diff --git a/common/changes/office-ui-fabric-react/redo-focuszone-change_2018-04-15-19-20.json b/common/changes/office-ui-fabric-react/redo-focuszone-change_2018-04-15-19-20.json
new file mode 100644
index 00000000000000..cf6dfeb297c7d0
--- /dev/null
+++ b/common/changes/office-ui-fabric-react/redo-focuszone-change_2018-04-15-19-20.json
@@ -0,0 +1,11 @@
+{
+  "changes": [
+    {
+      "packageName": "office-ui-fabric-react",
+      "comment": "FocusZone: redoing the \"reset alignment on mouse down\" change in a less intrusive manner, with test coverage.",
+      "type": "patch"
+    }
+  ],
+  "packageName": "office-ui-fabric-react",
+  "email": "dzearing@microsoft.com"
+}
\ No newline at end of file
diff --git a/packages/office-ui-fabric-react/src/components/FocusZone/FocusZone.test.tsx b/packages/office-ui-fabric-react/src/components/FocusZone/FocusZone.test.tsx
index d5972db64ea2c6..585a3a14e83ad8 100644
--- a/packages/office-ui-fabric-react/src/components/FocusZone/FocusZone.test.tsx
+++ b/packages/office-ui-fabric-react/src/components/FocusZone/FocusZone.test.tsx
@@ -619,6 +619,91 @@ describe('FocusZone', () => {
     expect(lastFocusedElement).toBe(buttonA);
   });
 
+  it('can reset alignment on mouse down', () => {
+    const component = ReactTestUtils.renderIntoDocument(
+      <div { ...{ onFocusCapture: _onFocus } }>
+        <FocusZone>
+          <button className='a'>a</button>
+          <button className='b'>b</button>
+          <button className='c'>c</button>
+          <button className='d'>d</button>
+        </FocusZone>
+      </div>
+    );
+
+    const focusZone = ReactDOM.findDOMNode(component as React.ReactInstance).firstChild as Element;
+    const buttonA = focusZone.querySelector('.a') as HTMLElement;
+    const buttonB = focusZone.querySelector('.b') as HTMLElement;
+    const buttonC = focusZone.querySelector('.c') as HTMLElement;
+    const buttonD = focusZone.querySelector('.d') as HTMLElement;
+
+    // Set up a grid like so:
+    // A B
+    // C D
+    setupElement(buttonA, {
+      clientRect: {
+        top: 0,
+        bottom: 20,
+        left: 0,
+        right: 20
+      }
+    });
+
+    setupElement(buttonB, {
+      clientRect: {
+        top: 0,
+        bottom: 20,
+        left: 20,
+        right: 40
+      }
+    });
+
+    setupElement(buttonC, {
+      clientRect: {
+        top: 20,
+        bottom: 40,
+        left: 0,
+        right: 20
+      }
+    });
+
+    setupElement(buttonD, {
+      clientRect: {
+        top: 20,
+        bottom: 40,
+        left: 20,
+        right: 40
+      }
+    });
+
+    // Focus the first button.
+    ReactTestUtils.Simulate.focus(buttonA);
+    expect(lastFocusedElement).toBe(buttonA);
+
+    // Pressing up should stay on a.
+    ReactTestUtils.Simulate.keyDown(focusZone, { which: KeyCodes.up });
+    expect(lastFocusedElement).toBe(buttonA);
+
+    // Pressing left should stay on a.
+    ReactTestUtils.Simulate.keyDown(focusZone, { which: KeyCodes.left });
+    expect(lastFocusedElement).toBe(buttonA);
+
+    // Pressing right should go to b.
+    ReactTestUtils.Simulate.keyDown(focusZone, { which: KeyCodes.right });
+    expect(lastFocusedElement).toBe(buttonB);
+
+    // Pressing down should go to d.
+    ReactTestUtils.Simulate.keyDown(focusZone, { which: KeyCodes.down });
+    expect(lastFocusedElement).toBe(buttonD);
+
+    // Mousing down on a should reset alignment to a.
+    ReactTestUtils.Simulate.mouseDown(focusZone, { target: buttonA });
+
+    // Pressing down should go to c.
+    ReactTestUtils.Simulate.keyDown(focusZone, { which: KeyCodes.down });
+    expect(lastFocusedElement).toBe(buttonC);
+  });
+
   it('can use arrows bidirectionally with data-no-horizontal-wrap and data-no-vertical-wrap', () => {
     const component = ReactTestUtils.renderIntoDocument(
       <div { ...{ onFocusCapture: _onFocus } }>
diff --git a/packages/office-ui-fabric-react/src/components/FocusZone/FocusZone.tsx b/packages/office-ui-fabric-react/src/components/FocusZone/FocusZone.tsx
index 6823e02c0e7b1d..030ee51140bb4b 100644
--- a/packages/office-ui-fabric-react/src/components/FocusZone/FocusZone.tsx
+++ b/packages/office-ui-fabric-react/src/components/FocusZone/FocusZone.tsx
@@ -259,7 +259,7 @@ export class FocusZone extends BaseComponent<IFocusZoneProps, {}> implements IFo
       target = path.pop() as HTMLElement;
 
       if (target && isElementTabbable(target)) {
-        this._setActiveElement(target);
+        this._setActiveElement(target, true);
       }
 
       if (isElementFocusZone(target)) {
@@ -269,7 +269,7 @@ export class FocusZone extends BaseComponent<IFocusZoneProps, {}> implements IFo
     }
   }
 
-  private _setActiveElement(element: HTMLElement): void {
+  private _setActiveElement(element: HTMLElement, forceAlignemnt?: boolean): void {
     const previousActiveElement = this._activeElement;
 
     this._activeElement = element;
@@ -283,7 +283,7 @@ export class FocusZone extends BaseComponent<IFocusZoneProps, {}> implements IFo
     }
 
     if (this._activeElement) {
-      if (!this._focusAlignment) {
+      if (!this._focusAlignment || forceAlignemnt) {
         this._setFocusAlignment(element, true, true);
       }