diff --git a/receiver/prometheusreceiver/internal/starttimemetricadjuster_test.go b/receiver/prometheusreceiver/internal/starttimemetricadjuster_test.go
index 91f0d7f060e68..fa90c6083a320 100644
--- a/receiver/prometheusreceiver/internal/starttimemetricadjuster_test.go
+++ b/receiver/prometheusreceiver/internal/starttimemetricadjuster_test.go
@@ -18,6 +18,7 @@ import (
 )
 
 func TestStartTimeMetricMatch(t *testing.T) {
+	t.Skip("Skipping test since it is flaky; see https://github.com/open-telemetry/opentelemetry-collector-contrib/issues/42684.")
 	const startTime = pcommon.Timestamp(123 * 1e9)
 	const currentTime = pcommon.Timestamp(126 * 1e9)
 	const matchBuilderStartTime = 124
diff --git a/receiver/prometheusreceiver/metrics_receiver_test.go b/receiver/prometheusreceiver/metrics_receiver_test.go
index f3439f1ee9efc..a0b892b69b657 100644
--- a/receiver/prometheusreceiver/metrics_receiver_test.go
+++ b/receiver/prometheusreceiver/metrics_receiver_test.go
@@ -1585,6 +1585,7 @@ example_process_start_time_seconds 400.8
 
 // TestStartTimeMetricRegex validates that timeseries have start time regex set to 'process_start_time_seconds'
 func TestStartTimeMetricRegex(t *testing.T) {
+	t.Skip("Skipping test since it is flaky, see https://github.com/open-telemetry/opentelemetry-collector-contrib/issues/42684.")
 	targets := []*testData{
 		{
 			name: "target1",