diff --git a/experimental/packages/opentelemetry-instrumentation-http/README.md b/experimental/packages/opentelemetry-instrumentation-http/README.md
index 340d658b241..85579bcac15 100644
--- a/experimental/packages/opentelemetry-instrumentation-http/README.md
+++ b/experimental/packages/opentelemetry-instrumentation-http/README.md
@@ -51,7 +51,9 @@ Http instrumentation has few options available to choose from. You can set the f
 | [`startIncomingSpanHook`](https://github.com/open-telemetry/opentelemetry-js/blob/main/experimental/packages/opentelemetry-instrumentation-http/src/types.ts#L97) | `StartIncomingSpanCustomAttributeFunction` | Function for adding custom attributes before a span is started in incomingRequest |
 | [`startOutgoingSpanHook`](https://github.com/open-telemetry/opentelemetry-js/blob/main/experimental/packages/opentelemetry-instrumentation-http/src/types.ts#L99) | `StartOutgoingSpanCustomAttributeFunction` | Function for adding custom attributes before a span is started in outgoingRequest |
 | [`ignoreIncomingPaths`](https://github.com/open-telemetry/opentelemetry-js/blob/main/experimental/packages/opentelemetry-instrumentation-http/src/types.ts#L87) | `IgnoreMatcher[]` | Http instrumentation will not trace all incoming requests that match paths |
+| `ignoreIncomingRequestHook` | `IgnoreIncomingRequestFunction[]` | Http instrumentation will not trace all incoming requests that matched with custom function |
 | [`ignoreOutgoingUrls`](https://github.com/open-telemetry/opentelemetry-js/blob/main/experimental/packages/opentelemetry-instrumentation-http/src/types.ts#L89) | `IgnoreMatcher[]` | Http instrumentation will not trace all outgoing requests that match urls |
+| `ignoreOutgoingRequestHook` | `IgnoreOutgoingRequestFunction[]` | Http instrumentation will not trace all outgoing requests that matched with custom function |
 | [`serverName`](https://github.com/open-telemetry/opentelemetry-js/blob/main/experimental/packages/opentelemetry-instrumentation-http/src/types.ts#L101) | `string` | The primary server name of the matched virtual host. |
 | [`requireParentforOutgoingSpans`](https://github.com/open-telemetry/opentelemetry-js/blob/main/experimental/packages/opentelemetry-instrumentation-http/src/types.ts#L103) | Boolean | Require that is a parent span to create new span for outgoing requests. |
 | [`requireParentforIncomingSpans`](https://github.com/open-telemetry/opentelemetry-js/blob/main/experimental/packages/opentelemetry-instrumentation-http/src/types.ts#L105) | Boolean | Require that is a parent span to create new span for incoming requests. |
diff --git a/experimental/packages/opentelemetry-instrumentation-http/src/http.ts b/experimental/packages/opentelemetry-instrumentation-http/src/http.ts
index e183d5e5e65..23477b5340e 100644
--- a/experimental/packages/opentelemetry-instrumentation-http/src/http.ts
+++ b/experimental/packages/opentelemetry-instrumentation-http/src/http.ts
@@ -382,7 +382,12 @@ export class HttpInstrumentation extends InstrumentationBase<Http> {
         utils.isIgnored(
           pathname,
           instrumentation._getConfig().ignoreIncomingPaths,
-          (e: Error) => instrumentation._diag.error('caught ignoreIncomingPaths error: ', e)
+          (e: unknown) => instrumentation._diag.error('caught ignoreIncomingPaths error: ', e)
+        ) ||
+        safeExecuteInTheMiddle(
+          () => instrumentation._getConfig().ignoreIncomingRequestHook?.(request),
+          () => {},
+          true
         )
       ) {
         return context.with(suppressTracing(context.active()), () => {
@@ -534,7 +539,12 @@ export class HttpInstrumentation extends InstrumentationBase<Http> {
         utils.isIgnored(
           origin + pathname,
           instrumentation._getConfig().ignoreOutgoingUrls,
-          (e: Error) => instrumentation._diag.error('caught ignoreOutgoingUrls error: ', e)
+          (e: unknown) => instrumentation._diag.error('caught ignoreOutgoingUrls error: ', e)
+        ) ||
+        safeExecuteInTheMiddle(
+          () => instrumentation._getConfig().ignoreOutgoingRequestHook?.(optionsParsed),
+          () => {},
+          true
         )
       ) {
         return original.apply(this, [optionsParsed, ...args]);
diff --git a/experimental/packages/opentelemetry-instrumentation-http/src/types.ts b/experimental/packages/opentelemetry-instrumentation-http/src/types.ts
index 79f4e844cd2..fdb26147fce 100644
--- a/experimental/packages/opentelemetry-instrumentation-http/src/types.ts
+++ b/experimental/packages/opentelemetry-instrumentation-http/src/types.ts
@@ -13,7 +13,7 @@
  * See the License for the specific language governing permissions and
  * limitations under the License.
  */
-import { 
+import {
   Span,
   SpanAttributes,
  } from '@opentelemetry/api';
@@ -63,6 +63,14 @@ export interface HttpCustomAttributeFunction {
   ): void;
 }
 
