diff --git a/packages/babel-plugin-transform-es2015-classes/src/loose.js b/packages/babel-plugin-transform-es2015-classes/src/loose.js
index 953a8a23228fe..a47ece74c734e 100644
--- a/packages/babel-plugin-transform-es2015-classes/src/loose.js
+++ b/packages/babel-plugin-transform-es2015-classes/src/loose.js
@@ -8,13 +8,32 @@ export default class LooseClassTransformer extends VanillaTransformer {
     this.isLoose = true;
   }
 
+  _insertProtoAliasOnce() {
+    if (!this.methodAlias) {
+      this.methodAlias = this.path.scope.generateUidIdentifier("proto");
+      const classProto = t.memberExpression(
+        this.classRef,
+        t.identifier("prototype"),
+      );
+      const protoDeclaration = t.variableDeclaration("var", [
+        t.variableDeclarator(this.methodAlias, classProto),
+      ]);
+
+      this.body.push(protoDeclaration);
+      this.aliasInserted = true;
+      return true;
+    }
+    return false;
+  }
+
   _processMethod(node, scope) {
     if (!node.decorators) {
       // use assignments instead of define properties for loose classes
 
       let classRef = this.classRef;
       if (!node.static) {
-        classRef = t.memberExpression(classRef, t.identifier("prototype"));
+        this._insertProtoAliasOnce();
+        classRef = this.methodAlias;
       }
       const methodName = t.memberExpression(
         classRef,
diff --git a/packages/babel-plugin-transform-es2015-classes/test/fixtures/loose-classCallCheck/with-constructor/expected.js b/packages/babel-plugin-transform-es2015-classes/test/fixtures/loose-classCallCheck/with-constructor/expected.js
index e0e9ee4b8572f..f10ac140ad9d1 100644
--- a/packages/babel-plugin-transform-es2015-classes/test/fixtures/loose-classCallCheck/with-constructor/expected.js
+++ b/packages/babel-plugin-transform-es2015-classes/test/fixtures/loose-classCallCheck/with-constructor/expected.js
@@ -5,7 +5,9 @@ let A = function A() {
 let B = function () {
   function B() {}
 
-  B.prototype.b = function b() {
+  var _proto = B.prototype;
+
+  _proto.b = function b() {
     console.log('b');
   };
 
diff --git a/packages/babel-plugin-transform-es2015-classes/test/fixtures/loose/constructor-order/expected.js b/packages/babel-plugin-transform-es2015-classes/test/fixtures/loose/constructor-order/expected.js
index 633459e7b28fc..065b90daf3de5 100644
--- a/packages/babel-plugin-transform-es2015-classes/test/fixtures/loose/constructor-order/expected.js
+++ b/packages/babel-plugin-transform-es2015-classes/test/fixtures/loose/constructor-order/expected.js
@@ -1,5 +1,7 @@
 var x = function () {
-  x.prototype.f = function f() {
+  var _proto = x.prototype;
+
+  _proto.f = function f() {
     1;
     2;
     3;
diff --git a/packages/babel-plugin-transform-es2015-classes/test/fixtures/loose/literal-key/expected.js b/packages/babel-plugin-transform-es2015-classes/test/fixtures/loose/literal-key/expected.js
index 126cb3ecded66..1bb06b9c2871a 100644
--- a/packages/babel-plugin-transform-es2015-classes/test/fixtures/loose/literal-key/expected.js
+++ b/packages/babel-plugin-transform-es2015-classes/test/fixtures/loose/literal-key/expected.js
@@ -1,7 +1,9 @@
 var Foo = function () {
   function Foo() {}
 
-  Foo.prototype["bar"] = function bar() {};
+  var _proto = Foo.prototype;
+
+  _proto["bar"] = function bar() {};
 
   return Foo;
-}();
+}();
\ No newline at end of file
diff --git a/packages/babel-plugin-transform-es2015-classes/test/fixtures/loose/method-return-type-annotation/expected.js b/packages/babel-plugin-transform-es2015-classes/test/fixtures/loose/method-return-type-annotation/expected.js
index 513dccbcdf3a4..950273999984f 100644
--- a/packages/babel-plugin-transform-es2015-classes/test/fixtures/loose/method-return-type-annotation/expected.js
+++ b/packages/babel-plugin-transform-es2015-classes/test/fixtures/loose/method-return-type-annotation/expected.js
@@ -2,9 +2,11 @@
 var C = function () {
   function C() {}
 
