diff --git a/.changeset/tender-otters-cheat.md b/.changeset/tender-otters-cheat.md
new file mode 100644
index 0000000000..999c06171c
--- /dev/null
+++ b/.changeset/tender-otters-cheat.md
@@ -0,0 +1,5 @@
+---
+"@lynx-js/react": patch
+---
+
+fix: properly cleanup `__DestroyLifetime` listeners and listCallbacks in `snapshotDestroyList`.
diff --git a/packages/react/runtime/__test__/list.test.jsx b/packages/react/runtime/__test__/list.test.jsx
index b08ccbb2cc..3b6eba5114 100644
--- a/packages/react/runtime/__test__/list.test.jsx
+++ b/packages/react/runtime/__test__/list.test.jsx
@@ -443,12 +443,10 @@ describe(`list componentAtIndex`, () => {
     __pendingListUpdates.flush();
 
     a.removeChild(b);
-    expect(() => {
-      elementTree.triggerComponentAtIndex(listRef, 0);
-    }).toThrowErrorMatchingInlineSnapshot(`[Error: componentAtIndex called on removed list]`);
-    expect(() => {
-      elementTree.triggerEnqueueComponent(listRef, 0);
-    }).toThrowErrorMatchingInlineSnapshot(`[Error: enqueueComponent called on removed list]`);
+
+    expect(listRef.componentAtIndex()).toBe(-1);
+    expect(listRef.enqueueComponent()).toBeUndefined();
+    expect(listRef.componentAtIndexes()).toBeUndefined();
   });
 
   it('should reuse and hydrate', () => {
@@ -4409,4 +4407,45 @@ describe('clear __UpdateListCallbacks', () => {
     expect(listElement.enqueueComponent).toBeNull();
     expect(listElement.componentAtIndexes).toBeNull();
   });
+
+  it('should remove __DestroyLifetime listener when list is destroyed via removeChild', () => {
+    const s0 = __SNAPSHOT__(
+      <view>
+        {HOLE}
+      </view>,
+    );
+    const s1 = __SNAPSHOT__(
+      <view>
+        <text>test</text>
+        <list>{HOLE}</list>
+      </view>,
+    );
+
+    const root = new SnapshotInstance(s0);
+    root.ensureElements();
+
+    const a = new SnapshotInstance(s1);
+    root.insertBefore(a);
+
+    expect(lynx.getNative().addEventListener).toHaveBeenCalledWith(
+      '__DestroyLifetime',
+      expect.any(Function),
+    );
+
+    const listElement = a.__elements[3];
+    expect(listElement.componentAtIndex).not.toBeNull();
+    expect(listElement.enqueueComponent).not.toBeNull();
+    expect(listElement.componentAtIndexes).not.toBeNull();
+
+    root.removeChild(a);
+
+    expect(lynx.getNative().removeEventListener).toHaveBeenCalledWith(
+      '__DestroyLifetime',
+      expect.any(Function),
+    );
+
+    expect(listElement.componentAtIndex()).toBe(-1);
+    expect(listElement.enqueueComponent()).toBeUndefined();
+    expect(listElement.componentAtIndexes()).toBeUndefined();
+  });
 });
diff --git a/packages/react/runtime/src/list.ts b/packages/react/runtime/src/list.ts
index 02463cbeb4..1c32d70591 100644
--- a/packages/react/runtime/src/list.ts
+++ b/packages/react/runtime/src/list.ts
@@ -52,9 +52,14 @@ export function componentAtIndexFactory(
   ) => {
     const signMap = gSignMap[listID];
     const recycleMap = gRecycleMap[listID];
+
+    /* v8 ignore start */
     if (!signMap || !recycleMap) {
+      // Theoretically unreachable since snapshotDestroyList clears componentAtIndex with a noop function.
+      // Kept as a safeguard in case the callback is somehow invoked after list removal.
       throw new Error('componentAtIndex called on removed list');
     }
+    /* v8 ignore end */
 
     const platformInfo = childCtx.__listItemPlatformInfo ?? {};
 
diff --git a/packages/react/runtime/src/snapshot/list.ts b/packages/react/runtime/src/snapshot/list.ts
index 35b5e65f25..0c7de36886 100644
--- a/packages/react/runtime/src/snapshot/list.ts
+++ b/packages/react/runtime/src/snapshot/list.ts
@@ -6,6 +6,8 @@ import { hydrate } from '../hydrate.js';
 import { componentAtIndexFactory, enqueueComponentFactory, gRecycleMap, gSignMap } from '../list.js';
 import type { SnapshotInstance } from '../snapshot.js';
 
+const destroyLifetimeHandlerMap = new Map<number, () => void>();
+
 export function snapshotCreateList(
   pageId: number,
   _ctx: SnapshotInstance,
@@ -24,9 +26,12 @@ export function snapshotCreateList(
   const listID = __GetElementUniqueID(list);
 
   if (typeof lynx !== 'undefined' && typeof lynx.getNative === 'function') {
-    lynx.getNative()?.addEventListener('__DestroyLifetime', () => {
+    const cb = () => {
       __UpdateListCallbacks(list, null, null, null);
-    });
+      destroyLifetimeHandlerMap.delete(listID);
+    };
+    lynx.getNative()?.addEventListener('__DestroyLifetime', cb);
+    destroyLifetimeHandlerMap.set(listID, cb);
   }
 
   gSignMap[listID] = signMap;
@@ -38,6 +43,17 @@ export function snapshotDestroyList(si: SnapshotInstance): void {
   const [, elementIndex] = si.__snapshot_def.slot[0]!;
   const list = si.__elements![elementIndex]!;
   const listID = __GetElementUniqueID(list);
+
+  __UpdateListCallbacks(list, () => -1, () => {}, () => {});
+
+  if (typeof lynx !== 'undefined' && typeof lynx.getNative === 'function') {
+    const cb = destroyLifetimeHandlerMap.get(listID);
+    if (cb) {
+      lynx.getNative()?.removeEventListener('__DestroyLifetime', cb);
+      destroyLifetimeHandlerMap.delete(listID);
+    }
+  }
+
   delete gSignMap[listID];
   delete gRecycleMap[listID];
 }
diff --git a/packages/react/testing-library/src/__tests__/list.test.jsx b/packages/react/testing-library/src/__tests__/list.test.jsx
index 759b1e7c66..1bdfef64f8 100644
--- a/packages/react/testing-library/src/__tests__/list.test.jsx
+++ b/packages/react/testing-library/src/__tests__/list.test.jsx
@@ -529,10 +529,6 @@ describe('list', () => {
     act(() => {
       setHide(true);
     });
-
-    expect(() => {
-      elementTree.leaveListItem(list, uid0);
-    }).toThrowErrorMatchingInlineSnapshot(`[Error: enqueueComponent called on removed list]`);
   });
 });