diff --git a/interpreter/go/go.go b/interpreter/go/go.go
index 0cde865dc..ff5d54fbf 100644
--- a/interpreter/go/go.go
+++ b/interpreter/go/go.go
@@ -7,6 +7,7 @@ import (
 	"fmt"
 	"sync/atomic"
 
+	"go.opentelemetry.io/ebpf-profiler/host"
 	"go.opentelemetry.io/ebpf-profiler/interpreter"
 	"go.opentelemetry.io/ebpf-profiler/libpf"
 	"go.opentelemetry.io/ebpf-profiler/metrics"
@@ -24,6 +25,7 @@ var (
 type goData struct {
 	refs atomic.Int32
 
+	fileID  host.FileID
 	version string
 
 	pclntab *elfunwindinfo.Gopclntab
@@ -56,6 +58,7 @@ func Loader(_ interpreter.EbpfHandler, info *interpreter.LoaderInfo) (
 	}
 
 	g := &goData{
+		fileID:  info.FileID(),
 		version: goVersion,
 		pclntab: pclntab,
 	}
@@ -105,6 +108,10 @@ func (g *goInstance) Symbolize(ef libpf.EbpfFrame, frames *libpf.Frames, mapping
 	if !ef.Type().IsInterpType(libpf.Native) {
 		return interpreter.ErrMismatchInterpreterType
 	}
+	// Skip native frames that do not belong to this Go binary.
+	if host.FileID(ef.Variable(0)) != g.d.fileID {
+		return interpreter.ErrMismatchInterpreterType
+	}
 
