diff --git a/instrumentation/opentelemetry-instrumentation-kafka-python/src/opentelemetry/instrumentation/kafka/utils.py b/instrumentation/opentelemetry-instrumentation-kafka-python/src/opentelemetry/instrumentation/kafka/utils.py
index 3f9bd6f39c..f3250ff487 100644
--- a/instrumentation/opentelemetry-instrumentation-kafka-python/src/opentelemetry/instrumentation/kafka/utils.py
+++ b/instrumentation/opentelemetry-instrumentation-kafka-python/src/opentelemetry/instrumentation/kafka/utils.py
@@ -24,6 +24,14 @@ def _extract_argument(key, position, default_value, args, kwargs):
             return args[position]
         return kwargs.get(key, default_value)
 
+    @staticmethod
+    def has_headers_in_args(args):
+        return len(args) > 3
+
+    @staticmethod
+    def replace_headers_in_args(args, new_headers) -> tuple:
+        return *args[:3], new_headers, *args[4:]
+
     @staticmethod
     def extract_send_topic(args, kwargs):
         """extract topic from `send` method arguments in KafkaProducer class"""
@@ -143,7 +151,13 @@ def _traced_send(func, instance, args, kwargs):
         headers = KafkaPropertiesExtractor.extract_send_headers(args, kwargs)
         if headers is None:
             headers = []
-            kwargs["headers"] = headers
+
+            if KafkaPropertiesExtractor.has_headers_in_args(args):
+                args = KafkaPropertiesExtractor.replace_headers_in_args(
+                    args, headers
+                )
+            else:
+                kwargs["headers"] = headers
 
         topic = KafkaPropertiesExtractor.extract_send_topic(args, kwargs)
         bootstrap_servers = KafkaPropertiesExtractor.extract_bootstrap_servers(
diff --git a/instrumentation/opentelemetry-instrumentation-kafka-python/tests/test_instrumentation.py b/instrumentation/opentelemetry-instrumentation-kafka-python/tests/test_instrumentation.py
index 7bc724fb78..936a4fed1c 100644
--- a/instrumentation/opentelemetry-instrumentation-kafka-python/tests/test_instrumentation.py
+++ b/instrumentation/opentelemetry-instrumentation-kafka-python/tests/test_instrumentation.py
@@ -12,6 +12,9 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 from unittest import TestCase
+from unittest.mock import Mock, patch
+
+import kafka
 
 from kafka import KafkaConsumer, KafkaProducer
 from wrapt import BoundFunctionWrapper
@@ -34,3 +37,22 @@ def test_instrument_api(self) -> None:
         self.assertFalse(
             isinstance(KafkaConsumer.__next__, BoundFunctionWrapper)
         )
+
+    def test_kafka_producer_send_arguments(self) -> None:
+        instrumentation = KafkaInstrumentor()
+
+        class MockedKafkaProducer(Mock):
+            def send(self, topic, value=None, key=None, headers=None,
+                     partition=None, timestamp_ms=None):
+                pass
+
+        with patch.object(kafka, "KafkaProducer", MockedKafkaProducer):
+            instrumentation.instrument()
+            producer = kafka.KafkaProducer()
+            producer.send('test-topic', b'message')
+            producer.send('test-topic', b'message', None, None, None, None)
+            producer.send(
+                'test-topic', b'message', None,
+                headers=[("system", "amd64")]
+            )
+            instrumentation.uninstrument()