diff --git a/change/@fluentui-react-2a9784d7-e2d3-40b7-93ae-e6b94ca7e231.json b/change/@fluentui-react-2a9784d7-e2d3-40b7-93ae-e6b94ca7e231.json
new file mode 100644
index 0000000000000..4fa624908bce7
--- /dev/null
+++ b/change/@fluentui-react-2a9784d7-e2d3-40b7-93ae-e6b94ca7e231.json
@@ -0,0 +1,7 @@
+{
+  "type": "patch",
+  "comment": "fix: Dropdown no longer sets incorrect and unnecessary aria-activedescendant",
+  "packageName": "@fluentui/react",
+  "email": "sarah.higley@microsoft.com",
+  "dependentChangeType": "patch"
+}
diff --git a/packages/react/src/components/Dropdown/Dropdown.base.tsx b/packages/react/src/components/Dropdown/Dropdown.base.tsx
index ab9a248d66a56..07b78fed7c4b4 100644
--- a/packages/react/src/components/Dropdown/Dropdown.base.tsx
+++ b/packages/react/src/components/Dropdown/Dropdown.base.tsx
@@ -332,11 +332,6 @@ class DropdownInternal extends React.Component<IDropdownInternalProps, IDropdown
     const disabled = this._isDisabled();
 
     const errorMessageId = id + '-errorMessage';
-    const ariaActiveDescendant = disabled
-      ? undefined
-      : isOpen && selectedIndices.length === 1 && selectedIndices[0] >= 0
-      ? this._listId + selectedIndices[0]
-      : undefined;
 
     this._classNames = getClassNames(propStyles, {
       theme,
@@ -373,7 +368,6 @@ class DropdownInternal extends React.Component<IDropdownInternalProps, IDropdown
           aria-label={ariaLabel}
           aria-labelledby={label && !ariaLabel ? mergeAriaAttributeValues(this._labelId, this._optionId) : undefined}
           aria-describedby={hasErrorMessage ? this._id + '-errorMessage' : undefined}
-          aria-activedescendant={ariaActiveDescendant}
           aria-required={required}
           aria-disabled={disabled}
           aria-controls={isOpen ? this._listId : undefined}
diff --git a/packages/react/src/components/Dropdown/__snapshots__/Dropdown.test.tsx.snap b/packages/react/src/components/Dropdown/__snapshots__/Dropdown.test.tsx.snap
index 13154c58308cb..81d8afd52c5fd 100644
--- a/packages/react/src/components/Dropdown/__snapshots__/Dropdown.test.tsx.snap
+++ b/packages/react/src/components/Dropdown/__snapshots__/Dropdown.test.tsx.snap
@@ -869,7 +869,6 @@ exports[`Dropdown multi-select Renders correctly when open 1`] = `
       class="ms-Dropdown-container"
     >
       <div
-        aria-activedescendant="Dropdown0-list1"
         aria-controls="Dropdown0-list"
         aria-expanded="true"
         aria-haspopup="listbox"
@@ -1224,7 +1223,6 @@ exports[`Dropdown single-select Renders correctly when open 1`] = `
       class="ms-Dropdown-container"
     >
       <div
-        aria-activedescendant="Dropdown0-list1"
         aria-controls="Dropdown0-list"
         aria-expanded="true"
         aria-haspopup="listbox"