diff --git a/cmake/CMakeLists.txt b/cmake/CMakeLists.txt
index 2714e6f59dbac..0b32d51884c05 100644
--- a/cmake/CMakeLists.txt
+++ b/cmake/CMakeLists.txt
@@ -1512,6 +1512,11 @@ if (onnxruntime_USE_OPENVINO)
 
 endif()
 
+if (onnxruntime_USE_OPENVINO_INTERFACE AND (NOT onnxruntime_USE_OPENVINO))
+    add_definitions(-DUSE_OPENVINO=1)
+    add_definitions(-DOPENVINO_CONFIG_NPU=1)
+endif()
+
 if (onnxruntime_USE_VITISAI)
     set(CMAKE_MODULE_PATH "${CMAKE_MODULE_PATH};${CMAKE_CURRENT_LIST_DIR}")
 endif()
diff --git a/tools/ci_build/build.py b/tools/ci_build/build.py
index ecdffbe5fd6a0..c1c0aa77ca9c1 100644
--- a/tools/ci_build/build.py
+++ b/tools/ci_build/build.py
@@ -1502,7 +1502,7 @@ def generate_build_tree(
         ]
 
     # VitisAI and OpenVINO providers currently only support full_protobuf option.
-    if args.use_full_protobuf or args.use_openvino or args.use_vitisai or args.gen_doc:
+    if args.use_full_protobuf or args.use_openvino or args.use_vitisai or args.gen_doc or args.enable_generic_interface:
         cmake_args += ["-Donnxruntime_USE_FULL_PROTOBUF=ON", "-DProtobuf_USE_STATIC_LIBS=ON"]
 
     if args.use_cuda and not is_windows():
diff --git a/tools/ci_build/github/azure-pipelines/linux-openvino-ci-pipeline.yml b/tools/ci_build/github/azure-pipelines/linux-openvino-ci-pipeline.yml
index c7b814f3dd52c..e89fa0ece2c76 100644
--- a/tools/ci_build/github/azure-pipelines/linux-openvino-ci-pipeline.yml
+++ b/tools/ci_build/github/azure-pipelines/linux-openvino-ci-pipeline.yml
@@ -33,5 +33,5 @@ jobs:
   parameters:
     AgentPool : 'Linux-CPU-2019'
     JobName: 'Linux_CI_Dev'
-    RunDockerBuildArgs: '-o ubuntu22.04 -p 3.10 -d openvino -v 2024.5.0 -x "--use_openvino CPU --build_wheel"'
+    RunDockerBuildArgs: '-o ubuntu22.04 -p 3.10 -d openvino -v 2024.5.0 -x "--enable_generic_interface --use_openvino CPU --build_wheel"'
     TimeoutInMinutes: 120
diff --git a/tools/ci_build/github/azure-pipelines/win-gpu-tensorrt-ci-pipeline.yml b/tools/ci_build/github/azure-pipelines/win-gpu-tensorrt-ci-pipeline.yml
index 3d3e53b680d45..5c6d9dd6ed955 100644
--- a/tools/ci_build/github/azure-pipelines/win-gpu-tensorrt-ci-pipeline.yml
+++ b/tools/ci_build/github/azure-pipelines/win-gpu-tensorrt-ci-pipeline.yml
@@ -92,7 +92,7 @@ jobs:
      del wheel_filename_file
      python.exe -m pip install -q --upgrade %WHEEL_FILENAME%
      set PATH=$(Build.BinariesDirectory)\RelWithDebInfo\RelWithDebInfo;%PATH%
-     python $(Build.SourcesDirectory)\tools\ci_build\build.py --config RelWithDebInfo --use_binskim_compliant_compile_flags --build_dir $(Build.BinariesDirectory) --skip_submodule_sync --build_shared_lib --test --cmake_generator "Visual Studio 17 2022" --build_wheel --enable_onnx_tests --use_tensorrt --tensorrt_home="$(Agent.TempDirectory)\${{ variables.win_trt_folder }}"  --cuda_home="$(Agent.TempDirectory)\v${{ parameters.CudaVersion }}" --use_vcpkg --use_vcpkg_ms_internal_asset_cache --cmake_extra_defines CMAKE_CUDA_ARCHITECTURES=86
+     python $(Build.SourcesDirectory)\tools\ci_build\build.py --config RelWithDebInfo --use_binskim_compliant_compile_flags --build_dir $(Build.BinariesDirectory) --skip_submodule_sync --enable_generic_interface --build_shared_lib --test --cmake_generator "Visual Studio 17 2022" --build_wheel --enable_onnx_tests --use_tensorrt --tensorrt_home="$(Agent.TempDirectory)\${{ variables.win_trt_folder }}"  --cuda_home="$(Agent.TempDirectory)\v${{ parameters.CudaVersion }}" --use_vcpkg --use_vcpkg_ms_internal_asset_cache --cmake_extra_defines CMAKE_CUDA_ARCHITECTURES=86
 
     workingDirectory: '$(Build.BinariesDirectory)\RelWithDebInfo\RelWithDebInfo'
     displayName: 'Run tests'