153))
 - `opentelemetry-instrumentation-asyncio` instrumented `asyncio.wait_for` properly raises `asyncio.TimeoutError` as expected
   ([#2637](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2637))
 - `opentelemetry-instrumentation-aws-lambda` Bugfix: AWS Lambda event source key incorrect for SNS in instrumentation library. 
@@ -151,7 +153,8 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
   ([#2136](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2136))
 - `opentelemetry-resource-detector-azure` Suppress instrumentation for `urllib` call
   ([#2178](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2178))
-- AwsLambdaInstrumentor handles and re-raises function exception ([#2245](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2245))
+- AwsLambdaInstrumentor handles and re-raises function exception
+  ([#2245](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2245))
 
 ### Added
 
diff --git a/instrumentation/opentelemetry-instrumentation-django/src/opentelemetry/instrumentation/django/middleware/otel_middleware.py b/instrumentation/opentelemetry-instrumentation-django/src/opentelemetry/instrumentation/django/middleware/otel_middleware.py
index 1b747fd2c0..6b64865ef7 100644
--- a/instrumentation/opentelemetry-instrumentation-django/src/opentelemetry/instrumentation/django/middleware/otel_middleware.py
+++ b/instrumentation/opentelemetry-instrumentation-django/src/opentelemetry/instrumentation/django/middleware/otel_middleware.py
@@ -187,6 +187,7 @@ def _get_span_name(request):
             return request.method
 
     # pylint: disable=too-many-locals
+    # pylint: disable=too-many-branches
     def process_request(self, request):
         # request.META is a dictionary containing all available HTTP headers
         # Read more about request.META here:
@@ -286,9 +287,14 @@ def process_request(self, request):
             request.META[self._environ_token] = token
 
         if _DjangoMiddleware._otel_request_hook:
-            _DjangoMiddleware._otel_request_hook(  # pylint: disable=not-callable
-                span, request
-            )
+            try:
+                _DjangoMiddleware._otel_request_hook(  # pylint: disable=not-callable
+                    span, request
+                )
+            except Exception:  # pylint: disable=broad-exception-caught
+                # Raising an exception here would leak the request span since process_response
+                # would not be called. Log the exception instead.
+                _logger.exception("Exception raised by request_hook")
 
     # pylint: disable=unused-argument
     def process_view(self, request, view_func, *args, **kwargs):
@@ -385,10 +391,14 @@ def process_response(self, request, response):
 
             # record any exceptions raised while processing the request
             exception = request.META.pop(self._environ_exception_key, None)
+
             if _DjangoMiddleware._otel_response_hook:
-                _DjangoMiddleware._otel_response_hook(  # pylint: disable=not-callable
-                    span, request, response
-                )
+                try:
+                    _DjangoMiddleware._otel_response_hook(  # pylint: disable=not-callable
+                        span, request, response
+                    )
+                except Exception:  # pylint: disable=broad-exception-caught
+                    _logger.exception("Exception raised by response_hook")
 
             if exception:
                 activation.__exit__(
diff --git a/instrumentation/opentelemetry-instrumentation-django/tests/test_middleware.py b/instrumentation/opentelemetry-instrumentation-django/tests/test_middleware.py
index 63af1e6b86..c6b0568ef8 100644
--- a/instrumentation/opentelemetry-instrumentation-django/tests/test_middleware.py
+++ b/instrumentation/opentelemetry-instrumentation-django/tests/test_middleware.py
@@ -392,6 +392,32 @@ def response_hook(span, request, response):
         self.assertIsInstance(response_hook_args[2], HttpResponse)
         self.assertEqual(response_hook_args[2], response)
 
+    def test_request_hook_exception(self):
+        def request_hook(span, request):
+            # pylint: disable=broad-exception-raised
+            raise Exception("request hook exception")
+
+        _DjangoMiddleware._otel_request_hook = request_hook
+        Client().get("/span_name/1234/")
+        _DjangoMiddleware._otel_request_hook = None
+
+        # ensure that span ended
+        finished_spans = self.memory_exporter.get_finished_spans()
+        self.assertEqual(len(finished_spans), 1)
+
+    def test_response_hook_exception(self):
+        def response_hook(span, request, response):
+            # pylint: disable=broad-exception-raised
+            raise Exception("response hook exception")
+
+        _DjangoMiddleware._otel_response_hook = response_hook
+        Client().get("/span_name/1234/")
+        _DjangoMiddleware._otel_response_hook = None
+
+        # ensure that span ended
+        finished_spans = self.memory_exporter.get_finished_spans()
+        self.assertEqual(len(finished_spans), 1)
+
     def test_trace_parent(self):
         id_generator = RandomIdGenerator()
         trace_id = format_trace_id(id_generator.generate_trace_id())