-  C.prototype.m = function m(x: number): string {
+  var _proto = C.prototype;
+
+  _proto.m = function m(x: number): string {
     return 'a';
   };
 
   return C;
-}();
+}();
\ No newline at end of file
diff --git a/packages/babel-plugin-transform-es2015-classes/test/fixtures/loose/method-reuse-prototype/actual.js b/packages/babel-plugin-transform-es2015-classes/test/fixtures/loose/method-reuse-prototype/actual.js
new file mode 100644
index 0000000000000..1c08a36449802
--- /dev/null
+++ b/packages/babel-plugin-transform-es2015-classes/test/fixtures/loose/method-reuse-prototype/actual.js
@@ -0,0 +1,5 @@
+class Test {
+  a() {}
+  static b() {}
+  c() {}
+}
diff --git a/packages/babel-plugin-transform-es2015-classes/test/fixtures/loose/method-reuse-prototype/expected.js b/packages/babel-plugin-transform-es2015-classes/test/fixtures/loose/method-reuse-prototype/expected.js
new file mode 100644
index 0000000000000..859c173d159bb
--- /dev/null
+++ b/packages/babel-plugin-transform-es2015-classes/test/fixtures/loose/method-reuse-prototype/expected.js
@@ -0,0 +1,13 @@
+var Test = function () {
+  function Test() {}
+
+  var _proto = Test.prototype;
+
+  _proto.a = function a() {};
+
+  Test.b = function b() {};
+
+  _proto.c = function c() {};
+
+  return Test;
+}();
\ No newline at end of file
diff --git a/packages/babel-plugin-transform-es2015-classes/test/fixtures/regression/T6755/expected.js b/packages/babel-plugin-transform-es2015-classes/test/fixtures/regression/T6755/expected.js
index 74bafa673b0ab..0b335e4c1ae73 100644
--- a/packages/babel-plugin-transform-es2015-classes/test/fixtures/regression/T6755/expected.js
+++ b/packages/babel-plugin-transform-es2015-classes/test/fixtures/regression/T6755/expected.js
@@ -3,11 +3,13 @@
 var Example = function () {
   function Example() {}
 
-  Example.prototype.test1 = async function test1() {
+  var _proto = Example.prototype;
+
+  _proto.test1 = async function test1() {
     await Promise.resolve(2);
   };
 
-  Example.prototype.test2 = regeneratorRuntime.mark(function test2() {
+  _proto.test2 = regeneratorRuntime.mark(function test2() {
     return regeneratorRuntime.wrap(function test2$(_context) {
       while (1) {
         switch (_context.prev = _context.next) {
@@ -23,4 +25,4 @@ var Example = function () {
     }, test2, this);
   });
   return Example;
-}();
+}();
\ No newline at end of file
diff --git a/packages/babel-plugin-transform-flow-comments/test/fixtures/flow-comments/transformed-class-method-loose-return-type-annotation/expected.js b/packages/babel-plugin-transform-flow-comments/test/fixtures/flow-comments/transformed-class-method-loose-return-type-annotation/expected.js
index af26da01bc67c..0c3f51c0a95f1 100644
--- a/packages/babel-plugin-transform-flow-comments/test/fixtures/flow-comments/transformed-class-method-loose-return-type-annotation/expected.js
+++ b/packages/babel-plugin-transform-flow-comments/test/fixtures/flow-comments/transformed-class-method-loose-return-type-annotation/expected.js
@@ -4,7 +4,9 @@
 var C = function () {
   function C() {}
 
-  C.prototype.m = function m(x
+  var _proto = C.prototype;
+
+  _proto.m = function m(x
   /*: number*/
   )
   /*: string*/
@@ -13,4 +15,4 @@ var C = function () {
   };
 
   return C;
-}();
+}();
\ No newline at end of file
diff --git a/packages/babel-plugin-transform-flow-strip-types/test/fixtures/regression/transformed-class-method-loose-return-type-annotation/expected.js b/packages/babel-plugin-transform-flow-strip-types/test/fixtures/regression/transformed-class-method-loose-return-type-annotation/expected.js
index d3f42768b7218..abf414bec33d4 100644
--- a/packages/babel-plugin-transform-flow-strip-types/test/fixtures/regression/transformed-class-method-loose-return-type-annotation/expected.js
+++ b/packages/babel-plugin-transform-flow-strip-types/test/fixtures/regression/transformed-class-method-loose-return-type-annotation/expected.js
@@ -3,9 +3,11 @@
 var C = function () {
   function C() {}
 
-  C.prototype.m = function m(x) {
+  var _proto = C.prototype;
+
+  _proto.m = function m(x) {
     return 'a';
   };
 
   return C;
-}();
+}();
\ No newline at end of file