diff --git a/common/changes/office-ui-fabric-react/chiechan-allowFocusToReturnInPopup_2018-05-07-22-58.json b/common/changes/office-ui-fabric-react/chiechan-allowFocusToReturnInPopup_2018-05-07-22-58.json
new file mode 100644
index 00000000000000..5396b467e38a9e
--- /dev/null
+++ b/common/changes/office-ui-fabric-react/chiechan-allowFocusToReturnInPopup_2018-05-07-22-58.json
@@ -0,0 +1,11 @@
+{
+  "changes": [
+    {
+      "packageName": "office-ui-fabric-react",
+      "comment": "Popup: Added check for onBlur to prevent focus setting focus to be disabled in chrome",
+      "type": "patch"
+    }
+  ],
+  "packageName": "office-ui-fabric-react",
+  "email": "chiechan@microsoft.com"
+}
\ No newline at end of file
diff --git a/packages/office-ui-fabric-react/src/components/Popup/Popup.tsx b/packages/office-ui-fabric-react/src/components/Popup/Popup.tsx
index 5c265313fb493a..2d4d3367697b47 100644
--- a/packages/office-ui-fabric-react/src/components/Popup/Popup.tsx
+++ b/packages/office-ui-fabric-react/src/components/Popup/Popup.tsx
@@ -141,7 +141,9 @@ export class Popup extends BaseComponent<IPopupProps, IPopupState> {
     this._containsFocus = true;
   }
 
-  private _onBlur(): void {
-    this._containsFocus = false;
+  private _onBlur(ev: React.FocusEvent<HTMLElement>): void {
+    if (this._root.value && this._root.value.contains(ev.relatedTarget as HTMLElement)) {
+      this._containsFocus = false;
+    }
   }
 }