+export interface IgnoreIncomingRequestFunction {
+  (request: IncomingMessage ): boolean;
+}
+
+export interface IgnoreOutgoingRequestFunction {
+  (request: RequestOptions ): boolean;
+}
+
 export interface HttpRequestCustomAttributeFunction {
   (span: Span, request: ClientRequest | IncomingMessage): void;
 }
@@ -85,8 +93,12 @@ export interface StartOutgoingSpanCustomAttributeFunction {
 export interface HttpInstrumentationConfig extends InstrumentationConfig {
   /** Not trace all incoming requests that match paths */
   ignoreIncomingPaths?: IgnoreMatcher[];
+  /** Not trace all incoming requests that matched with custom function */
+  ignoreIncomingRequestHook?: IgnoreIncomingRequestFunction;
   /** Not trace all outgoing requests that match urls */
   ignoreOutgoingUrls?: IgnoreMatcher[];
+  /** Not trace all outgoing requests that matched with custom function */
+  ignoreOutgoingRequestHook?: IgnoreOutgoingRequestFunction;
   /** Function for adding custom attributes after response is handled */
   applyCustomAttributesOnSpan?: HttpCustomAttributeFunction;
   /** Function for adding custom attributes before request is handled */
diff --git a/experimental/packages/opentelemetry-instrumentation-http/src/utils.ts b/experimental/packages/opentelemetry-instrumentation-http/src/utils.ts
index 4f8a03c7af8..e1393b242f4 100644
--- a/experimental/packages/opentelemetry-instrumentation-http/src/utils.ts
+++ b/experimental/packages/opentelemetry-instrumentation-http/src/utils.ts
@@ -129,7 +129,7 @@ export const satisfiesPattern = (
 export const isIgnored = (
   constant: string,
   list?: IgnoreMatcher[],
-  onException?: (error: Error) => void
+  onException?: (error: unknown) => void
 ): boolean => {
   if (!list) {
     // No ignored urls - trace everything
@@ -304,18 +304,18 @@ export const getRequestInfo = (
     }`;
   }
 
-  if (hasExpectHeader(optionsParsed)) {
-    optionsParsed.headers = Object.assign({}, optionsParsed.headers);
-  } else if (!optionsParsed.headers) {
-    optionsParsed.headers = {};
-  }
+  const headers = optionsParsed.headers ?? {};
+  optionsParsed.headers = Object.keys(headers).reduce((normalizedHeader, key) => {
+    normalizedHeader[key.toLowerCase()] = headers[key];
+    return normalizedHeader;
+  }, {} as OutgoingHttpHeaders);
   // some packages return method in lowercase..
   // ensure upperCase for consistency
   const method = optionsParsed.method
     ? optionsParsed.method.toUpperCase()
     : 'GET';
 
-  return { origin, pathname, method, optionsParsed };
+  return { origin, pathname, method, optionsParsed, };
 };
 
