diff --git a/.github/workflows/windows_qnn_x64.yml b/.github/workflows/windows_qnn_x64.yml
index 7b4c5663de96c..b27243c1cfde1 100644
--- a/.github/workflows/windows_qnn_x64.yml
+++ b/.github/workflows/windows_qnn_x64.yml
@@ -51,14 +51,14 @@ jobs:
       - name: Download QNN SDK
         working-directory: ${{ runner.temp }}
         run: |
-          azcopy.exe cp --recursive https://lotusscus.blob.core.windows.net/models/qnnsdk/qnn-v2.39.0.250926 .
+          azcopy.exe cp --recursive https://lotusscus.blob.core.windows.net/models/qnnsdk/qnn-v2.41.0.251128 .
           dir
         shell: pwsh
 
       - name: Set QNN_SDK_ROOT environment variable
         shell: pwsh
         run: |
-          $qnn_sdk_path = Join-Path $env:RUNNER_TEMP "qnn-v2.39.0.250926"
+          $qnn_sdk_path = Join-Path $env:RUNNER_TEMP "qnn-v2.41.0.251128"
           echo "QNN_SDK_ROOT=$qnn_sdk_path" | Out-File -FilePath $env:GITHUB_ENV -Encoding utf8 -Append
           echo "QNN SDK Root: $qnn_sdk_path"
           dir $qnn_sdk_path
diff --git a/tools/ci_build/github/azure-pipelines/android-arm64-v8a-QNN-crosscompile-ci-pipeline.yml b/tools/ci_build/github/azure-pipelines/android-arm64-v8a-QNN-crosscompile-ci-pipeline.yml
index de7beb7c5c092..56dcf9f022df4 100644
--- a/tools/ci_build/github/azure-pipelines/android-arm64-v8a-QNN-crosscompile-ci-pipeline.yml
+++ b/tools/ci_build/github/azure-pipelines/android-arm64-v8a-QNN-crosscompile-ci-pipeline.yml
@@ -32,7 +32,7 @@ parameters:
 - name: QnnSdk
   displayName: QNN SDK version
   type: string
-  default: 2.39.0.250926
+  default: 2.41.0.251128
 
 jobs:
 - job: Build_QNN_EP
diff --git a/tools/ci_build/github/azure-pipelines/c-api-noopenmp-packaging-pipelines.yml b/tools/ci_build/github/azure-pipelines/c-api-noopenmp-packaging-pipelines.yml
index 9b7a5953aaeab..d25769e324416 100644
--- a/tools/ci_build/github/azure-pipelines/c-api-noopenmp-packaging-pipelines.yml
+++ b/tools/ci_build/github/azure-pipelines/c-api-noopenmp-packaging-pipelines.yml
@@ -55,7 +55,7 @@ parameters:
 - name: QnnSdk
   displayName: QNN SDK Version
   type: string
-  default: 2.39.0.250926
+  default: 2.41.0.251128
 
 - name: CudaVersion
   displayName: CUDA version
diff --git a/tools/ci_build/github/azure-pipelines/c-api-noopenmp-test-pipelines.yml b/tools/ci_build/github/azure-pipelines/c-api-noopenmp-test-pipelines.yml
index 1a3959aecae65..1366112b9df3c 100644
--- a/tools/ci_build/github/azure-pipelines/c-api-noopenmp-test-pipelines.yml
+++ b/tools/ci_build/github/azure-pipelines/c-api-noopenmp-test-pipelines.yml
@@ -83,7 +83,7 @@ stages:
       artifactName: 'onnxruntime-android-qnn-aar'
       packageName: 'onnxruntime-android-qnn'
       #TODO: get this information from the setup stage
-      QnnSDKVersion: '2.39.0.250926'
+      QnnSDKVersion: '2.41.0.251128'
 
