diff --git a/.github/actions/setup-python-matrix/action.yml b/.github/actions/setup-python-matrix/action.yml
index a2dc77e60..299dd2e7b 100644
--- a/.github/actions/setup-python-matrix/action.yml
+++ b/.github/actions/setup-python-matrix/action.yml
@@ -47,4 +47,4 @@ runs:
       shell: bash
       run: |
         python3.10 -m pip install -U pip
-        python3.10 -m pip install -U wheel setuptools 'tox<4' 'virtualenv<20.22.0'
+        python3.10 -m pip install -U wheel setuptools tox 'virtualenv<20.22.0'
diff --git a/tox.ini b/tox.ini
index 2477f959c..147851088 100644
--- a/tox.ini
+++ b/tox.ini
@@ -408,10 +408,10 @@ commands =
     libcurl: pip install --ignore-installed --config-settings="--build-option=--with-openssl" pycurl
     coverage run -m pytest -v
 
+allowlist_externals={toxinidir}/.github/scripts/*
+
 install_command=
-    # Older pip versions that support python 2 have issues with using the cache directory and cause crashes on GitHub Actions
-    {py27,pypy}: {toxinidir}/.github/scripts/retry.sh 3 pip install --no-cache-dir {opts} {packages}
-    !{py27,pypy}: {toxinidir}/.github/scripts/retry.sh 3 pip install {opts} {packages}
+    {toxinidir}/.github/scripts/retry.sh 3 pip install {opts} {packages}
 
 extras =
     agent_streaming: infinite-tracing