diff --git a/CHANGELOG.md b/CHANGELOG.md
index e5abdb7d..59992a29 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -6,6 +6,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 ## v4.1.0dev
 
 - Update nextflow_schema.json
+- Fix simpleaf protocol name for 10xv4 ([#452](https://github.com/nf-core/scrnaseq/pull/452))
 
 ## v4.0.0 - 2025-03-10
 
diff --git a/assets/protocols.json b/assets/protocols.json
index 34979228..ddfd41bf 100644
--- a/assets/protocols.json
+++ b/assets/protocols.json
@@ -13,7 +13,7 @@
             "whitelist": "assets/whitelist/10x_V3_barcode_whitelist.txt.gz"
         },
         "10XV4": {
-            "protocol": "10xv4",
+            "protocol": "10xv4-3p",
             "whitelist": "assets/whitelist/10x_V4_barcode_whitelist.txt.gz"
         },
         "dropseq": {