 - template: nuget/templates/test_win.yml
   parameters:
diff --git a/tools/ci_build/github/azure-pipelines/custom-nuget-packaging-pipeline.yml b/tools/ci_build/github/azure-pipelines/custom-nuget-packaging-pipeline.yml
index 8d02b39bc043d..6ae40fcf402f4 100644
--- a/tools/ci_build/github/azure-pipelines/custom-nuget-packaging-pipeline.yml
+++ b/tools/ci_build/github/azure-pipelines/custom-nuget-packaging-pipeline.yml
@@ -6,7 +6,7 @@ parameters:
 - name: QnnSdk
   displayName: QNN SDK Version
   type: string
-  default: 2.39.0.250926
+  default: 2.41.0.251128
 
 - name: IsReleaseBuild
   displayName: Is a release build? Set it to true if you are doing an Onnx Runtime release.
diff --git a/tools/ci_build/github/azure-pipelines/linux-qnn-ci-pipeline.yml b/tools/ci_build/github/azure-pipelines/linux-qnn-ci-pipeline.yml
index 6e6977bb76f12..b5866cfe1b0cf 100644
--- a/tools/ci_build/github/azure-pipelines/linux-qnn-ci-pipeline.yml
+++ b/tools/ci_build/github/azure-pipelines/linux-qnn-ci-pipeline.yml
@@ -33,7 +33,7 @@ parameters:
 - name: QnnSdk
   displayName: QNN SDK version
   type: string
-  default: 2.39.0.250926
+  default: 2.41.0.251128
 
 jobs:
   - job: Build_QNN_EP
diff --git a/tools/ci_build/github/azure-pipelines/py-packaging-pipeline.yml b/tools/ci_build/github/azure-pipelines/py-packaging-pipeline.yml
index 12dbda7503973..a98fdddb39bda 100644
--- a/tools/ci_build/github/azure-pipelines/py-packaging-pipeline.yml
+++ b/tools/ci_build/github/azure-pipelines/py-packaging-pipeline.yml
@@ -59,7 +59,7 @@ parameters:
 - name: qnn_sdk_version
   type: string
   displayName: 'QNN SDK version. Only for QNN packages.'
-  default: 2.39.0.250926
+  default: 2.41.0.251128
 
 trigger: none
 
diff --git a/tools/ci_build/github/azure-pipelines/qnn-ep-nuget-packaging-pipeline.yml b/tools/ci_build/github/azure-pipelines/qnn-ep-nuget-packaging-pipeline.yml
index 53a803f957420..b170c53d8c18e 100644
--- a/tools/ci_build/github/azure-pipelines/qnn-ep-nuget-packaging-pipeline.yml
+++ b/tools/ci_build/github/azure-pipelines/qnn-ep-nuget-packaging-pipeline.yml
@@ -2,7 +2,7 @@ parameters:
 - name: QnnSdk
   displayName: QNN SDK Version
   type: string
-  default: 2.39.0.250926
+  default: 2.41.0.251128
 
 - name: build_config
   displayName: Build Configuration
diff --git a/tools/ci_build/github/azure-pipelines/stages/py-cpu-packaging-stage.yml b/tools/ci_build/github/azure-pipelines/stages/py-cpu-packaging-stage.yml
index 9404451d3a609..1d4c9b7041a70 100644
--- a/tools/ci_build/github/azure-pipelines/stages/py-cpu-packaging-stage.yml
+++ b/tools/ci_build/github/azure-pipelines/stages/py-cpu-packaging-stage.yml
@@ -59,7 +59,7 @@ parameters:
 - name: qnn_sdk_version
   type: string
   displayName: 'QNN SDK version. Only for QNN packages.'
-  default: 2.39.0.250926
+  default: 2.41.0.251128
 
 stages:
 - ${{ if eq(parameters.enable_windows_cpu, true) }}:
diff --git a/tools/ci_build/github/azure-pipelines/templates/android-java-api-aar-test.yml b/tools/ci_build/github/azure-pipelines/templates/android-java-api-aar-test.yml
index 42b607eabcc40..0c4d72e623099 100644
--- a/tools/ci_build/github/azure-pipelines/templates/android-java-api-aar-test.yml
+++ b/tools/ci_build/github/azure-pipelines/templates/android-java-api-aar-test.yml
@@ -19,7 +19,7 @@ parameters:
 - name: QnnSDKVersion
   displayName: QNN SDK Version
   type: string
-  default: '2.39.0.250926'
+  default: '2.41.0.251128'
 
