diff --git a/.changeset/breezy-hounds-doubt.md b/.changeset/breezy-hounds-doubt.md
new file mode 100644
index 0000000000..b34224f8f7
--- /dev/null
+++ b/.changeset/breezy-hounds-doubt.md
@@ -0,0 +1,5 @@
+---
+'@lynx-js/gesture-runtime': patch
+---
+
+Optimize gesture callbacks and relationships to prevent unnecessary gesture registration and rerenders.
diff --git a/packages/lynx/gesture-runtime/__test__/gesture-config.test.ts b/packages/lynx/gesture-runtime/__test__/gesture-config.test.ts
index 9c32c4ad43..9ccb8d8e3e 100644
--- a/packages/lynx/gesture-runtime/__test__/gesture-config.test.ts
+++ b/packages/lynx/gesture-runtime/__test__/gesture-config.test.ts
@@ -221,5 +221,37 @@ describe('Gesture Configuration', () => {
       pan.enabled(false);
       expect(pan.execId).toBe(2);
     });
+
+    test('execId should not increment on identical config change', () => {
+      const pan = new PanGesture();
+      expect(pan.execId).toBe(0);
+
+      pan.minDistance(10);
+      expect(pan.execId).toBe(1);
+
+      // Re-applying same config should not increment
+      pan.minDistance(10);
+      expect(pan.execId).toBe(1);
+
+      pan.enabled(false);
+      expect(pan.execId).toBe(2);
+
+      // Re-applying same config should not increment
+      pan.enabled(false);
+      expect(pan.execId).toBe(2);
+    });
+
+    test('execId should not increment when setting duplicate relationships', () => {
+      const pan1 = new PanGesture();
+      const tap1 = new TapGesture();
+      expect(pan1.execId).toBe(0);
+
+      pan1.externalSimultaneous(tap1);
+      expect(pan1.execId).toBe(1);
+
+      // Setting same relationship should not increment
+      pan1.externalSimultaneous(tap1);
+      expect(pan1.execId).toBe(1);
+    });
   });
 });
diff --git a/packages/lynx/gesture-runtime/__test__/gesture-relations.test.tsx b/packages/lynx/gesture-runtime/__test__/gesture-relations.test.tsx
index cc8a397d45..5788cd7aff 100644
--- a/packages/lynx/gesture-runtime/__test__/gesture-relations.test.tsx
+++ b/packages/lynx/gesture-runtime/__test__/gesture-relations.test.tsx
@@ -188,4 +188,61 @@ describe('Gesture Relations and Edge Cases', () => {
     expect(composed.gestures[0]).toBe(pan);
     expect(composed.gestures[1]).toBe(tap);
   });
+  test('should deduplicate gestures in externalWaitFor when using ComposedGesture', () => {
+    const pan = new PanGesture();
+    const tap = new TapGesture();
+
+    pan.externalWaitFor(tap);
+    const initialExecId = pan.execId;
+
+    // Passing a composed gesture that contains the current gesture `pan`,
+    // an already existing gesture `tap`, and a duplicate gesture `tap` again.
+    // Also include a new gesture `longPress`.
+    const longPress = new LongPressGesture();
+    const composed = Gesture.Simultaneous(pan, tap, tap, longPress);
+
+    pan.externalWaitFor(composed);
+
+    // Only `longPress` should be added. `pan` is self, `tap` is existing, the second `tap` is duplicate.
