diff --git a/src/node_messaging.cc b/src/node_messaging.cc
index d3d2070d623c80..80c49c93c6bdaf 100644
--- a/src/node_messaging.cc
+++ b/src/node_messaging.cc
@@ -789,6 +789,13 @@ MaybeLocal<Value> MessagePort::ReceiveMessage(Local<Context> context,
 
 void MessagePort::OnMessage(MessageProcessingMode mode) {
   Debug(this, "Running MessagePort::OnMessage()");
+  // Maybe the async handle was triggered empty or more than needed.
+  // The data_ could be freed or, the handle has been/is being closed.
+  // A possible case for this, is transfer the MessagePort to another
+  // context, it will call the constructor and trigger the async handle empty.
+  // Because all data was sent from the preivous context.
+  if (IsDetached()) return;
+
   HandleScope handle_scope(env()->isolate());
   Local<Context> context =
       object(env()->isolate())->GetCreationContext().ToLocalChecked();
diff --git a/test/parallel/test-worker-workerdata-messageport.js b/test/parallel/test-worker-workerdata-messageport.js
index 18f05731e8f635..0df48465a071b1 100644
--- a/test/parallel/test-worker-workerdata-messageport.js
+++ b/test/parallel/test-worker-workerdata-messageport.js
@@ -1,11 +1,11 @@
 'use strict';
 
 require('../common');
-const assert = require('assert');
+const assert = require('node:assert');
 
 const {
   Worker, MessageChannel
-} = require('worker_threads');
+} = require('node:worker_threads');
 
 const channel = new MessageChannel();
 const workerData = { mesage: channel.port1 };
@@ -59,3 +59,29 @@ const meowScript = () => 'meow';
              'listed in transferList'
   });
 }
+
+{
+  // Should not crash when MessagePort is transferred to another context.
+  // https://github.com/nodejs/node/issues/49075
+  const channel = new MessageChannel();
+  new Worker(`
+    const { runInContext, createContext } = require('node:vm')
+    const { workerData } = require('worker_threads');
+    const context = createContext(Object.create(null));
+    context.messagePort = workerData.messagePort;
+    runInContext(
+      \`messagePort.postMessage("Meow")\`,
+      context,
+      { displayErrors: true }
+    );
+    `, {
+    eval: true,
+    workerData: { messagePort: channel.port2 },
+    transferList: [channel.port2]
+  });
+  channel.port1.on(
+    'message',
+    (message) =>
+      assert.strictEqual(message, 'Meow')
+  );
+}