diff --git a/.changeset/eager-bats-refuse.md b/.changeset/eager-bats-refuse.md
new file mode 100644
index 0000000000..d08b38596d
--- /dev/null
+++ b/.changeset/eager-bats-refuse.md
@@ -0,0 +1,21 @@
+---
+"@lynx-js/react-webpack-plugin": patch
+---
+
+Shake `useImperativeHandle` on the main-thread by default.
+
+```js
+import { forwardRef, useImperativeHandle } from '@lynx-js/react';
+
+export default forwardRef(function App(_, ref) {
+  useImperativeHandle(ref, () => {
+    // This should be considered as background only
+    return {
+      name() {
+        // This should be considered as background only
+        console.info('This should not exist in main-thread');
+      },
+    };
+  });
+});
+```
diff --git a/packages/webpack/react-webpack-plugin/src/loaders/options.ts b/packages/webpack/react-webpack-plugin/src/loaders/options.ts
index 1f29721470..1d1b08dd32 100644
--- a/packages/webpack/react-webpack-plugin/src/loaders/options.ts
+++ b/packages/webpack/react-webpack-plugin/src/loaders/options.ts
@@ -244,6 +244,7 @@ export function getMainThreadTransformOptions(
         'useLayoutEffect',
         '__runInJS',
         'useLynxGlobalEventListener',
+        'useImperativeHandle',
         ...(shake?.removeCallParams ?? []),
       ],
     },
diff --git a/packages/webpack/react-webpack-plugin/test/cases/main-thread/use-imperative-handle/index.js b/packages/webpack/react-webpack-plugin/test/cases/main-thread/use-imperative-handle/index.js
new file mode 100644
index 0000000000..b456141e6c
--- /dev/null
+++ b/packages/webpack/react-webpack-plugin/test/cases/main-thread/use-imperative-handle/index.js
@@ -0,0 +1,34 @@
+/// <reference types="vitest/globals" />
+
+import fs from 'node:fs/promises';
+
+import './react.js';
+import './lynx-js-react.js';
+
+it('should have useEffect func in background thread script', async () => {
+  if (__LEPUS__) {
+    return;
+  }
+  const expected = eval(
+    `['This', 'should', 'not', 'exist', 'in', 'main-thread'].join(' ', )`,
+  );
+  const content = await fs.readFile(__filename, 'utf-8');
+
+  expect(content).toContain(expected);
+});
+
+it('should not have useEffect func in main thread script', async () => {
+  if (__JS__) {
+    return;
+  }
+  const expected = eval(
+    `['This', 'should', 'not', 'exist', 'in', 'main-thread'].join(' ', )`,
+  );
+
+  const content = await fs.readFile(
+    __filename,
+    'utf-8',
+  );
+
+  expect(content).not.toContain(expected);
+});
diff --git a/packages/webpack/react-webpack-plugin/test/cases/main-thread/use-imperative-handle/lynx-js-react.js b/packages/webpack/react-webpack-plugin/test/cases/main-thread/use-imperative-handle/lynx-js-react.js
new file mode 100644
index 0000000000..1fad8b3531
--- /dev/null
+++ b/packages/webpack/react-webpack-plugin/test/cases/main-thread/use-imperative-handle/lynx-js-react.js
@@ -0,0 +1,30 @@
+import React, { forwardRef, useImperativeHandle } from '@lynx-js/react';
+import { useEffect } from '@lynx-js/react';
+import { useEffect as useMyEffect } from '@lynx-js/react';
+
+export default forwardRef(function App(_, ref) {
+  function bar() {
+    console.info('This should not exist in main-thread');
+  }
+  useImperativeHandle(ref, () => {
+    console.info('This should not exist in main-thread');
+    return {
+      name() {
+        console.info('This should not exist in main-thread');
+      },
+      bar,
+      baz: 'This should not exist in main-thread',
+    };
+  });
+  useEffect(() => {
+    console.info('This should not exist in main-thread');
+  }, []);
+
+  useMyEffect(() => {
+    // TODO: import alias is not removed
+  });
+
+  React.useEffect(() => {
+    // TODO: default import is not removed
+  });
+});
diff --git a/packages/webpack/react-webpack-plugin/test/cases/main-thread/use-imperative-handle/react.js b/packages/webpack/react-webpack-plugin/test/cases/main-thread/use-imperative-handle/react.js
new file mode 100644
index 0000000000..f2709b6c9a
--- /dev/null
+++ b/packages/webpack/react-webpack-plugin/test/cases/main-thread/use-imperative-handle/react.js
@@ -0,0 +1,30 @@
+import React, { forwardRef, useImperativeHandle } from 'react';
+import { useEffect } from 'react';
+import { useEffect as useMyEffect } from 'react';
+
+export default forwardRef(function App(_, ref) {
+  function bar() {
+    console.info('This should not exist in main-thread');
+  }
+  useImperativeHandle(ref, () => {
+    console.info('This should not exist in main-thread');
+    return {
+      name() {
+        console.info('This should not exist in main-thread');
+      },
+      bar,
+      baz: 'This should not exist in main-thread',
+    };
+  });
+  useEffect(() => {
+    console.info('This should not exist in main-thread');
+  }, []);
+
+  useMyEffect(() => {
+    // TODO: import alias is not removed
+  });
+
+  React.useEffect(() => {
+    // TODO: default import is not removed
+  });
+});
diff --git a/packages/webpack/react-webpack-plugin/test/cases/main-thread/use-imperative-handle/rspack.config.js b/packages/webpack/react-webpack-plugin/test/cases/main-thread/use-imperative-handle/rspack.config.js
new file mode 100644
index 0000000000..d75e332f3c
--- /dev/null
+++ b/packages/webpack/react-webpack-plugin/test/cases/main-thread/use-imperative-handle/rspack.config.js
@@ -0,0 +1,16 @@
+import { createConfig } from '../../../create-react-config.js';
+
+const defaultConfig = createConfig();
+
+/** @type {import('@rspack/core').Configuration} */
+export default {
+  context: __dirname,
+  ...defaultConfig,
+  resolve: {
+    ...defaultConfig.resolve,
+    alias: {
+      'react': '@lynx-js/react',
+      '@lynx-js/react-runtime': '@lynx-js/react',
+    },
+  },
+};
diff --git a/packages/webpack/react-webpack-plugin/test/cases/main-thread/use-imperative-handle/test.config.cjs b/packages/webpack/react-webpack-plugin/test/cases/main-thread/use-imperative-handle/test.config.cjs
new file mode 100644
index 0000000000..2fa53abe09
--- /dev/null
+++ b/packages/webpack/react-webpack-plugin/test/cases/main-thread/use-imperative-handle/test.config.cjs
@@ -0,0 +1,7 @@
+/** @type {import("@lynx-js/test-tools").TConfigCaseConfig} */
+module.exports = {
+  bundlePath: [
+    'main:main-thread.js',
+    'main:background.js',
+  ],
+};