+    expect(pan.waitFor).toHaveLength(2);
+    expect(pan.waitFor).toContain(tap);
+    expect(pan.waitFor).toContain(longPress);
+    expect(pan.execId).toBe(initialExecId + 1);
+  });
+
+  test('should deduplicate gestures in externalSimultaneous when using ComposedGesture', () => {
+    const pan = new PanGesture();
+    const tap = new TapGesture();
+
+    pan.externalSimultaneous(tap);
+    const initialExecId = pan.execId;
+
+    const longPress = new LongPressGesture();
+    const composed = Gesture.Race(pan, tap, tap, longPress);
+
+    pan.externalSimultaneous(composed);
+
+    expect(pan.simultaneousWith).toHaveLength(2);
+    expect(pan.simultaneousWith).toContain(tap);
+    expect(pan.simultaneousWith).toContain(longPress);
+    expect(pan.execId).toBe(initialExecId + 1);
+  });
+
+  test('should deduplicate gestures in externalContinueWith when using ComposedGesture', () => {
+    const pan = new PanGesture();
+    const tap = new TapGesture();
+
+    pan.externalContinueWith(tap);
+    const initialExecId = pan.execId;
+
+    const longPress = new LongPressGesture();
+    const composed = Gesture.Exclusive(pan, tap, tap, longPress);
+
+    pan.externalContinueWith(composed);
+
+    expect(pan.continueWith).toHaveLength(2);
+    expect(pan.continueWith).toContain(tap);
+    expect(pan.continueWith).toContain(longPress);
+    expect(pan.execId).toBe(initialExecId + 1);
+  });
 });
diff --git a/packages/lynx/gesture-runtime/__test__/useMainThreadMemoizedFn.test.tsx b/packages/lynx/gesture-runtime/__test__/useMainThreadMemoizedFn.test.tsx
new file mode 100644
index 0000000000..d173463c15
--- /dev/null
+++ b/packages/lynx/gesture-runtime/__test__/useMainThreadMemoizedFn.test.tsx
@@ -0,0 +1,109 @@
+// Copyright 2025 The Lynx Authors. All rights reserved.
+// Licensed under the Apache License Version 2.0 that can be found in the
+// LICENSE file in the root directory of this source tree.
+
+import { useState } from '@lynx-js/react';
+import { act, render } from '@lynx-js/react/testing-library';
+import { beforeEach, describe, expect, test, vi } from 'vitest';
+
+import { useMainThreadMemoizedFn } from '../src/utils/useMainThreadMemoizedFn.js';
+
+describe('useMainThreadMemoizedFn', () => {
+  beforeEach(() => {
+    vi.clearAllMocks();
+  });
+
+  test('should return a stable reference but execute the latest logic on background thread', async () => {
+    let memoizedFnRef: any;
+    let _setCount: any;
+
+    const App = () => {
+      const [count, setCount] = useState(0);
+      _setCount = setCount;
+
+      const memoizedFn = useMainThreadMemoizedFn(() => {
+        'main thread';
+        return count;
+      });
+
+      memoizedFnRef = memoizedFn;
+
+      return <view></view>;
+    };
+
+    render(<App />);
+
+    const fn1 = memoizedFnRef;
+    let res = globalThis.runWorklet(fn1, []);
+    expect(res).toBe(0);
+
+    await act(() => {
+      _setCount(1);
+    });
+
+    const fn2 = memoizedFnRef;
+    expect(fn1).toBe(fn2); // Stable reference!
+
+    res = globalThis.runWorklet(fn2, []);
+    expect(res).toBe(1); // Latest logic!
+  });
+
+  test('should return a stable reference but execute the latest logic on main thread', async () => {
+    let memoizedFnRef: any;
+    let _setCount: any;
+
+    const App = () => {
+      const [count, setCount] = useState(0);
+      _setCount = setCount;
+
+      const memoizedFn = useMainThreadMemoizedFn(() => {
+        'main thread';
+        return count;
+      });
+
+      memoizedFnRef = memoizedFn;
+
+      return <view></view>;
+    };
+
+    await act(() => {
+      render(<App />, {
+        enableMainThread: true,
+        enableBackgroundThread: true,
+      });
+    });
+
+    const fn1 = memoizedFnRef;
+    let res = globalThis.runWorklet(fn1, []);
+    expect(res).toBe(0);
+
+    await act(() => {
+      _setCount(1);
+    });
+
+    const fn2 = memoizedFnRef;
+    expect(fn1).toBe(fn2); // Stable reference!
+
+    res = globalThis.runWorklet(fn2, []);
+    expect(res).toBe(1); // Latest logic!
