diff --git a/change/@fluentui-react-894d0bed-f8c8-4b12-a243-6a8d22912afe.json b/change/@fluentui-react-894d0bed-f8c8-4b12-a243-6a8d22912afe.json
new file mode 100644
index 00000000000000..3df77f55fbded5
--- /dev/null
+++ b/change/@fluentui-react-894d0bed-f8c8-4b12-a243-6a8d22912afe.json
@@ -0,0 +1,7 @@
+{
+  "type": "minor",
+  "comment": "Fix: Combobox if value is controlled, we should not update state",
+  "packageName": "@fluentui/react",
+  "email": "mgodbolt@microsoft.com",
+  "dependentChangeType": "patch"
+}
diff --git a/packages/react/src/components/Autofill/Autofill.tsx b/packages/react/src/components/Autofill/Autofill.tsx
index 87a2cdd6f84705..f4b4978e5b54c8 100644
--- a/packages/react/src/components/Autofill/Autofill.tsx
+++ b/packages/react/src/components/Autofill/Autofill.tsx
@@ -326,12 +326,16 @@ export class Autofill extends React.Component<IAutofillProps, IAutofillState> im
     }
 
     // eslint-disable-next-line deprecation/deprecation
-    const { onInputChange, onInputValueChange } = this.props;
+    const { onInputChange, onInputValueChange, updateValueInWillReceiveProps } = this.props;
     if (onInputChange) {
       newValue = onInputChange?.(newValue, composing) || '';
     }
 
-    this.setState({ inputValue: newValue }, () => onInputValueChange?.(newValue, composing));
+    // if value is controlled in updateValueInWillReceiveProps, then we should not update the value in state now
+    // https://github.com/microsoft/fluentui/issues/18499
+    updateValueInWillReceiveProps
+      ? onInputValueChange?.(newValue, composing)
+      : this.setState({ inputValue: newValue }, () => onInputValueChange?.(newValue, composing));
   };
 
   private _getDisplayValue(): string {