diff --git a/marimo/_config/packages.py b/marimo/_config/packages.py
index aea4ddf5454..f7bb0427bc2 100644
--- a/marimo/_config/packages.py
+++ b/marimo/_config/packages.py
@@ -14,6 +14,11 @@
 def infer_package_manager() -> PackageManagerKind:
     """Infer the package manager from the current project."""
 
+    # `uv run` sets `UV` to the uv executable path
+    # https://github.com/astral-sh/uv/issues/8775
+    if os.environ.get("UV") is not None:
+        return "uv"
+
     try:
         # Get the project root by looking for common project files
         current_dir = Path.cwd()
diff --git a/tests/_config/test_config_packages.py b/tests/_config/test_config_packages.py
index 6548a2b8598..acb48259cff 100644
--- a/tests/_config/test_config_packages.py
+++ b/tests/_config/test_config_packages.py
@@ -78,6 +78,8 @@ def test_infer_package_manager_from_lockfile(mock_cwd: Path):
     ({"pixi.toml": ""}, {}, {}, "pixi"),
     # Test fallback to pip
     ({}, {}, {}, "pip"),
+    # Test fallback to uv when running inside `uv run` / `uvx`
+    ({}, {"UV": "/usr/bin/uv"}, {}, "uv"),
 ]
 
 if sys.platform != "win32":