 	sfCounter := successfailurecounter.New(&g.successCount, &g.failCount)
 	defer sfCounter.DefaultToFailure()
diff --git a/processmanager/manager_test.go b/processmanager/manager_test.go
new file mode 100644
index 000000000..0be3c7c19
--- /dev/null
+++ b/processmanager/manager_test.go
@@ -0,0 +1,157 @@
+package processmanager
+
+import (
+	"os"
+	"runtime"
+	"slices"
+	"testing"
+
+	lru "github.com/elastic/go-freelru"
+	"github.com/stretchr/testify/assert"
+	"github.com/stretchr/testify/require"
+
+	"go.opentelemetry.io/ebpf-profiler/host"
+	"go.opentelemetry.io/ebpf-profiler/interpreter"
+	golang "go.opentelemetry.io/ebpf-profiler/interpreter/go"
+	"go.opentelemetry.io/ebpf-profiler/libpf"
+	"go.opentelemetry.io/ebpf-profiler/libpf/pfelf"
+	"go.opentelemetry.io/ebpf-profiler/process"
+	"go.opentelemetry.io/ebpf-profiler/remotememory"
+	"go.opentelemetry.io/ebpf-profiler/reporter/samples"
+	"go.opentelemetry.io/ebpf-profiler/util"
+)
+
+type traceCapture struct {
+	traces []*libpf.Trace
+}
+
+func (tc *traceCapture) ReportTraceEvent(trace *libpf.Trace, _ *samples.TraceEventMeta) error {
+	tc.traces = append(tc.traces, trace)
+	return nil
+}
+
+func TestFrameCacheCrossProcessPollution(t *testing.T) {
+	require := require.New(t)
+
+	exec, err := os.Executable()
+	require.NoError(err)
+
+	pc, _, _, ok := runtime.Caller(0)
+	require.True(ok)
+
+	goPID := libpf.PID(1000)
+	catPID := libpf.PID(2000)
+
+	goHostFileID, err := host.FileIDFromBytes(
+		[]byte{0xAA, 0x55, 0xAA, 0x55, 0xAA, 0x55, 0xAA, 0x55})
+	require.NoError(err)
+	catHostFileID, err := host.FileIDFromBytes(
+		[]byte{0xCA, 0x7C, 0xA7, 0xCA, 0x7C, 0xA7, 0xCA, 0x7C})
+	require.NoError(err)
+	libcHostFileID, err := host.FileIDFromBytes(
+		[]byte{0xDE, 0xAD, 0xBE, 0xEF, 0xCA, 0xFE, 0xBA, 0xBE})
+	require.NoError(err)
+
+	realPID := libpf.PID(os.Getpid())
+	pid := process.New(realPID, realPID)
+	elfRef := pfelf.NewReference(exec, pid)
+	loaderInfo := interpreter.NewLoaderInfo(goHostFileID, elfRef)
+	rm := remotememory.NewProcessVirtualMemory(realPID)
+
+	goData, err := golang.Loader(nil, loaderInfo)
+	require.NoError(err)
+	goInstance, err := goData.Attach(nil, realPID, 0x0, rm)
+	require.NoError(err)
+
+	goODID := util.OnDiskFileIdentifier{DeviceID: 1, InodeNum: 1}
+
+	frameCache, err := lru.New[frameCacheKey, libpf.Frames](1024, hashFrameCacheKey)
+	require.NoError(err)
+	frameCache.SetLifetime(frameCacheLifetime)
+
+	goMappings := []Mapping{
+		{FrameMapping: libpf.NewFrameMapping(libpf.FrameMappingData{
+			File: libpf.NewFrameMappingFile(libpf.FrameMappingFileData{
+				FileID:   libpf.NewFileID(uint64(goHostFileID), 0),
+				FileName: libpf.Intern("go-binary"),
+			}),
+			Start: 0,
+			End:   0xFFFFFFF,
+		})},
+		{FrameMapping: libpf.NewFrameMapping(libpf.FrameMappingData{
+			File: libpf.NewFrameMappingFile(libpf.FrameMappingFileData{
+				FileID:   libpf.NewFileID(uint64(libcHostFileID), 0),
+				FileName: libpf.Intern("libc.so.6"),
+			}),
+			Start: 0,
+			End:   0xFFFFFFF,
+		})},
+	}
+	slices.SortFunc(goMappings, compareMapping)
+
+	catMappings := []Mapping{
+		{FrameMapping: libpf.NewFrameMapping(libpf.FrameMappingData{
+			File: libpf.NewFrameMappingFile(libpf.FrameMappingFileData{
+				FileID:   libpf.NewFileID(uint64(catHostFileID), 0),
+				FileName: libpf.Intern("cat"),
+			}),
+			Start: 0,
+			End:   0xFFFFFFF,
+		})},
+		{FrameMapping: libpf.NewFrameMapping(libpf.FrameMappingData{
+			File: libpf.NewFrameMappingFile(libpf.FrameMappingFileData{
+				FileID:   libpf.NewFileID(uint64(libcHostFileID), 0),
+				FileName: libpf.Intern("libc.so.6"),
+			}),
+			Start: 0,
+			End:   0xFFFFFFF,
+		})},
+	}
+	slices.SortFunc(catMappings, compareMapping)
+
+	capture := &traceCapture{}
+	pm := &ProcessManager{
+		interpreters: map[libpf.PID]map[util.OnDiskFileIdentifier]interpreter.Instance{
+			goPID: {goODID: goInstance},
+		},
+		pidToProcessInfo: map[libpf.PID]*processInfo{
+			goPID:  {mappings: goMappings},
+			catPID: {mappings: catMappings},
+		},
+		frameCache:    frameCache,
+		traceReporter: capture,
+	}
+
+	libcFrame := libpf.NewEbpfFrame(libpf.NativeFrame, 0, 2, uint64(pc))
+	libcFrame[1] = uint64(libcHostFileID)
+
+	pm.HandleTrace(&libpf.EbpfTrace{
+		PID:       goPID,
+		TID:       goPID,
+		NumFrames: 1,
+		FrameData: libcFrame,
+	})
+
+	require.Len(capture.traces, 1)
+	goTrace := capture.traces[0]
+	require.NotEmpty(goTrace.Frames)
+
+	goFrame := goTrace.Frames[0].Value()
+	assert.Equal(t, libpf.NativeFrame, goFrame.Type)
+	assert.Equal(t, "", goFrame.FunctionName.String())
+
+	pm.HandleTrace(&libpf.EbpfTrace{
+		PID:       catPID,
+		TID:       catPID,
+		NumFrames: 1,
+		FrameData: libcFrame,
+	})
+
+	require.Len(capture.traces, 2)
+	catTrace := capture.traces[1]
+	require.NotEmpty(catTrace.Frames)
+
+	catFrame := catTrace.Frames[0].Value()
+	assert.Equal(t, libpf.NativeFrame, catFrame.Type)
+	assert.Equal(t, "", catFrame.FunctionName.String())
+}