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Tables and Acknowledgements paper.md
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@@ -45,9 +45,7 @@ NEAT can integrate seamlessly with existing bioinformatics workflows, providing
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# Tables
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## Algorithmic Improvements and Methodological Changes
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### Table 1. Enhancements in Algorithmic Performance
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### Table 1. Algorithmic Improvements and Methodological Changes
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| # | Feature Name | Prior Implementation (v2.0) | Updated Implementation (v4.X) |
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|---|-------------|------------------------------|--------------------------------|
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## Performance Enhancements and User-Centric Modifications
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### Table 2. Performance and User Experience Improvements
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### Table 2. Improvements in User Experience
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| # | Feature Name | Prior Implementation (v2.0) | Updated Implementation (v4.X) |
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|---|-------------|------------------------------|--------------------------------|
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| 1 | **Automated Testing** | No formal testing framework | Implemented continuous integration with GitHub-based automated tests |
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|---|-------------|------------------------------|--------------------------------|
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| 2 | **Refactored Unit Testing** | Monolithic, unstructured codebase | Rewritten with testable, discrete functions |
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| 2 | **Configuration Files** | Required explicit command-line flags | Introduced structured configuration files |
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|---|-------------|------------------------------|--------------------------------|
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| 3 | **Friendly Installation** | Not installable as a package | Fully modular and pip-installable via Poetry |
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|---|-------------|------------------------------|--------------------------------|
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| 4 | **Configuration Files** | Required explicit command-line flags | Introduced structured configuration files |
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| 4 | **Refactored Unit Testing** | Not originally present | Rewritten with testable, discrete functions |
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**1** was implemented to address the lack of a formal testing structure. The new continuous integration (CI) pipeline detects bugs early, streamlining development and enhancing error detection (e.g., handling of BED files and other inputs). **2** improved debugging and maintenance by transitioning from a monolithic structure to a modular approach with testable, discrete functions, enhancing code integrity and collaboration. **3** was introduced to address the previous lack of package installation support, making NEAT 4.X modular and pip-installable via Poetry, which enhances portability and development ease. Lastly, **4** improved usability, debugging, and reproducibility by replacing cumbersome command-line flags with structured configuration files.
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**1** was implemented to address the lack of a formal testing structure. The new continuous integration (CI) pipeline detects bugs early, streamlining development and enhancing error detection (e.g., handling of BED files and other inputs). **2** improved usability, debugging, and reproducibility by replacing cumbersome command-line flags with structured configuration files. **3** was introduced to address the previous lack of package installation support, making NEAT 4.X modular and pip-installable via Poetry, which enhances portability and development ease. Lastly, **4** improved debugging and maintenance by transitioning from a monolithic structure to a modular approach with testable, discrete functions, enhancing code integrity and collaboration.
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# Acknowledgements
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We thank the original creators of NEAT. We also thank Raghid, Yash, Varenya, and Karen.
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We thank the original creators of NEAT: Zachary D. Stephens, Matthew E. Hudson, Liudmila S. Mainzer, Morgan Taschuk, Matthew R. Weber, and Ravishankar K. Iyer.
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We also thank Raghid Alhamzy, Yash Wasnik, Varenya Jain, and Karen H. Xiong.
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# References
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1. Stephens ZD, Hudson ME, Mainzer LS, Taschuk M, Weber MR, Iyer RK. Simulating Next-Generation Sequencing Datasets from Empirical Mutation and Sequencing Models. PLOS ONE. 2016;11(11). doi:10.1371/journal.pone.0167047

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