TileStache

A stylish alternative for caching your map tiles. TileStache is a Python-based server application that can serve up map tiles based on rendered geographic data. It’s an open source WMS server that is simple and suited to the needs of designers and cartographers.

tilestache.org

TileStache docs

sudo -u www-data tilestache-seed.py -c tilestache.cfg -l hybrid -b -50 3 53.5 8 -x 7 8 9 10

sudo -u www-data tilestache-seed.py -c tilestache.cfg -l hybrid -b -52.27 4.71 52.47 5.06 -x 11 12