diff --git a/CHANGELOG.md b/CHANGELOG.md
index ee92bdab7a..40a03e5aca 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -7,6 +7,9 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 
 ## Unreleased
 
+- Add optional distro and configurator specification for auto-instrumentation
+  ([#1823](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/1823))
+
 ## Version 1.18.0/0.39b0 (2023-05-10)
 
 - `opentelemetry-instrumentation-system-metrics` Add `process.` prefix to `runtime.memory`, `runtime.cpu.time`, and `runtime.gc_count`. Change `runtime.memory` from count to UpDownCounter. ([#1735](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/1735))
diff --git a/opentelemetry-instrumentation/README.rst b/opentelemetry-instrumentation/README.rst
index 95b8fe582b..9788777034 100644
--- a/opentelemetry-instrumentation/README.rst
+++ b/opentelemetry-instrumentation/README.rst
@@ -18,12 +18,15 @@ This package provides a couple of commands that help automatically instruments a
 
 .. note::
     You need to install a distro package to get auto instrumentation working. The ``opentelemetry-distro``
-    package contains the default distro and automatically configures some of the common options for users.
+    package contains the default distro and configurator and automatically configures some of the common options for users.
     For more info about ``opentelemetry-distro`` check `here <https://opentelemetry-python.readthedocs.io/en/latest/examples/distro/README.html>`__
     ::
 
         pip install opentelemetry-distro[otlp]
 
+    When creating a custom distro and/or configurator, be sure to add entry points for each under opentelemetry_distro and opentelemetry_configurator respectfully.
+    If you have entry points for multiple distros or configurators present in your environment, you should specify the entry point name of the distro and configurator you want to be used via the OTEL_PYTHON_DISTRO and OTEL_PYTHON_CONFIGURATOR environment variables.
+
 
 opentelemetry-bootstrap
 -----------------------
@@ -58,6 +61,8 @@ The command supports the following configuration options as CLI arguments and en
 
 * ``--traces_exporter`` or ``OTEL_TRACES_EXPORTER``
 * ``--metrics_exporter`` or ``OTEL_METRICS_EXPORTER``
+* ``--distro`` or ``OTEL_PYTHON_DISTRO``
+* ``--configurator`` or ``OTEL_PYTHON_CONFIGURATOR``
 
 Used to specify which trace exporter to use. Can be set to one or more of the well-known exporter
 names (see below).
diff --git a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/sitecustomize.py b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/sitecustomize.py
index 9504e359af..c1ab42e493 100644
--- a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/sitecustomize.py
+++ b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/sitecustomize.py
@@ -23,7 +23,9 @@
 )
 from opentelemetry.instrumentation.distro import BaseDistro, DefaultDistro
 from opentelemetry.instrumentation.environment_variables import (
+    OTEL_PYTHON_CONFIGURATOR,
     OTEL_PYTHON_DISABLED_INSTRUMENTATIONS,
+    OTEL_PYTHON_DISTRO,
 )
 from opentelemetry.instrumentation.utils import _python_path_without_directory
 from opentelemetry.instrumentation.version import __version__
@@ -32,19 +34,28 @@
 
 
 def _load_distros() -> BaseDistro:
+    distro_name = environ.get(OTEL_PYTHON_DISTRO, None)
     for entry_point in iter_entry_points("opentelemetry_distro"):
         try:
-            distro = entry_point.load()()
-            if not isinstance(distro, BaseDistro):
+            if distro_name is None or distro_name == entry_point.name:
+                distro = entry_point.load()()
+                if not isinstance(distro, BaseDistro):
+                    logger.debug(
+                        "%s is not an OpenTelemetry Distro. Skipping",
+                        entry_point.name,
+                    )
+                    continue
                 logger.debug(
-                    "%s is not an OpenTelemetry Distro. Skipping",
+                    "Distribution %s will be configured", entry_point.name
+                )
+                return distro
+            else:
+                logger.warning(
+                    "%s distro not loaded because %s is set by %s",
                     entry_point.name,
+                    distro_name,
+                    OTEL_PYTHON_DISTRO,
                 )
-                continue
-            logger.debug(
-                "Distribution %s will be configured", entry_point.name
-            )
-            return distro
         except Exception as exc:  # pylint: disable=broad-except
             logger.exception(
                 "Distribution %s configuration failed", entry_point.name
@@ -92,6 +103,7 @@ def _load_instrumentors(distro):
 
 
 def _load_configurators():
+    configurator_name = environ.get(OTEL_PYTHON_CONFIGURATOR, None)
     configured = None
     for entry_point in iter_entry_points("opentelemetry_configurator"):
         if configured is not None:
@@ -102,8 +114,19 @@ def _load_configurators():
             )
             continue
         try:
-            entry_point.load()().configure(auto_instrumentation_version=__version__)  # type: ignore
-            configured = entry_point.name
+            if (
+                configurator_name is None
+                or configurator_name == entry_point.name
+            ):
+                entry_point.load()().configure(auto_instrumentation_version=__version__)  # type: ignore
+                configured = entry_point.name
+            else:
+                logger.warning(
+                    "Configuration of %s not loaded because %s is set by %s",
+                    entry_point.name,
+                    configurator_name,
+                    OTEL_PYTHON_CONFIGURATOR,
+                )
         except Exception as exc:  # pylint: disable=broad-except
             logger.exception("Configuration of %s failed", entry_point.name)
             raise exc
diff --git a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/environment_variables.py b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/environment_variables.py
index ad28f06859..7886779632 100644
--- a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/environment_variables.py
+++ b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/environment_variables.py
@@ -16,3 +16,13 @@
 """
 .. envvar:: OTEL_PYTHON_DISABLED_INSTRUMENTATIONS
 """
+
+OTEL_PYTHON_DISTRO = "OTEL_PYTHON_DISTRO"
+"""
+.. envvar:: OTEL_PYTHON_DISTRO
+"""
+
+OTEL_PYTHON_CONFIGURATOR = "OTEL_PYTHON_CONFIGURATOR"
+"""
+.. envvar:: OTEL_PYTHON_CONFIGURATOR
+"""