diff --git a/change/@fluentui-react-positioning-4bd82184-0e7b-46e8-a681-c87900b25568.json b/change/@fluentui-react-positioning-4bd82184-0e7b-46e8-a681-c87900b25568.json
new file mode 100644
index 0000000000000..5631d40cf1cde
--- /dev/null
+++ b/change/@fluentui-react-positioning-4bd82184-0e7b-46e8-a681-c87900b25568.json
@@ -0,0 +1,7 @@
+{
+  "type": "patch",
+  "comment": "fix(createPositionManager): computePosition should not apply styles after destruction",
+  "packageName": "@fluentui/react-positioning",
+  "email": "lingfangao@hotmail.com",
+  "dependentChangeType": "patch"
+}
diff --git a/packages/react-components/react-positioning/src/createPositionManager.ts b/packages/react-components/react-positioning/src/createPositionManager.ts
index 1dcde740ee90e..1671c0ada2fd0 100644
--- a/packages/react-components/react-positioning/src/createPositionManager.ts
+++ b/packages/react-components/react-positioning/src/createPositionManager.ts
@@ -37,6 +37,7 @@ interface PositionManagerOptions {
  */
 export function createPositionManager(options: PositionManagerOptions): PositionManager {
   const { container, target, arrow, strategy, middleware, placement } = options;
+  let isDestroyed = false;
   if (!target || !container) {
     return {
       updatePosition: () => undefined,
@@ -52,7 +53,13 @@ export function createPositionManager(options: PositionManagerOptions): Position
   // Without this scroll jumps can occur when the element is rendered initially and receives focus
   Object.assign(container.style, { position: 'fixed', left: 0, top: 0, margin: 0 });
 
-  let forceUpdate = () => {
+  const forceUpdate = () => {
+    // debounced update can still occur afterwards
+    // early return to avoid memory leaks
+    if (isDestroyed) {
+      return;
+    }
+
     if (isFirstUpdate) {
       scrollParents.add(getScrollParent(container));
       if (target instanceof HTMLElement) {
@@ -69,6 +76,12 @@ export function createPositionManager(options: PositionManagerOptions): Position
     Object.assign(container.style, { position: strategy });
     computePosition(target, container, { placement, middleware, strategy })
       .then(({ x, y, middlewareData, placement: computedPlacement }) => {
+        // Promise can still resolve after destruction
+        // early return to avoid applying outdated position
+        if (isDestroyed) {
+          return;
+        }
+
         writeArrowUpdates({ arrow, middlewareData });
         writeContainerUpdates({
           container,
@@ -97,9 +110,7 @@ export function createPositionManager(options: PositionManagerOptions): Position
   const updatePosition = debounce(() => forceUpdate());
 
   const dispose = () => {
-    // debounced update can still occur afterwards
-    // so destroy the reference to forceUpdate
-    forceUpdate = () => null;
+    isDestroyed = true;
 
     if (targetWindow) {
       targetWindow.removeEventListener('scroll', updatePosition);