diff --git a/experimental/CHANGELOG.md b/experimental/CHANGELOG.md
index af55157906b..addacc8e62a 100644
--- a/experimental/CHANGELOG.md
+++ b/experimental/CHANGELOG.md
@@ -25,6 +25,7 @@ For notes on migrating to 2.x / 0.200.x see [the upgrade guide](doc/upgrade-to-2
 
 ### :bug: Bug Fixes
 
+* fix(otlp-exporter-base): use sendBeacon with empty headers [#6216](https://github.com/open-telemetry/opentelemetry-js/pull/6216) @YangJonghun
 * fix(instrumentation-grpc): attach correct name to diag message [#6097](https://github.com/open-telemetry/opentelemetry-js/pull/6043) @pichlermarc
 * fix(opentelemetry-sdk-node): default to otlp if OTEL_METRICS_EXPORTER is empty [#6092](https://github.com/open-telemetry/opentelemetry-js/pull/6092) @jeengbe
 * fix(configuration): merge service name from OTEL_SERVICE_NAME instead of replacing all resource attributes [#6162](https://github.com/open-telemetry/opentelemetry-js/pull/6162) @maryliag
diff --git a/experimental/packages/otlp-exporter-base/src/configuration/create-legacy-browser-delegate.ts b/experimental/packages/otlp-exporter-base/src/configuration/create-legacy-browser-delegate.ts
index b1c3823e235..cd80b7614ff 100644
--- a/experimental/packages/otlp-exporter-base/src/configuration/create-legacy-browser-delegate.ts
+++ b/experimental/packages/otlp-exporter-base/src/configuration/create-legacy-browser-delegate.ts
@@ -50,7 +50,12 @@ export function createLegacyOtlpBrowserExportDelegate<Internal, Response>(
 export function inferExportDelegateToUse(
   configHeaders: OTLPExporterConfigBase['headers']
 ) {
-  if (!configHeaders && typeof navigator.sendBeacon === 'function') {
+  const isEmptyHeaders =
+    configHeaders == null ||
+    (typeof configHeaders === 'object' &&
+      Object.keys(configHeaders).length === 0);
+
+  if (isEmptyHeaders && typeof navigator.sendBeacon === 'function') {
     return createOtlpSendBeaconExportDelegate;
   } else if (typeof globalThis.fetch !== 'undefined') {
     return createOtlpFetchExportDelegate;
diff --git a/experimental/packages/otlp-exporter-base/test/browser/create-legacy-browser-delegate.test.ts b/experimental/packages/otlp-exporter-base/test/browser/create-legacy-browser-delegate.test.ts
index ff0fe985acb..5d3a9a10aa0 100644
--- a/experimental/packages/otlp-exporter-base/test/browser/create-legacy-browser-delegate.test.ts
+++ b/experimental/packages/otlp-exporter-base/test/browser/create-legacy-browser-delegate.test.ts
@@ -29,6 +29,11 @@ describe('createLegacyBrowserDelegate', function () {
       assert.equal(delegate, createOtlpSendBeaconExportDelegate);
     });
 
+    it('uses the beacon delegate when headers is empty object', function () {
+      const delegate = inferExportDelegateToUse({});
+      assert.equal(delegate, createOtlpSendBeaconExportDelegate);
+    });
+
     it('uses the fetch delegate when headers are provided', function () {
       const delegate = inferExportDelegateToUse({ foo: 'bar' });
       assert.equal(delegate, createOtlpFetchExportDelegate);