 - name: enableWebGpu
   displayName: Enable WebGPU test
diff --git a/tools/ci_build/github/azure-pipelines/templates/android-java-api-aar.yml b/tools/ci_build/github/azure-pipelines/templates/android-java-api-aar.yml
index 38de9e1ad8fbc..601c6bf29c55a 100644
--- a/tools/ci_build/github/azure-pipelines/templates/android-java-api-aar.yml
+++ b/tools/ci_build/github/azure-pipelines/templates/android-java-api-aar.yml
@@ -53,7 +53,7 @@ parameters:
 - name: QnnSDKVersion
   displayName: QNN SDK Version
   type: string
-  default: '2.39.0.250926'
+  default: '2.41.0.251128'
 
 - name: is1ES
   displayName: Is 1ES pipeline
diff --git a/tools/ci_build/github/azure-pipelines/templates/c-api-cpu.yml b/tools/ci_build/github/azure-pipelines/templates/c-api-cpu.yml
index 7af23519caafb..a642472941033 100644
--- a/tools/ci_build/github/azure-pipelines/templates/c-api-cpu.yml
+++ b/tools/ci_build/github/azure-pipelines/templates/c-api-cpu.yml
@@ -46,7 +46,7 @@ parameters:
 - name: QnnSDKVersion
   displayName: QNN SDK Version
   type: string
-  default: 2.39.0.250926
+  default: 2.41.0.251128
 
 - name: is1ES
   displayName: Is 1ES pipeline
diff --git a/tools/ci_build/github/azure-pipelines/templates/jobs/download_linux_qnn_sdk.yml b/tools/ci_build/github/azure-pipelines/templates/jobs/download_linux_qnn_sdk.yml
index 8442d6db4feb4..929edf19806ed 100644
--- a/tools/ci_build/github/azure-pipelines/templates/jobs/download_linux_qnn_sdk.yml
+++ b/tools/ci_build/github/azure-pipelines/templates/jobs/download_linux_qnn_sdk.yml
@@ -1,7 +1,7 @@
 parameters:
   - name: QnnSDKVersion
     type: string
-    default: '2.39.0.250926'
+    default: '2.41.0.251128'
 
 steps:
   - script: |
diff --git a/tools/ci_build/github/azure-pipelines/templates/jobs/download_win_qnn_sdk.yml b/tools/ci_build/github/azure-pipelines/templates/jobs/download_win_qnn_sdk.yml
index 61e67910f5c9c..19d2ca6cf4721 100644
--- a/tools/ci_build/github/azure-pipelines/templates/jobs/download_win_qnn_sdk.yml
+++ b/tools/ci_build/github/azure-pipelines/templates/jobs/download_win_qnn_sdk.yml
@@ -1,7 +1,7 @@
 parameters:
   - name: QnnSDKVersion
     type: string
-    default: '2.39.0.250926'
+    default: '2.41.0.251128'
 
 steps:
   - powershell: |
diff --git a/tools/ci_build/github/azure-pipelines/templates/jobs/init_linux_qnn_sdk_x64.yml b/tools/ci_build/github/azure-pipelines/templates/jobs/init_linux_qnn_sdk_x64.yml
index b1dd26ff8da93..2ce36be71d5a3 100644
--- a/tools/ci_build/github/azure-pipelines/templates/jobs/init_linux_qnn_sdk_x64.yml
+++ b/tools/ci_build/github/azure-pipelines/templates/jobs/init_linux_qnn_sdk_x64.yml
@@ -1,7 +1,7 @@
 parameters:
   - name: QnnSDKVersion
     type: string
-    default: '2.39.0.250926'
+    default: '2.41.0.251128'
 
 steps:
   - bash: |
diff --git a/tools/ci_build/github/azure-pipelines/templates/py-linux-qnn.yml b/tools/ci_build/github/azure-pipelines/templates/py-linux-qnn.yml
index 953ffe7e2e23c..c987de3ef9abb 100644
--- a/tools/ci_build/github/azure-pipelines/templates/py-linux-qnn.yml
+++ b/tools/ci_build/github/azure-pipelines/templates/py-linux-qnn.yml
@@ -26,7 +26,7 @@ parameters:
 - name: QnnSdk
   displayName: QNN SDK version
   type: string
-  default: 2.39.0.250926
+  default: 2.41.0.251128
 
