diff --git a/server/jetstream_cluster_1_test.go b/server/jetstream_cluster_1_test.go
index e480db7080c..8b2e54cb168 100644
--- a/server/jetstream_cluster_1_test.go
+++ b/server/jetstream_cluster_1_test.go
@@ -10447,6 +10447,122 @@ func TestJetStreamClusterJszRaftLeaderReporting(t *testing.T) {
 	}
 }
 
+func TestJetStreamClusterNoInterestDesyncOnConsumerCreate(t *testing.T) {
+	c := createJetStreamClusterExplicit(t, "R3S", 3)
+	defer c.shutdown()
+
+	nc, js := jsClientConnect(t, c.randomServer())
+	defer nc.Close()
+
+	_, err := js.AddStream(&nats.StreamConfig{
+		Name:      "TEST",
+		Subjects:  []string{"foo"},
+		Replicas:  3,
+		Retention: nats.InterestPolicy,
+	})
+	require_NoError(t, err)
+
+	// Pick a random server that will not know about the new consumer being created.
+	// If servers determine "no interest" individually, these servers will desync.
+	rs := c.randomNonLeader()
+	sjs := rs.getJetStream()
+	meta := sjs.getMetaGroup()
+	require_NoError(t, meta.PauseApply())
+
+	sub, err := js.PullSubscribe(_EMPTY_, "DURABLE", nats.BindStream("TEST"))
+	require_NoError(t, err)
+	defer sub.Drain()
+
+	checkConsumersAssigned := func(expected int) {
+		t.Helper()
+		checkFor(t, 2*time.Second, 200*time.Millisecond, func() error {
+			var count int
+			for _, s := range c.servers {
+				_, _, jsa := s.globalAccount().getJetStreamFromAccount()
+				if jsa.consumerAssigned("TEST", "DURABLE") {
+					count++
+				}
+			}
+			if count != expected {
+				return fmt.Errorf("expected %d, got %d", expected, count)
+			}
+			return nil
+		})
+	}
+	// Confirm only two servers know about the consumer.
+	checkConsumersAssigned(2)
+	c.waitOnConsumerLeader(globalAccountName, "TEST", "DURABLE")
+
+	// Publish a single message. All servers will receive this, but only two will store it.
+	_, err = js.Publish("foo", nil)
+	require_NoError(t, err)
+	checkLastSeq := func(lseq uint64) {
+		t.Helper()
+		checkFor(t, 2*time.Second, 200*time.Millisecond, func() error {
+			for _, s := range c.servers {
+				mset, err := s.globalAccount().lookupStream("TEST")
+				if err != nil {
+					return err
+				}
+				if seq := mset.lastSeq(); seq != lseq {
+					return fmt.Errorf("expected %d, got %d", lseq, seq)
+				}
+			}
+			return nil
+		})
+	}
+	checkLastSeq(1)
+
+	// Resume the meta layer such that the consumer gets created on the remaining server.
+	meta.ResumeApply()
+	checkConsumersAssigned(3)
+
+	// All servers will now store another published message.
+	_, err = js.Publish("foo", nil)
+	require_NoError(t, err)
+	checkLastSeq(2)
+
+	// Make sure the consumer leader is on the same server that didn't store the first message.
+	cl := c.consumerLeader(globalAccountName, "TEST", "DURABLE")
+	if cl != rs {
+		mset, err := cl.globalAccount().lookupStream("TEST")
+		require_NoError(t, err)
+		o := mset.lookupConsumer("DURABLE")
+		require_NotNil(t, o)
+		n := o.raftNode()
+		require_NoError(t, n.StepDown(rs.NodeName()))
+		c.waitOnConsumerLeader(globalAccountName, "TEST", "DURABLE")
+		cl = c.consumerLeader(globalAccountName, "TEST", "DURABLE")
+		require_Equal(t, cl, rs)
+	}
+
+	// Since the consumer leader is the same as the server that didn't store the first message,
+	// it can only receive and ack the second message.
+	msgs, err := sub.Fetch(1, nats.MaxWait(time.Second))
+	require_NoError(t, err)
+	require_Len(t, len(msgs), 1)
+	metadata, err := msgs[0].Metadata()
+	require_NoError(t, err)
+	require_Equal(t, metadata.Sequence.Stream, 2)
+	require_Equal(t, metadata.NumPending, 0)
+	require_NoError(t, msgs[0].AckSync())
+
+	checkFor(t, 2*time.Second, 200*time.Millisecond, func() error {
+		// The servers will eventually be synced up again, but this relies on the interest state being checked.
+		for _, s := range c.servers {
+			if s == rs {
+				continue
+			}
+			mset, err := s.globalAccount().lookupStream("TEST")
+			if err != nil {
+				return err
+			}
+			mset.checkInterestState()
+		}
+		return checkState(t, c, globalAccountName, "TEST")
+	})
+}
+
 //
 // DO NOT ADD NEW TESTS IN THIS FILE (unless to balance test times)
 // Add at the end of jetstream_cluster_<n>_test.go, with <n> being the highest value.
diff --git a/server/stream.go b/server/stream.go
index bbc9834593f..5c72329d065 100644
--- a/server/stream.go
+++ b/server/stream.go
@@ -7607,7 +7607,19 @@ func (mset *stream) ackMsg(o *consumer, seq uint64) bool {
 	// Only propose message deletion to the stream if we're consumer leader, otherwise all followers would also propose.
 	// We must be the consumer leader, since we know for sure we've stored the message and don't register as pre-ack.
 	if o != nil && !o.IsLeader() {
+		// Currently, interest-based streams can race on "no interest" because consumer creates/updates go over
+		// the meta layer and published messages go over the stream layer. Some servers could then either store
+		// or not store some initial set of messages that gained new interest. To get the stream back in sync,
+		// we allow moving the first sequence up.
+		// TODO(mvv): later on only the stream leader should determine "no interest"
+		interestRaiseFirst := mset.cfg.Retention == InterestPolicy && seq == state.FirstSeq
 		mset.mu.Unlock()
+		if interestRaiseFirst {
+			if _, err := store.RemoveMsg(seq); err == ErrStoreEOF {
+				// This should not happen, but being pedantic.
+				mset.registerPreAckLock(o, seq)
+			}
+		}
 		// Must still mark as removal if follower. If we become leader later, we must be able to retry the proposal.
 		return true
 	}