diff --git a/compiler/noirc_evaluator/src/ssa/opt/simple_optimization.rs b/compiler/noirc_evaluator/src/ssa/opt/simple_optimization.rs
index e2c305f2db6..79136b6de8d 100644
--- a/compiler/noirc_evaluator/src/ssa/opt/simple_optimization.rs
+++ b/compiler/noirc_evaluator/src/ssa/opt/simple_optimization.rs
@@ -1,6 +1,6 @@
 //! Contains helper functions for performing SSA optimizations.
 
-use std::hash::BuildHasher;
+use std::{collections::HashSet, hash::BuildHasher};
 
 use iter_extended::vecmap;
 use noirc_errors::call_stack::CallStackId;
@@ -64,6 +64,7 @@ impl Function {
         F: FnMut(&mut SimpleOptimizationContext<'_, '_>) -> RtResult<()>,
     {
         let mut values_to_replace = ValueMapping::default();
+        let mut dirty_values = HashSet::<ValueId>::new();
         let one = self.dfg.make_constant(FieldElement::from(1_u128), NumericType::bool());
         let reverse_post_order = PostOrder::with_function(self).into_vec_reverse();
         for block_id in reverse_post_order {
@@ -91,6 +92,7 @@ impl Function {
                     insert_current_instruction_at_callback_end: true,
                     enable_side_effects,
                     orig_instruction_hash,
+                    dirty_values: &mut dirty_values,
                 };
                 f(&mut context)?;
 
@@ -117,6 +119,7 @@ pub(crate) struct SimpleOptimizationContext<'dfg, 'mapping> {
     values_to_replace: &'mapping mut ValueMapping,
     insert_current_instruction_at_callback_end: bool,
     orig_instruction_hash: u64,
+    dirty_values: &'mapping mut HashSet<ValueId>,
 }
 
 impl SimpleOptimizationContext<'_, '_> {
@@ -148,14 +151,17 @@ impl SimpleOptimizationContext<'_, '_> {
     /// If the instruction or its values has changed relative to their original content,
     /// we attempt to simplify the instruction before re-inserting it into the block.
     pub(crate) fn insert_current_instruction(&mut self) {
-        // If the instruction changed, then there is a chance that we can (or have to)
-        // simplify it before we insert it back into the block.
-        let simplify = self.has_instruction_changed();
+        // If the instruction changed, or if any of its values have changed, then there is a chance
+        // that we can (or have to) simplify it before we insert it back into the block.
+        let instruction_changed = self.has_instruction_changed();
+        let simplify = instruction_changed
+            || self.instruction().any_value(|value| self.dirty_values.contains(&value));
 
         if simplify {
             // Based on FunctionInserter::push_instruction_value.
             let instruction = self.instruction().clone();
             let results = self.dfg.instruction_results(self.instruction_id).to_vec();
+
             let ctrl_typevars = instruction
                 .requires_ctrl_typevars()
                 .then(|| vecmap(&results, |result| self.dfg.type_of_value(*result)));
@@ -169,6 +175,16 @@ impl SimpleOptimizationContext<'_, '_> {
             );
             assert_eq!(results.len(), new_results.len());
             for i in 0..results.len() {
+                if results[i] == new_results[i] && instruction_changed {
+                    // If the result didn't change, but the instruction itself did, we'd still like
+                    // to simplify instructions that depend on the unchanged result.
+                    // This for example can happen with a `v2 = make_array [v1]` that got turned
+                    // into `v2 = make_array [Field 0]`: `v2` didn't get a new result (it's not `v3`),
+                    // but an instruction that uses `v2` could get simplified now when it wasn't before
+                    // (an example is a call to `posiedon2_permutation(v2)`)
+                    self.dirty_values.insert(results[i]);
+                }
+
                 self.values_to_replace.insert(results[i], new_results[i]);
             }
         } else {
@@ -210,3 +226,54 @@ impl SimpleOptimizationContext<'_, '_> {
         self.dfg[self.instruction_id] = instruction;
     }
 }
+
+#[cfg(test)]
+mod tests {
+
+    #[test]
+    #[cfg(feature = "bn254")]
+    fn optimizes_instruction_dependent_on_changed_make_array() {
+        // Here `v2` will be optimized to Field 4, to `v3` will be an `make_array` with all
+        // constant values so `poseidon2_permutation` could be simplified to a constant array
+        // as well. However, that was not what was happening before it got fixed.
+        use crate::{assert_ssa_snapshot, ssa::ssa_gen::Ssa};
+        let src = "
+        acir(inline) predicate_pure fn main f0 {
+          b0(v0: u1):
+            enable_side_effects v0
+            v3 = make_array [Field 1, Field 3] : [Field; 2]
+            v5 = array_get v3, index u32 0 -> Field
+            v9 = make_array [v5, Field 10, Field 11, Field 12] : [Field; 4]
+            v11 = call poseidon2_permutation(v9) -> [Field; 4]
+            return v11
+        }
+        ";
+
+        // Replace the single array_get above with `Field 1`
+        let mut ssa = Ssa::from_str(src).unwrap();
+        let function = ssa.functions.get_mut(&ssa.main_id).unwrap();
+        function.simple_optimization(|context| {
+            use crate::ssa::ir::instruction::Instruction;
+            use crate::ssa::ir::types::NumericType;
+            use acvm::{AcirField, FieldElement};
+
+            if matches!(context.instruction(), Instruction::ArrayGet { .. }) {
+                let [result] = context.dfg.instruction_result(context.instruction_id);
+                let one = context.dfg.make_constant(FieldElement::one(), NumericType::NativeField);
+                context.replace_value(result, one);
+            }
+        });
+
+        assert_ssa_snapshot!(ssa, @r"
+        acir(inline) predicate_pure fn main f0 {
+          b0(v0: u1):
+            enable_side_effects v0
+            v3 = make_array [Field 1, Field 3] : [Field; 2]
+            v5 = array_get v3, index u32 0 -> Field
+            v9 = make_array [Field 1, Field 10, Field 11, Field 12] : [Field; 4]
+            v14 = make_array [Field 7240468757324361249024251542156303120112842951074264840229993254937937472979, Field 3930511960251438292111676743312909260363817810999911872670084465997185352894, Field -8290242092339083421336159442854929054877503377436860423462737517325762575981, Field -6733696266227305542524114733265413578952163219224437350266287764676147469720] : [Field; 4]
+            return v14
+        }
+        ");
+    }
+}