diff --git a/autogen/oai/anthropic.py b/autogen/oai/anthropic.py
index 7bb4608bd258..16a8c5d01bc0 100644
--- a/autogen/oai/anthropic.py
+++ b/autogen/oai/anthropic.py
@@ -94,13 +94,13 @@ def __init__(self, **kwargs: Any):
             self._api_key = os.getenv("ANTHROPIC_API_KEY")
 
         if not self._aws_access_key:
-            self._aws_access_key = os.getenv("AWS_ACCESS_KEY")
+            self._aws_access_key = os.getenv("AWS_ACCESS_KEY_ID")
 
         if not self._aws_secret_key:
-            self._aws_secret_key = os.getenv("AWS_SECRET_KEY")
+            self._aws_secret_key = os.getenv("AWS_SECRET_ACCESS_KEY")
 
         if not self._aws_region:
-            self._aws_region = os.getenv("AWS_REGION")
+            self._aws_region = os.getenv("AWS_DEFAULT_REGION")
 
         if self._api_key is None and (
             self._aws_access_key is None or self._aws_secret_key is None or self._aws_region is None
diff --git a/autogen/oai/bedrock.py b/autogen/oai/bedrock.py
index 7894781e3ee5..a07073eef299 100644
--- a/autogen/oai/bedrock.py
+++ b/autogen/oai/bedrock.py
@@ -58,16 +58,16 @@ def __init__(self, **kwargs: Any):
         self._aws_profile_name = kwargs.get("aws_profile_name", None)
 
         if not self._aws_access_key:
-            self._aws_access_key = os.getenv("AWS_ACCESS_KEY")
+            self._aws_access_key = os.getenv("AWS_ACCESS_KEY_ID")
 
         if not self._aws_secret_key:
-            self._aws_secret_key = os.getenv("AWS_SECRET_KEY")
+            self._aws_secret_key = os.getenv("AWS_SECRET_ACCESS_KEY")
 
         if not self._aws_session_token:
             self._aws_session_token = os.getenv("AWS_SESSION_TOKEN")
 
         if not self._aws_region:
-            self._aws_region = os.getenv("AWS_REGION")
+            self._aws_region = os.getenv("AWS_DEFAULT_REGION")
 
         if self._aws_region is None:
             raise ValueError("Region is required to use the Amazon Bedrock API.")
diff --git a/test/oai/test_anthropic.py b/test/oai/test_anthropic.py
index 53926dbd18d6..8c275e33cb4e 100644
--- a/test/oai/test_anthropic.py
+++ b/test/oai/test_anthropic.py
@@ -50,10 +50,10 @@ def anthropic_client():
 @pytest.mark.skipif(skip, reason=reason)
 def test_initialization_missing_api_key():
     os.environ.pop("ANTHROPIC_API_KEY", None)
-    os.environ.pop("AWS_ACCESS_KEY", None)
-    os.environ.pop("AWS_SECRET_KEY", None)
+    os.environ.pop("AWS_ACCESS_KEY_ID", None)
+    os.environ.pop("AWS_SECRET_ACCESS_KEY", None)
     os.environ.pop("AWS_SESSION_TOKEN", None)
-    os.environ.pop("AWS_REGION", None)
+    os.environ.pop("AWS_DEFAULT_REGION", None)
     with pytest.raises(ValueError, match="API key or AWS credentials are required to use the Anthropic API."):
         AnthropicClient()