diff --git a/apps/vr-tests-react-components/src/stories/Positioning.stories.tsx b/apps/vr-tests-react-components/src/stories/Positioning.stories.tsx
index 37034935a7d596..69dcb49de2b1d3 100644
--- a/apps/vr-tests-react-components/src/stories/Positioning.stories.tsx
+++ b/apps/vr-tests-react-components/src/stories/Positioning.stories.tsx
@@ -1084,6 +1084,63 @@ const ScrollJumpContext = () => {
   );
 };
 
+const MultiScrollParent = () => {
+  const { targetRef, containerRef } = usePositioning({});
+  const scrollContainerRef = React.useRef<HTMLDivElement>(null);
+
+  const scroll = () => {
+    if (scrollContainerRef.current) {
+      scrollContainerRef.current.scrollBy({ top: 100 });
+    }
+  };
+
+  return (
+    <>
+      <span>The popover should stay attached to the trigger</span>
+      <button id="scroll" onClick={scroll}>
+        scroll
+      </button>
+      <div
+        ref={scrollContainerRef}
+        style={{
+          border: '2px dashed green',
+          height: 300,
+          width: 400,
+          overflow: 'auto',
+          display: 'grid',
+          gridTemplateColumns: '350px auto',
+          gridTemplateRows: '800px',
+        }}
+      >
+        <div style={{ position: 'relative' }}>
+          <div
+            style={{
+              overflow: 'auto',
+              border: '2px dashed red',
+              position: 'absolute',
+              top: 150,
+              left: 100,
+              padding: 20,
+            }}
+          >
+            <button id="target" ref={targetRef}>
+              Trigger
+            </button>
+          </div>
+        </div>
+        <div
+          style={{
+            backgroundImage: 'linear-gradient(to bottom, #ffffff, #b9b9b9, #777777, #3b3b3b, #000000)',
+          }}
+        />
+      </div>
+      <div ref={containerRef} style={{ border: '2px solid blue', padding: 20, backgroundColor: 'white' }}>
+        Popover
+      </div>
+    </>
+  );
+};
+
 storiesOf('Positioning', module)
   .addDecorator(story => (
     <div
@@ -1161,7 +1218,12 @@ storiesOf('Positioning', module)
     'disable CSS transform with position fixed',
     () => <PositionAndAlignProps positionFixed useTransform={false} />,
     { includeRtl: true },
-  );
+  )
+  .addStory('Multiple scroll parents', () => (
+    <StoryWright steps={new Steps().click('#scroll').snapshot('container attached to target').end()}>
+      <MultiScrollParent />
+    </StoryWright>
+  ));
 
 storiesOf('Positioning (no decorator)', module)
   .addStory('scroll jumps', () => (
diff --git a/change/@fluentui-react-positioning-938da831-77f1-4eaa-9251-f9b1fc6c6d7a.json b/change/@fluentui-react-positioning-938da831-77f1-4eaa-9251-f9b1fc6c6d7a.json
new file mode 100644
index 00000000000000..e0ebd7a47d3430
--- /dev/null
+++ b/change/@fluentui-react-positioning-938da831-77f1-4eaa-9251-f9b1fc6c6d7a.json
@@ -0,0 +1,7 @@
+{
+  "type": "patch",
+  "comment": "fix: Consider all parents as scroll parents",
+  "packageName": "@fluentui/react-positioning",
+  "email": "lingfan.gao@microsoft.com",
+  "dependentChangeType": "patch"
+}
diff --git a/packages/react-components/react-positioning/src/createPositionManager.ts b/packages/react-components/react-positioning/src/createPositionManager.ts
index 347a164131f4ca..0b7a354162874f 100644
--- a/packages/react-components/react-positioning/src/createPositionManager.ts
+++ b/packages/react-components/react-positioning/src/createPositionManager.ts
@@ -1,8 +1,9 @@
 import { computePosition } from '@floating-ui/dom';
 import type { Middleware, Placement, Strategy } from '@floating-ui/dom';
 import type { PositionManager, TargetElement } from './types';
-import { debounce, writeArrowUpdates, writeContainerUpdates, getScrollParent } from './utils';
+import { debounce, writeArrowUpdates, writeContainerUpdates } from './utils';
 import { isHTMLElement } from '@fluentui/react-utilities';
+import { listScrollParents } from './utils/listScrollParents';
 
 interface PositionManagerOptions {
   /**
@@ -67,9 +68,9 @@ export function createPositionManager(options: PositionManagerOptions): Position
     }
 
     if (isFirstUpdate) {
-      scrollParents.add(getScrollParent(container));
+      listScrollParents(container).forEach(scrollParent => scrollParents.add(scrollParent));
       if (isHTMLElement(target)) {
-        scrollParents.add(getScrollParent(target));
+        listScrollParents(target).forEach(scrollParent => scrollParents.add(scrollParent));
       }
 
       scrollParents.forEach(scrollParent => {
@@ -127,6 +128,7 @@ export function createPositionManager(options: PositionManagerOptions): Position
     scrollParents.forEach(scrollParent => {
       scrollParent.removeEventListener('scroll', updatePosition);
     });
+    scrollParents.clear();
   };
 
   if (targetWindow) {
diff --git a/packages/react-components/react-positioning/src/utils/listScrollParents.test.ts b/packages/react-components/react-positioning/src/utils/listScrollParents.test.ts
new file mode 100644
index 00000000000000..865fd02a38c5a0
--- /dev/null
+++ b/packages/react-components/react-positioning/src/utils/listScrollParents.test.ts
@@ -0,0 +1,30 @@
+import { listScrollParents } from './listScrollParents';
+
+describe('listScrollParents', () => {
+  beforeEach(() => {
+    document.body.innerHTML = '';
+  });
+
+  const createScrollParent = () => {
+    const el = document.createElement('div');
+    el.style.overflow = 'auto';
+    return el;
+  };
+
+  it('should return all scroll parents include and up to body', () => {
+    const start = document.createElement('div');
+    const scrollParent1 = createScrollParent();
+    const scrollParent2 = createScrollParent();
+
+    scrollParent1.appendChild(start);
+    scrollParent2.appendChild(scrollParent1);
+    document.body.append(scrollParent2);
+
+    const scrollParents = listScrollParents(start);
+
+    expect(scrollParents.length).toBe(3);
+    expect(scrollParents).toContain(scrollParent1);
+    expect(scrollParents).toContain(scrollParent2);
+    expect(scrollParents).toContain(document.body);
+  });
+});
diff --git a/packages/react-components/react-positioning/src/utils/listScrollParents.ts b/packages/react-components/react-positioning/src/utils/listScrollParents.ts
new file mode 100644
index 00000000000000..afc08a00aee67f
--- /dev/null
+++ b/packages/react-components/react-positioning/src/utils/listScrollParents.ts
@@ -0,0 +1,20 @@
+import { getScrollParent } from './getScrollParent';
+
+export function listScrollParents(node: HTMLElement): HTMLElement[] {
+  const scrollParents: HTMLElement[] = [];
+
+  let cur: HTMLElement | null = node;
+  while (cur) {
+    const scrollParent = getScrollParent(cur);
+
+    if (node.ownerDocument.body === scrollParent) {
+      scrollParents.push(scrollParent);
+      break;
+    }
+
+    scrollParents.push(scrollParent);
+    cur = scrollParent;
+  }
+
+  return scrollParents;
+}