 /**
@@ -501,7 +501,7 @@ export function headerCapture(type: 'request' | 'response', headers: string[]) {
   return (span: Span, getHeader: (key: string) => undefined | string | string[] | number) => {
     for (const [capturedHeader, normalizedHeader] of normalizedHeaders) {
       const value = getHeader(capturedHeader);
-      
+
       if (value === undefined) {
         continue;
       }
diff --git a/experimental/packages/opentelemetry-instrumentation-http/test/functionals/http-enable.test.ts b/experimental/packages/opentelemetry-instrumentation-http/test/functionals/http-enable.test.ts
index 72c1ca5a1f7..38c549b7e39 100644
--- a/experimental/packages/opentelemetry-instrumentation-http/test/functionals/http-enable.test.ts
+++ b/experimental/packages/opentelemetry-instrumentation-http/test/functionals/http-enable.test.ts
@@ -18,7 +18,7 @@ import {
   context,
   propagation,
   Span as ISpan,
-  SpanKind, 
+  SpanKind,
   trace,
   SpanAttributes,
 } from '@opentelemetry/api';
@@ -142,11 +142,17 @@ describe('HttpInstrumentation', () => {
               throw new Error('bad ignoreIncomingPaths function');
             },
           ],
+          ignoreIncomingRequestHook: _request => {
+            throw new Error('bad ignoreIncomingRequestHook function');
+          },
           ignoreOutgoingUrls: [
             (url: string) => {
               throw new Error('bad ignoreOutgoingUrls function');
             },
           ],
+          ignoreOutgoingRequestHook: _request => {
+            throw new Error('bad ignoreOutgoingRequestHook function');
+          },
           applyCustomAttributesOnSpan: () => {
             throw new Error(applyCustomAttributesOnSpanErrorMessage);
           },
@@ -167,7 +173,12 @@ describe('HttpInstrumentation', () => {
 
       it('should generate valid spans (client side and server side)', async () => {
         const result = await httpRequest.get(
-          `${protocol}://${hostname}:${serverPort}${pathname}`
+          `${protocol}://${hostname}:${serverPort}${pathname}`,
+          {
+            headers: {
+              'user-agent': 'tester'
+            }
+          }
         );
         const spans = memoryExporter.getFinishedSpans();
         const [incomingSpan, outgoingSpan] = spans;
@@ -207,11 +218,20 @@ describe('HttpInstrumentation', () => {
             /\/ignored\/regexp$/i,
             (url: string) => url.endsWith('/ignored/function'),
           ],
+          ignoreIncomingRequestHook: request => {
+            return request.headers['user-agent']?.match('ignored-string') != null;
+          },
           ignoreOutgoingUrls: [
             `${protocol}://${hostname}:${serverPort}/ignored/string`,
             /\/ignored\/regexp$/i,
             (url: string) => url.endsWith('/ignored/function'),
           ],
+          ignoreOutgoingRequestHook: request => {
+            if (request.headers?.['user-agent'] != null) {
+              return `${request.headers['user-agent']}`.match('ignored-string') != null;
+            }
+            return false;
+          },
           applyCustomAttributesOnSpan: customAttributeFunction,
           requestHook: requestHookFunction,
           responseHook: responseHookFunction,
@@ -447,7 +467,7 @@ describe('HttpInstrumentation', () => {
       });
 
       for (const ignored of ['string', 'function', 'regexp']) {
-        it(`should not trace ignored requests (client and server side) with type ${ignored}`, async () => {
+        it(`should not trace ignored requests with paths (client and server side) with type ${ignored}`, async () => {
           const testPath = `/ignored/${ignored}`;
 
           await httpRequest.get(
@@ -458,6 +478,31 @@ describe('HttpInstrumentation', () => {
         });
       }
 
+      it('should not trace ignored requests with headers (client and server side)', async () => {
+        const testValue = 'ignored-string';
+
+        await Promise.all([
+          httpRequest.get(
+            `${protocol}://${hostname}:${serverPort}`,
+            {
+              headers: {
+                'user-agent': testValue
+              }
+            }
+          ),
+          httpRequest.get(
+            `${protocol}://${hostname}:${serverPort}`,
+            {
+              headers: {
+                'uSeR-aGeNt': testValue
+              }
+            }
+          )
+        ]);
+        const spans = memoryExporter.getFinishedSpans();
+        assert.strictEqual(spans.length, 0);
+      });
+
       for (const arg of ['string', {}, new Date()]) {
         it(`should be tracable and not throw exception in ${protocol} instrumentation when passing the following argument ${JSON.stringify(
           arg
@@ -507,7 +552,7 @@ describe('HttpInstrumentation', () => {
             hostname: 'localhost',
             pathname: '/',
             forceStatus: {
-              code: SpanStatusCode.ERROR, 
+              code: SpanStatusCode.ERROR,
               message: err.message,
             },
             component: 'http',
diff --git a/experimental/packages/opentelemetry-instrumentation-http/test/functionals/https-enable.test.ts b/experimental/packages/opentelemetry-instrumentation-http/test/functionals/https-enable.test.ts
index 46bf516e136..2611642b4c0 100644
--- a/experimental/packages/opentelemetry-instrumentation-http/test/functionals/https-enable.test.ts
+++ b/experimental/packages/opentelemetry-instrumentation-http/test/functionals/https-enable.test.ts
@@ -112,11 +112,17 @@ describe('HttpsInstrumentation', () => {
               throw new Error('bad ignoreIncomingPaths function');
             },
           ],
+          ignoreIncomingRequestHook: _request => {
+            throw new Error('bad ignoreIncomingRequestHook function');
+          },
           ignoreOutgoingUrls: [
             (url: string) => {
               throw new Error('bad ignoreOutgoingUrls function');
             },
           ],
+          ignoreOutgoingRequestHook: _request => {
+            throw new Error('bad ignoreOutgoingRequestHook function');
+          },
           applyCustomAttributesOnSpan: () => {
             throw new Error(applyCustomAttributesOnSpanErrorMessage);
           },
@@ -142,7 +148,12 @@ describe('HttpsInstrumentation', () => {
 
