diff --git a/lib/internal/Magento/Framework/Interception/PluginList/PluginList.php b/lib/internal/Magento/Framework/Interception/PluginList/PluginList.php
index 2f86c8703dea5..3553e29f8a76b 100644
--- a/lib/internal/Magento/Framework/Interception/PluginList/PluginList.php
+++ b/lib/internal/Magento/Framework/Interception/PluginList/PluginList.php
@@ -217,7 +217,11 @@ protected function _loadScopedData()
             }
             $this->_scopePriorityScheme[] = $scope;
 
-            $cacheId = implode('|', $this->_scopePriorityScheme) . "|" . $this->_cacheId;
+            // Sort scopes alphabetically to ensure cache ID is deterministic
+            // regardless of processing order (fixes mismatch with compile-time generation)
+            $sortedScheme = array_values($this->_scopePriorityScheme);
+            sort($sortedScheme);
+            $cacheId = implode('|', $sortedScheme) . "|" . $this->_cacheId;
             $configData = $this->configLoader->load($cacheId);
 
             if ($configData) {
diff --git a/lib/internal/Magento/Framework/Interception/PluginListGenerator.php b/lib/internal/Magento/Framework/Interception/PluginListGenerator.php
index 0153ee92a8062..c7d9ccdd1f17c 100644
--- a/lib/internal/Magento/Framework/Interception/PluginListGenerator.php
+++ b/lib/internal/Magento/Framework/Interception/PluginListGenerator.php
@@ -93,7 +93,11 @@ public function write(array $scopes): void
                 if (false === in_array($scope, $this->scopePriorityScheme, true)) {
                     $this->scopePriorityScheme[] = $scope;
                 }
-                $cacheId = implode('|', $this->scopePriorityScheme) . "|" . $this->cacheId;
+                // Sort scopes alphabetically to ensure cache ID is deterministic
+                // regardless of processing order (fixes mismatch with runtime loading)
+                $sortedScheme = array_values($this->scopePriorityScheme);
+                sort($sortedScheme);
+                $cacheId = implode('|', $sortedScheme) . "|" . $this->cacheId;
                 [
                     $virtualTypes,
                     $this->scopePriorityScheme,