diff --git a/lldb/source/Target/Process.cpp b/lldb/source/Target/Process.cpp
index fdc56e1c310eb..033638f680934 100644
--- a/lldb/source/Target/Process.cpp
+++ b/lldb/source/Target/Process.cpp
@@ -38,6 +38,7 @@
 #include "lldb/Interpreter/CommandInterpreter.h"
 #include "lldb/Interpreter/OptionArgParser.h"
 #include "lldb/Interpreter/OptionValueProperties.h"
+#include "lldb/Interpreter/OptionValueUInt64.h"
 #include "lldb/Symbol/Function.h"
 #include "lldb/Symbol/Symbol.h"
 #include "lldb/Target/ABI.h"
@@ -173,6 +174,13 @@ ProcessProperties::ProcessProperties(lldb_private::Process *process)
     // Global process properties, set them up one time
     m_collection_sp = std::make_shared<ProcessOptionValueProperties>("process");
     m_collection_sp->Initialize(g_process_properties_def);
+    // MemoryCache divides by the cache line size and holds it in a uint32_t, so
+    // reject a value it could not use.
+    OptionValueUInt64 *line_size =
+        m_collection_sp->GetPropertyAtIndexAsOptionValueUInt64(
+            ePropertyMemCacheLineSize);
+    line_size->SetMinimumValue(1);
+    line_size->SetMaximumValue(UINT32_MAX);
     m_collection_sp->AppendProperty(
         "thread", "Settings specific to threads.", true,
         Thread::GetGlobalProperties().GetValueProperties());
diff --git a/lldb/unittests/Target/MemoryTest.cpp b/lldb/unittests/Target/MemoryTest.cpp
index 73f17ca4ce122..97402c4cb6e03 100644
--- a/lldb/unittests/Target/MemoryTest.cpp
+++ b/lldb/unittests/Target/MemoryTest.cpp
@@ -445,6 +445,45 @@ TEST_F(MemoryTest, TestReadStopsAtAnInvalidRange) {
   EXPECT_TRUE(inside_error.Fail());
 }
 
+TEST_F(MemoryTest, TestUnusableCacheLineSize) {
+  ArchSpec arch("arm64-apple-macosx");
+
+  Platform::SetHostPlatform(PlatformRemoteMacOSX::CreateInstance(true, &arch));
+
+  DebuggerSP debugger_sp = Debugger::CreateInstance();
+  ASSERT_TRUE(debugger_sp);
+
+  // A Process copies the global properties when it is constructed, so the
+  // setting must be in place before CreateProcess, and put back afterwards.
+  struct SettingGuard {
+    ~SettingGuard() {
+      Process::GetGlobalProperties().SetPropertyValue(
+          nullptr, eVarSetOperationClear, "memory-cache-line-size", "");
+    }
+  } restore_setting;
+
+  auto set_line_size = [](const char *setting) {
+    return Process::GetGlobalProperties().SetPropertyValue(
+        nullptr, eVarSetOperationAssign, "memory-cache-line-size", setting);
+  };
+
+  // A usable setting must take effect, or the checks below prove nothing.
+  ASSERT_TRUE(set_line_size("256").Success());
+  TargetSP target_sp = CreateTarget(debugger_sp, arch);
+  DummyProcess *process =
+      static_cast<DummyProcess *>(CreateProcess(target_sp).get());
+  EXPECT_EQ(process->GetMemoryCacheLineSize(), 256u);
+
+  for (const char *setting : {"0", "4294967296"}) {
+    SCOPED_TRACE(setting);
+    EXPECT_TRUE(set_line_size(setting).Fail());
+    // Refused, so the last usable value is still in effect.
+    EXPECT_EQ(process->GetMemoryCacheLineSize(), 256u);
+    TargetSP later_target_sp = CreateTarget(debugger_sp, arch);
+    EXPECT_EQ(CreateProcess(later_target_sp)->GetMemoryCacheLineSize(), 256u);
+  }
+}
+
 TEST_F(MemoryTest, TestReadInteger) {
   ArchSpec arch("x86_64-apple-macosx-");