 - name: is1ES
   displayName: 'Whether the pipeline is running in 1ES'
diff --git a/tools/ci_build/github/azure-pipelines/templates/py-win-arm64-qnn.yml b/tools/ci_build/github/azure-pipelines/templates/py-win-arm64-qnn.yml
index 2ee7ebc9560ac..baac9af8f979a 100644
--- a/tools/ci_build/github/azure-pipelines/templates/py-win-arm64-qnn.yml
+++ b/tools/ci_build/github/azure-pipelines/templates/py-win-arm64-qnn.yml
@@ -11,7 +11,7 @@ parameters:
 - name: QNN_SDK
   displayName: QNN SDK Version
   type: string
-  default: 2.39.0.250926
+  default: 2.41.0.251128
 
 - name: ENV_SETUP_SCRIPT
   type: string
diff --git a/tools/ci_build/github/azure-pipelines/templates/py-win-arm64ec-qnn.yml b/tools/ci_build/github/azure-pipelines/templates/py-win-arm64ec-qnn.yml
index f80c06aba829d..661179b027eb9 100644
--- a/tools/ci_build/github/azure-pipelines/templates/py-win-arm64ec-qnn.yml
+++ b/tools/ci_build/github/azure-pipelines/templates/py-win-arm64ec-qnn.yml
@@ -7,7 +7,7 @@ parameters:
 - name: QNN_SDK
   displayName: QNN SDK Version
   type: string
-  default: 2.39.0.250926
+  default: 2.41.0.251128
 
 - name: ENV_SETUP_SCRIPT
   type: string
diff --git a/tools/ci_build/github/azure-pipelines/templates/py-win-x64-qnn.yml b/tools/ci_build/github/azure-pipelines/templates/py-win-x64-qnn.yml
index f8412f514c9ac..56a0d702875cf 100644
--- a/tools/ci_build/github/azure-pipelines/templates/py-win-x64-qnn.yml
+++ b/tools/ci_build/github/azure-pipelines/templates/py-win-x64-qnn.yml
@@ -7,7 +7,7 @@ parameters:
 - name: QNN_SDK
   displayName: QNN SDK Version
   type: string
-  default: 2.39.0.250926
+  default: 2.41.0.251128
 
 - name: ENV_SETUP_SCRIPT
   type: string
diff --git a/tools/ci_build/github/azure-pipelines/templates/qnn-ep-win.yml b/tools/ci_build/github/azure-pipelines/templates/qnn-ep-win.yml
index 90cd6ccf6d110..856d48f535470 100644
--- a/tools/ci_build/github/azure-pipelines/templates/qnn-ep-win.yml
+++ b/tools/ci_build/github/azure-pipelines/templates/qnn-ep-win.yml
@@ -1,5 +1,5 @@
 parameters:
-  QnnSdk: '2.39.0.250926'
+  QnnSdk: '2.41.0.251128'
   build_config: 'RelWithDebInfo'
   IsReleaseBuild: false
   DoEsrp: false
diff --git a/tools/ci_build/github/azure-pipelines/win-qnn-arm64-ci-pipeline.yml b/tools/ci_build/github/azure-pipelines/win-qnn-arm64-ci-pipeline.yml
index c0a9c235fd542..bff3b4e3c3362 100644
--- a/tools/ci_build/github/azure-pipelines/win-qnn-arm64-ci-pipeline.yml
+++ b/tools/ci_build/github/azure-pipelines/win-qnn-arm64-ci-pipeline.yml
@@ -33,7 +33,7 @@ parameters:
 - name: QnnSdk
   displayName: QNN SDK version
   type: string
-  default: 2.39.0.250926
+  default: 2.41.0.251128
 
 jobs:
 - job: 'BUILD_QNN_EP'