       it('should generate valid spans (client side and server side)', async () => {
         const result = await httpsRequest.get(
-          `${protocol}://${hostname}:${serverPort}${pathname}`
+          `${protocol}://${hostname}:${serverPort}${pathname}`,
+          {
+            headers: {
+              'user-agent': 'tester'
+            }
+          }
         );
         const spans = memoryExporter.getFinishedSpans();
         const [incomingSpan, outgoingSpan] = spans;
@@ -181,11 +192,20 @@ describe('HttpsInstrumentation', () => {
             /\/ignored\/regexp$/i,
             (url: string) => url.endsWith('/ignored/function'),
           ],
+          ignoreIncomingRequestHook: request => {
+            return request.headers['user-agent']?.match('ignored-string') != null;
+          },
           ignoreOutgoingUrls: [
             `${protocol}://${hostname}:${serverPort}/ignored/string`,
             /\/ignored\/regexp$/i,
             (url: string) => url.endsWith('/ignored/function'),
           ],
+          ignoreOutgoingRequestHook: request => {
+            if (request.headers?.['user-agent'] != null) {
+              return `${request.headers['user-agent']}`.match('ignored-string') != null;
+            }
+            return false;
+          },
           applyCustomAttributesOnSpan: customAttributeFunction,
           serverName,
         });
@@ -412,7 +432,7 @@ describe('HttpsInstrumentation', () => {
       });
 
       for (const ignored of ['string', 'function', 'regexp']) {
-        it(`should not trace ignored requests (client and server side) with type ${ignored}`, async () => {
+        it(`should not trace ignored requests with paths (client and server side) with type ${ignored}`, async () => {
           const testPath = `/ignored/${ignored}`;
 
           await httpsRequest.get(
@@ -423,6 +443,31 @@ describe('HttpsInstrumentation', () => {
         });
       }
 
+      it('should not trace ignored requests with headers (client and server side)', async () => {
+        const testValue = 'ignored-string';
+
+        await Promise.all([
+          httpsRequest.get(
+            `${protocol}://${hostname}:${serverPort}`,
+            {
+              headers: {
+                'user-agent': testValue
+              }
+            }
+          ),
+          httpsRequest.get(
+            `${protocol}://${hostname}:${serverPort}`,
+            {
+              headers: {
+                'uSeR-aGeNt': testValue
+              }
+            }
+          )
+        ]);
+        const spans = memoryExporter.getFinishedSpans();
+        assert.strictEqual(spans.length, 0);
+      });
+
       for (const arg of ['string', {}, new Date()]) {
         it(`should be tracable and not throw exception in ${protocol} instrumentation when passing the following argument ${JSON.stringify(
           arg
diff --git a/experimental/packages/opentelemetry-instrumentation-http/test/functionals/utils.test.ts b/experimental/packages/opentelemetry-instrumentation-http/test/functionals/utils.test.ts
index 7b8a2e8d1ef..35e68f4211c 100644
--- a/experimental/packages/opentelemetry-instrumentation-http/test/functionals/utils.test.ts
+++ b/experimental/packages/opentelemetry-instrumentation-http/test/functionals/utils.test.ts
@@ -170,7 +170,7 @@ describe('Utility', () => {
     });
 
     it('should not re-throw when function throws an exception', () => {
-      const onException = (e: Error) => {
+      const onException = (e: unknown) => {
         // Do nothing
       };
       for (const callback of [undefined, onException]) {
@@ -480,7 +480,7 @@ describe('Utility', () => {
       assert.strictEqual(attributes[SemanticAttributes.HTTP_ROUTE], undefined)
     });
   });
-  
+
   describe('headers to span attributes capture', () => {
     let span: Span;