+  });
+
+  test('should pass arguments properly and return value', () => {
+    let memoizedFnRef: any;
+
+    const App = () => {
+      const memoizedFn = useMainThreadMemoizedFn((a: number, b: number) => {
+        'main thread';
+        return a + b;
+      });
+
+      memoizedFnRef = memoizedFn;
+
+      return <view></view>;
+    };
+
+    render(<App />);
+
+    expect(globalThis.runWorklet(memoizedFnRef, [2, 3])).toBe(5);
+  });
+});
diff --git a/packages/lynx/gesture-runtime/src/baseGesture.ts b/packages/lynx/gesture-runtime/src/baseGesture.ts
index 5c4b23b0b2..4ec2b5aa4d 100644
--- a/packages/lynx/gesture-runtime/src/baseGesture.ts
+++ b/packages/lynx/gesture-runtime/src/baseGesture.ts
@@ -141,8 +141,10 @@ abstract class BaseGesture<
   }
 
   updateConfig = (k: string, v: unknown): this => {
-    this.execId += 1;
-    (this.config as Record<string, unknown>)[k] = v;
+    if ((this.config as Record<string, unknown>)[k] !== v) {
+      this.execId += 1;
+      (this.config as Record<string, unknown>)[k] = v;
+    }
     return this;
   };
 
@@ -150,7 +152,9 @@ abstract class BaseGesture<
     k: keyof typeof this.callbacks,
     cb: GestureCallback<TEvent>,
   ): this => {
-    this.execId += 1;
+    if (!(k in this.callbacks)) {
+      this.execId += 1;
+    }
     // Wrapped callback is compatible with GestureCallback<TEvent> at runtime
     this.callbacks[k] = wrapCallback<TEvent>(
       cb,
@@ -189,51 +193,43 @@ abstract class BaseGesture<
     return this.updateCallback('onTouchesCancel', cb);
   };
 
-  externalWaitFor = (gesture: GestureKind): this => {
+  private addRelation = (
+    gesture: GestureKind,
+    relationArrayName: 'waitFor' | 'simultaneousWith' | 'continueWith',
+  ): this => {
     if (gesture === this) {
       return this;
     }
-    this.execId += 1;
-    if (gesture.type === GestureTypeInner.COMPOSED) {
-      this.waitFor = this.waitFor.concat(gesture.toGestureArray());
-    } else {
-      this.waitFor.push(
-        gesture as BaseGesture<BaseGestureConfig, GestureChangeEvent>,
-      );
+    const gestures = gesture.type === GestureTypeInner.COMPOSED
+      ? gesture.toGestureArray()
+      : [gesture as BaseGesture<BaseGestureConfig, GestureChangeEvent>];
+    const relationArray = this[relationArrayName];
+    const existingIds = new Set(relationArray.map(g => g.id));
+    const newGestures = gestures.filter(g => {
+      // Filter out self
+      if ((g as unknown) === this || g.id === this.id) return false;
+      // Filter out existing and dedupe
+      if (existingIds.has(g.id)) return false;
+      existingIds.add(g.id);
+      return true;
+    });
+    if (newGestures.length > 0) {
+      this.execId += 1;
+      this[relationArrayName] = relationArray.concat(newGestures);
     }
     return this;
   };
 
+  externalWaitFor = (gesture: GestureKind): this => {
+    return this.addRelation(gesture, 'waitFor');
+  };
+
   externalSimultaneous = (gesture: GestureKind): this => {
-    if (gesture === this) {
-      return this;
-    }
-    this.execId += 1;
-    if (gesture.type === GestureTypeInner.COMPOSED) {
-      this.simultaneousWith = this.simultaneousWith.concat(
-        gesture.toGestureArray(),
-      );
-    } else {
-      this.simultaneousWith.push(
-        gesture as BaseGesture<BaseGestureConfig, GestureChangeEvent>,
-      );
-    }
-    return this;
+    return this.addRelation(gesture, 'simultaneousWith');
   };
 
   externalContinueWith = (gesture: GestureKind): this => {
-    if (gesture === this) {
-      return this;
-    }
-    this.execId += 1;
