diff --git a/CHANGELOG.md b/CHANGELOG.md
index 6b8a48f28c..6f35743c4c 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -42,6 +42,7 @@ OpenTelemetry Go Automatic Instrumentation adheres to [Semantic Versioning](http
 - Cache offsets for Go `1.26.0`. ([#3303](https://github.com/open-telemetry/opentelemetry-go-instrumentation/pull/3303))
 - Cache offsets for `google.golang.org/grpc` `1.79.1`. ([#3319](https://github.com/open-telemetry/opentelemetry-go-instrumentation/pull/3319))
 - Cache offsets for `golang.org/x/net` `0.51.0`. ([#3351](https://github.com/open-telemetry/opentelemetry-go-instrumentation/pull/3351))
+- Cache offsets for `go.opentelemetry.io/otel` `v1.41.0`. ([#3361](https://github.com/open-telemetry/opentelemetry-go-instrumentation/pull/3361))
 
 ### Removed
 
diff --git a/COMPATIBILITY.md b/COMPATIBILITY.md
index e86e9db906..16c2b1bf14 100644
--- a/COMPATIBILITY.md
+++ b/COMPATIBILITY.md
@@ -7,7 +7,7 @@ Auto-instrumentation can be configured to capture the telemetry sent to the
 
 Supported versions of [`otel`]:
 
-- `v0.14.0` to `v1.39.0`
+- `v0.14.0` to `v1.41.0`
 
 **Note**: Versions of `go.opentelemetry.io/otel < v1.33.0` are not supported
 when using Go >= `1.24`. See [this issue] for details.
diff --git a/internal/pkg/inject/offset_results.json b/internal/pkg/inject/offset_results.json
index 03ef532187..9041121d9d 100644
--- a/internal/pkg/inject/offset_results.json
+++ b/internal/pkg/inject/offset_results.json
@@ -979,7 +979,8 @@
                       "1.37.0",
                       "1.38.0",
                       "1.39.0",
-                      "1.40.0"
+                      "1.40.0",
+                      "1.41.0"
                     ]
                   }
                 ]
@@ -1085,7 +1086,8 @@
                       "1.37.0",
                       "1.38.0",
                       "1.39.0",
-                      "1.40.0"
+                      "1.40.0",
+                      "1.41.0"
                     ]
                   }
                 ]
@@ -1191,7 +1193,8 @@
                       "1.37.0",
                       "1.38.0",
                       "1.39.0",
-                      "1.40.0"
+                      "1.40.0",
+                      "1.41.0"
                     ]
                   }
                 ]
@@ -1302,7 +1305,8 @@
                       "1.37.0",
                       "1.38.0",
                       "1.39.0",
-                      "1.40.0"
+                      "1.40.0",
+                      "1.41.0"
                     ]
                   }
                 ]
@@ -1413,7 +1417,8 @@
                       "1.37.0",
                       "1.38.0",
                       "1.39.0",
-                      "1.40.0"
+                      "1.40.0",
+                      "1.41.0"
                     ]
                   }
                 ]
@@ -1514,7 +1519,8 @@
                       "1.37.0",
                       "1.38.0",
                       "1.39.0",
-                      "1.40.0"
+                      "1.40.0",
+                      "1.41.0"
                     ]
                   }
                 ]
@@ -1615,7 +1621,8 @@
                       "1.37.0",
                       "1.38.0",
                       "1.39.0",
-                      "1.40.0"
+                      "1.40.0",
+                      "1.41.0"
                     ]
                   }
                 ]