-    if (gesture.type === GestureTypeInner.COMPOSED) {
-      this.continueWith = this.continueWith.concat(gesture.toGestureArray());
-    } else {
-      this.continueWith.push(
-        gesture as BaseGesture<BaseGestureConfig, GestureChangeEvent>,
-      );
-    }
-    return this;
+    return this.addRelation(gesture, 'continueWith');
   };
 
   toGestureArray = (): BaseGesture<BaseGestureConfig, GestureChangeEvent>[] => {
@@ -284,7 +280,9 @@ abstract class ContinuousGesture<
     k: keyof typeof this.callbacks,
     cb: GestureCallback<TEvent>,
   ): this => {
-    this.execId += 1;
+    if (!(k in this.callbacks)) {
+      this.execId += 1;
+    }
     // Wrapped callback is compatible with GestureCallback<TEvent> at runtime
     this.callbacks[k] = wrapCallback<TEvent>(
       cb,
diff --git a/packages/lynx/gesture-runtime/src/utils/useMainThreadMemoizedFn.ts b/packages/lynx/gesture-runtime/src/utils/useMainThreadMemoizedFn.ts
new file mode 100644
index 0000000000..bd6282987c
--- /dev/null
+++ b/packages/lynx/gesture-runtime/src/utils/useMainThreadMemoizedFn.ts
@@ -0,0 +1,64 @@
+// Copyright 2025 The Lynx Authors. All rights reserved.
+// Licensed under the Apache License Version 2.0 that can be found in the
+// LICENSE file in the root directory of this source tree.
+
+import { runOnMainThread, useMainThreadRef, useMemo } from '@lynx-js/react';
+import { runWorkletCtx } from '@lynx-js/react/worklet-runtime/bindings';
+
+type noop = (this: unknown, ...args: unknown[]) => unknown;
+
+type PickFunction<T extends noop> = (
+  this: ThisParameterType<T>,
+  ...args: Parameters<T>
+) => ReturnType<T>;
+
+/**
+ * @internal
+ * Hooks for persistent main thread functions.
+ * It ensures the returned function has a stable reference while always executing the latest logic on the main thread.
+ * @example
+ * ```tsx
+ * const handleScroll = useMainThreadMemoizedFn((e: MainThread.TouchEvent) => {
+ *   'main thread';
+ *   console.log(count); // Access captured variable
+ * });
+ * ```
+ */
+export function useMainThreadMemoizedFn<T extends noop>(fn: T): T {
+  // Create a ref on the main thread to hold the function
+  const fnMTRef = useMainThreadRef<T>(fn);
+
+  // Synchronize the latest function to the main thread ref during render
+  useMemo(() => {
+    if (__MAIN_THREAD__) {
+      /* v8 ignore next 5 */
+      // @ts-expect-error - This is a worklet context, we can directly assign to the ref
+      runWorkletCtx(() => {
+        'main thread';
+        fnMTRef.current = fn;
+      }, []);
+    } else {
+      /* v8 ignore next 4 */
+      void runOnMainThread((latestFn: T) => {
+        'main thread';
+        fnMTRef.current = latestFn;
+      })(fn);
+    }
+  }, [fn]);
+
+  // Return a stable wrapper function
+  const memoizedFn = useMemo<PickFunction<T>>(() => {
+    /* v8 ignore next 10 */
+    return function(this: ThisParameterType<T>, ...args: Parameters<T>) {
+      'main thread';
+      // Call the latest function stored in the ref
+      const currentFn = fnMTRef.current;
+      if (currentFn) {
+        return currentFn.apply(this, args) as ReturnType<T>;
+      }
+      return undefined as ReturnType<T>;
+    };
+  }, []);
+
+  return memoizedFn as unknown as T;
+}
diff --git a/packages/lynx/gesture-runtime/turbo.jsonc b/packages/lynx/gesture-runtime/turbo.jsonc
index 7fbaa86253..2d51bb206d 100644
--- a/packages/lynx/gesture-runtime/turbo.jsonc
+++ b/packages/lynx/gesture-runtime/turbo.jsonc
@@ -4,6 +4,7 @@
   "tasks": {
     "build": {
       "dependsOn": [
+        "//#build",
         "^build",
       ],
       "inputs": [